Protein Alignment fz3 and Fzd10

DIOPT Version :9

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_780493.1
• Gene: Fzd10 / 93897
• MGIID: 2136761
• Length: 582
• Species: Mus musculus
• Alignment Length: 542
• Identity: 158/542 - (29%)
• Similarity: 248/542 - (45%)
• Gaps: 93/542 - (17%)

  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELME---- 198
            |:.:..||:|.||....||.|||...|:||..|..|:.||:::||..|.:|   :|  :||
Mouse    68 QLHEFAPLVEYGCHSHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKC---SP--IMEQFKF 127

  Fly   199 LWPSFLNCDGLP-QPEKHELCMQIPQEVAVPGGSPSGPPTTGS------------PGVEDHPQTY 250
            .||..|:|..|| :.:.:.|||:.|       .:.|..|:.||            ...::||
Mouse   128 RWPDSLDCSKLPNKNDPNYLCMEAP-------NNGSDEPSRGSGMFPPLFRPQRPHSAQEHP--- 182

  Fly   251 RFWKSGASPTSDLAGVLCPQNFSGSPFNPEECVPQCQR--DAFHTSSQKKTSETLILGLSAVCFV 313
              .|.|.   ...||...|..|.... ..|.|.|.|..  |.:.:...|:.:...:...|.:||.
Mouse   183 --LKDGG---PGRAGCDNPGKFHHVE-KSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFF 241

  Fly   314 LTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE------LQWRLM 372
            .:.|.::||..:|:||.|||||::||.:||.::||.|:.|:....::...|.:      :|..|.
Mouse   242 SSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLE 306

  Fly   373 RPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLA 437
            ..||.|.      ::...|..:.::.||::..|.::|::.|||..||:|..|..||:.||..|..
Mouse   307 STGCTLV------FLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAV 365

  Fly   438 PPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQP 494
            ..|..|::.:|...||||:||.        .|||.:|....|::|..|.|....:|..:::.::.
Mouse   366 KTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKT 430

  Fly   495 TLAH-HRFGQIRKRFVLFSLLYFAPTTAGVVAALCER----YADSVPS---C------STPDDCL 545
            ...: .:..::..|..:|||||..|.|..:.....||    |...:.:   |      .|| |||
Mouse   431 GGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKMNNQTKTP-DCL 494

  Fly   546 SPTPLSAWPA-LVRIFFQLVGGTLTGLWVWSRKTCESYRN-----------RLGASGTPTSSLMN 598
            ..|.:.|... :|::...||.|..:|:|||:.||.:|:::           |..||...::.:.
Mouse   495 MTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGLKRKSRRKPASVVTSAGIY- 558

  Fly   599 QSKAAGALPKKHLYTSGKSMLP 620
              |.|....|.||   ||..||
Mouse   559 --KKAQHPQKPHL---GKYELP 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	35/90 (39%)
		Frizzled	291..584	CDD:279827	94/321 (29%)
Fzd10	NP_780493.1	CRD_FZ	31..157	CDD:295308	35/100 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..189		8/43 (19%)
		Frizzled	219..536	CDD:279827	94/323 (29%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	527..532		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..582		8/18 (44%)
		PDZ-binding	580..582

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850