Protein Alignment tw and Pomt2

DIOPT Version :10

• Sequence 1: NP_569858.1
• Gene: tw / 31024
• FlyBaseID: FBgn0086368
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: XP_011242390.2
• Gene: Pomt2 / 217734
• MGIID: 2444430
• Length: 837
• Species: Mus musculus
• Alignment Length: 802
• Identity: 387/802 - (48%)
• Similarity: 507/802 - (63%)
• Gaps: 98/802 - (12%)

  Fly    12 PRRGSVKDVAQNA------PRTAPTSSKEANWN--------WWLLLATVFLVTFATRFYKVTEPD 62
            ||||.....|..|      |:.|....|...|:        ||..||.|.|::|||||:::.:|.
Mouse    86 PRRGRCVPQAARAVSRDVVPQAAARKLKRPAWSSRRFQAAGWWATLAVVTLLSFATRFHRLDQPA 150

  Fly    63 HICWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPGDKYNETRYQGMR 127
            ||||||||||||||:|||||||||||||||||||||:|||:||:|||.|:||||:|....|.|||
Mouse   151 HICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDRYEHHSYMGMR 215

  Fly   128 YFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPILLFFMMASVWGM 192
            .||..||:.::|..:.||.||::|..||||.||.|.||.|.|||:|||||||||:||:||::..|
Mouse   216 GFCAFLGSWLIPFAYLTVLDLSKSFPAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSM 280

  Fly   193 VKVSKSTASGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFVVLLVGLHTATELWLILGDLGQPIL 257
            ||.  ::.:...:...||.||.|||..|:..:.|||||||:::.|||:|.::||.:.|||...::
Mouse   281 VKY--NSCANRPFSAPWWFWLSLTGISLAGALGVKFVGLFIIVQVGLNTISDLWHLFGDLSLSLV 343

  Fly   258 ETVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSLYNASMPRDVA 322
            ...|.|..|.:.|||.|::||:..|.:|:.|||:||.||||:|||||:||.||||:|||:|..:|
Mouse   344 TVGKHLTARILCLIVLPLVLYVTIFAVHVMVLNKSGPGDGFFSSAFQARLSGNSLHNASIPEHLA 408

  Fly   323 YGSLVTIKNHKTGGGYLHSHHHLYPKGSGARQQQVTTYTHKDENNKWLIRPHN---KPGPPKGKV 384
            |||::|:||.:...||||||.||||:|.||||||||||.|||.||.|:|:.:|   .|..|...|
Mouse   409 YGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKYNANTDPLDPSFPV 473

  Fly   385 QILRHGDLVRLTHMATRRNLHSHNEPAPMTKKHLQVTGYGELGLGDANDVWRVLIVGGKVNETVH 449
            :.:||||::||.|..|.||||||...||:|:||.||||||..|.||:||.||:.:|..|....:.
Mouse   474 EFVRHGDIIRLEHKETTRNLHSHYHEAPLTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIK 538

  Fly   450 TVTSRLKFIHLLQNCALTSSGKQLPKWGFEQQEVSCNPNVRD-KNSQWNVEDNEHKLMPSVSFSV 513
            .:.||::.|||:..|.|.||||.|||||:||.||:|.|.::: .||.||:|::.:..:|::|..|
Mouse   539 VLRSRIRLIHLVTGCVLGSSGKILPKWGWEQLEVTCTPYLKETTNSIWNIEEHINPKLPNISLDV 603

  Fly   514 YAPGFFARFLESHAVMLQGNAGLKPKEGEVTSRPWQWPINYRGQFFSGSS---YRIYLLGNPLIW 575
            ..|.|....||||.||::||.|||||:.|.||:||.|||||:|..|||::   :|:||||||::|
Mouse   604 LQPSFPEILLESHMVMIRGNNGLKPKDNEFTSKPWHWPINYQGLRFSGANDTDFRVYLLGNPVVW 668

  Fly   576 WSNLVFLALFVTVFLCNAVVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAK 640
            |.|||.:.|::......||..||       ..|..|::.....|.
Mouse   669 WLNLVSIVLYLLSGSTIAVAMQR-------GIQLPAELQGLTKVL-------------------- 706

  Fly   641 EIVPKAVPSGSPEAPNPAQSLRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLT---- 701
                                ||....|.|||||||.||:.|||:|||||||||::|:|:||
Mouse   707 --------------------LRGGGQLLLGWMLHYFPFFLMGRILYFHHYFPAMLFSSMLTGSPG 751

  Fly   702 -------------GVMYNYILRV---------LPKWIHHV-ILGLVLSILVYSFAAFSPLAYGMS 743
                         |::::.:||:         |.:.||.| ||.|:|: ..|||..|.||||||.
Mouse   752 AVLIGWYMSLLSIGILWDTLLRLCAWGLAPSPLGRRIHAVGILSLLLT-TAYSFYLFHPLAYGMV 815

  Fly   744 GPLANEPNSTMYNLKWLSTWEF 765
            ||||.||.|.|..|:||.:|:|
Mouse   816 GPLAQEPESPMAGLRWLESWDF 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_569858.1	PMT	44..290	CDD:396786	137/245 (56%)
		beta-trefoil_MIR_POMT2	321..503	CDD:467753	100/185 (54%)
		PMT_4TMC	520..761	CDD:465056	106/270 (39%)
Pomt2	XP_011242390.2	PMT	132..376	CDD:396786	137/245 (56%)
		beta-trefoil_MIR_POMT2	407..593	CDD:467753	100/185 (54%)
		PMT_4TMC	612..833	CDD:465056	106/268 (40%)