DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and FZD9

DIOPT Version :10

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_003499.1 Gene:FZD9 / 8326 HGNCID:4047 Length:591 Species:Homo sapiens


Alignment Length:519 Identity:161/519 - (31%)
Similarity:241/519 - (46%) Gaps:94/519 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL--- 199
            ::|:..||::.||....||.|||...|:||..|..|:.||:.:||..|..|   ||  :||.   
Human    72 ELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRC---AP--IMEQFNF 131

  Fly   200 -WPSFLNCDGLP-QPEKHELCMQIPQEVAVPGGSPSGP--PTTGSPGVEDHPQTYRFWKSGASPT 260
             ||..|:|..|| :.:.|.|||:.|:      .:.:||  |..|...:...|:.       |.|.
Human   132 GWPDSLDCARLPTRNDPHALCMEAPE------NATAGPAEPHKGLGMLPVAPRP-------ARPP 183

  Fly   261 SDL---AGVLCPQNFSGSPFNPEE---------CVPQCQR--DAFHTSSQKKTSETLILGLSAVC 311
            .||   ||      .||:..|||:         |.|:|..  :.|.:...|..:...:...||:|
Human   184 GDLGPGAG------GSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALC 242

  Fly   312 FVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE------LQWR 370
            |..|.|.::||..||.||.|||||::||.:|||::|:.:|.|.|...|:...|.|      :|..
Human   243 FFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEG 307

  Fly   371 LMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPP 435
            |...||.|.      ::...|..:.::.||::..|.::|::.|||..||:|.....||:.||..|
Human   308 LENTGCTLV------FLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLP 366

  Fly   436 LAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQL 492
            ....|..|.|.||...||||:||.        .|||.:|....|:||..|.|....:|..:::.:
Human   367 ALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIM 431

  Fly   493 QPTLAH-HRFGQIRKRFVLFSLLYFAPTTAGVVAALCERY--------ADSVPSCSTPD-----D 543
            :....: .:..::..:..:||:||..|.|..:|..:.||.        |...|..:...     |
Human   432 KTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRD 496

  Fly   544 CLSP---TPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGASGTPTSSLMNQSKAAG 604
            |..|   .|..| ..:::||..||.|..:|:||||.||.::::           ||..:..|||
Human   497 CSLPGGSVPTVA-VFMLKIFMSLVVGITSGVWVWSSKTFQTWQ-----------SLCYRKIAAG 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM_1 22..83 CDD:425453
CRD_FZ <138..224 CDD:470581 36/90 (40%)
7tmF_FZD3_insect 290..587 CDD:320159 101/327 (31%)
TM helix 1 299..324 CDD:320159 8/24 (33%)
TM helix 2 333..354 CDD:320159 10/20 (50%)
TM helix 3 383..409 CDD:320159 4/25 (16%)
TM helix 4 426..442 CDD:320159 6/15 (40%)
TM helix 5 469..493 CDD:320159 6/23 (26%)
TM helix 6 513..540 CDD:320159 9/34 (26%)
TM helix 7 548..573 CDD:320159 8/24 (33%)
FZD9NP_003499.1 CRD_FZ 35..161 CDD:470581 36/99 (36%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 58..172 40/110 (36%)
7tmF_FZD9 221..542 CDD:320164 103/338 (30%)
TM helix 1 230..255 CDD:320164 8/24 (33%)
TM helix 2 264..285 CDD:320164 10/20 (50%)
TM helix 3 314..340 CDD:320164 5/31 (16%)
TM helix 4 357..373 CDD:320164 6/15 (40%)
TM helix 5 395..425 CDD:320164 9/29 (31%)
TM helix 6 444..471 CDD:320164 8/26 (31%)
TM helix 7 503..528 CDD:320164 8/25 (32%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 532..537 2/4 (50%)
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 554..591
Blue background indicates that the domain is not in the aligned region.

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