DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and Sfrp1

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001263641.2	Gene:	Sfrp1 / 84402	RGDID:	621074	Length:	314	Species:	Rattus norvegicus

Alignment Length:	253	Identity:	55/253 - (21%)
Similarity:	89/253 - (35%)	Gaps:	70/253 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 KGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL- 199
            |.|.:..|||:...|....:..|||...|:|   :.||:..|:.|||.||..|     ..:|:.
  Rat    91 KQQASSWVPLLNKNCHMGTQVFLCSLFAPVC---LDRPIYPCRWLCEAVRDSC-----EPVMQFF 147

  Fly   200 ---WPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPTS 261
               ||..|.||..|:   .::|:.:....|.....|.|  ||..|..:                :
  Rat   148 GFYWPEMLKCDKFPE---GDVCIAMTPPNATEASKPQG--TTVCPPCD----------------N 191

  Fly   262 DLAGVLCPQNFSGSPFNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEP 326
            :|......::...|.|.....:.:.:::........|..:.|.||                   |
  Rat   192 ELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLG-------------------P 237

  Fly   327 TRFGYPERPVLFL-----CLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCLLT 379
            .:....:|.||||     |.|:.|.::             .|:..:..|.::...|||
  Rat   238 IKKKELKRLVLFLKNGADCPCHQLDNL-------------SHNFLIMGRKVKSQYLLT 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	27/89 (30%)
		Frizzled	291..584	CDD:279827	18/94 (19%)
Sfrp1	NP_001263641.2	CRD_SFRP1	52..175	CDD:143552	28/94 (30%)
Sfrp1	NP_001263641.2	NTR_Sfrp1_like	183..306	CDD:239635	24/148 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334852
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740