DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and FZD9

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_003499.1	Gene:	FZD9 / 8326	HGNCID:	4047	Length:	591	Species:	Homo sapiens

Alignment Length:	519	Identity:	161/519 - (31%)
Similarity:	241/519 - (46%)	Gaps:	94/519 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL--- 199
            ::|:..||::.||....||.|||...|:||..|..|:.||:.:||..|..|   ||  :||.
Human    72 ELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRC---AP--IMEQFNF 131

  Fly   200 -WPSFLNCDGLP-QPEKHELCMQIPQEVAVPGGSPSGP--PTTGSPGVEDHPQTYRFWKSGASPT 260
             ||..|:|..|| :.:.|.|||:.|:      .:.:||  |..|...:...|:.       |.|.
Human   132 GWPDSLDCARLPTRNDPHALCMEAPE------NATAGPAEPHKGLGMLPVAPRP-------ARPP 183

  Fly   261 SDL---AGVLCPQNFSGSPFNPEE---------CVPQCQR--DAFHTSSQKKTSETLILGLSAVC 311
            .||   ||      .||:..|||:         |.|:|..  :.|.:...|..:...:...||:|
Human   184 GDLGPGAG------GSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALC 242

  Fly   312 FVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE------LQWR 370
            |..|.|.::||..||.||.|||||::||.:|||::|:.:|.|.|...|:...|.|      :|..
Human   243 FFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEG 307

  Fly   371 LMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPP 435
            |...||.|.      ::...|..:.::.||::..|.::|::.|||..||:|.....||:.||..|
Human   308 LENTGCTLV------FLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLP 366

  Fly   436 LAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQL 492
            ....|..|.|.||...||||:||.        .|||.:|....|:||..|.|....:|..:::.:
Human   367 ALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIM 431

  Fly   493 QPTLAH-HRFGQIRKRFVLFSLLYFAPTTAGVVAALCERY--------ADSVPSCSTPD-----D 543
            :....: .:..::..:..:||:||..|.|..:|..:.||.        |...|..:...     |
Human   432 KTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRD 496

  Fly   544 CLSP---TPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGASGTPTSSLMNQSKAAG 604
            |..|   .|..| ..:::||..||.|..:|:||||.||.::::           ||..:..|||
Human   497 CSLPGGSVPTVA-VFMLKIFMSLVVGITSGVWVWSSKTFQTWQ-----------SLCYRKIAAG 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	36/90 (40%)
		Frizzled	291..584	CDD:279827	101/323 (31%)
FZD9	NP_003499.1	TM helix 1	230..255	CDD:320164	8/24 (33%)
		TM helix 2	264..285	CDD:320164	10/20 (50%)
		TM helix 3	314..340	CDD:320164	5/31 (16%)
		TM helix 4	357..373	CDD:320164	6/15 (40%)
		TM helix 5	395..425	CDD:320164	9/29 (31%)
		TM helix 6	444..471	CDD:320164	8/26 (31%)
		TM helix 7	503..528	CDD:320164	8/25 (32%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	532..537		2/4 (50%)
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	554..591
		CRD_FZ	35..161	CDD:321937	36/99 (36%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	58..172		40/110 (36%)
		7tmF_FZD9	221..542	CDD:320164	103/338 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850