DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tw and R12E2.13

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_491320.1	Gene:	R12E2.13 / 172010	WormBaseID:	WBGene00020038	Length:	206	Species:	Caenorhabditis elegans

Alignment Length:	166	Identity:	53/166 - (31%)
Similarity:	81/166 - (48%)	Gaps:	11/166 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 GGYLHSHHHLYPKGSGARQQQVTTYTHKDE-NNKWLIRPHNKPGPPKGKVQILRHGDLVRLTHMA 399
            |..||||...|  |||:.||.||...:.|: |:.|.|.|.......:|  ..::.||.:||.|:.
Worm    40 GSRLHSHDVKY--GSGSGQQSVTAVKNSDDINSHWQIFPALNAKCNRG--DAIKCGDKIRLKHLT 100

  Fly   400 TRRNLHSHNEPAPMTKKHLQVTGYGELGLGDANDVWRVLIVGGKVNETVHTVTSRLKFIHLLQNC 464
            |...||||:..||::|:|.:|:.:|.....|..|.|.|:..|.:..|     :.:.|..|.:...
Worm   101 TGTFLHSHHFTAPLSKQHQEVSAFGSEAESDTGDDWTVICNGDEWLE-----SEQFKLRHAVTGS 160

  Fly   465 ALTSSGKQLPKWGFEQQEVSCNPNVRDKNSQWNVED 500
            .|:.||:|..:....|:||....::.. .|.|.|.:
Worm   161 YLSLSGQQFGRPIHGQREVVGTDSITG-GSAWKVAE 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	53/166 (32%)
		PMT	44..290	CDD:280519
		MIR	318..374	CDD:197746	17/38 (45%)
		MIR	385..440	CDD:197746	20/54 (37%)
		MIR	446..501	CDD:197746	13/55 (24%)
		PMT_4TMC	518..763	CDD:292810
R12E2.13	NP_491320.1	MIR	23..77	CDD:197746	17/38 (45%)
		MIR	34..180	CDD:280906	49/148 (33%)
		MIR	85..141	CDD:197746	21/57 (37%)
		MIR	143..195	CDD:197746	13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1660
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2235
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.790