Protein Alignment fz3 and FZD6

DIOPT Version :9

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001158087.1
• Gene: FZD6 / 8323
• HGNCID: 4044
• Length: 706
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 136/559 - (24%)
• Similarity: 219/559 - (39%)
• Gaps: 121/559 - (21%)

  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL--- 199
            ::...:||....||......||.:..|.|...: ..|..|:.|||.|..:|     .:|::.
Human    57 EMEHFLPLANLECSPNIETFLCKAFVPTCIEQI-HVVPPCRKLCEKVYSDC-----KKLIDTFGI 115

  Fly   200 -WPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVED-HPQTYRFWKSGASPTSD 262
             ||..|.||.|      :.|.:.             .|.|..|..|. .||     |.......|
Human   116 RWPEELECDRL------QYCDET-------------VPVTFDPHTEFLGPQ-----KKTEQVQRD 156

  Fly   263 LAGVLCPQNFSGSP------FNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVT 321
            : |..||::...|.      ...::|.|.|. :.:..|.:.:.:::.|..:|..|...|||..:|
Human   157 I-GFWCPRHLKTSGGQGYKFLGIDQCAPPCP-NMYFKSDELEFAKSFIGTVSIFCLCATLFTFLT 219

  Fly   322 FWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCL--LTPPCLA 384
            |..:..||.|||||:::..:||::.|:.|....:..:....:..:.:..|.....|  ....|..
Human   220 FLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTV 284

  Fly   385 SYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVR 449
            .::...:.::....||:|..:.::|::.:|||.||:|:::..||.:||..|....:..|.:.||.
Human   285 LFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVE 349

  Fly   450 PSELTGMCY--------APGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHRFGQIR- 505
            ...::|:|:        :..||.||..:.:.:||...|....||..::|.:|    |....|.:
Human   350 GDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQ----HDGRNQEKL 410

  Fly   506 KRFVL----FSLLYFAP--TTAGV---------------VAALCERYADSVPSCSTPDDCLSPTP 549
            |:|::    ||.||..|  |..|.               |:..|.:|  .:|       |.....
Human   411 KKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQY--HIP-------CPYQAK 466

  Fly   550 LSAWPAL----VRIFFQLVGGTLTGLWVWSRKTCESY-----RNRLGASGTPTSS---------- 595
            ..|.|.|    ::....|:.|.....||.|:|||..:     |||   ...|.|.
Human   467 AKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNR---KRDPISESRRVLQESCE 528

  Fly   596 --LMNQSKAAGALPKKH-------LYTSGKSMLPTGGIT 625
              |.:.||...  .|||       |....|||..:.|.|
Human   529 FFLKHNSKVKH--KKKHYKPSSHKLKVISKSMGTSTGAT 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	23/89 (26%)
		Frizzled	291..584	CDD:279827	81/333 (24%)
FZD6	NP_001158087.1	CRD_FZ6	20..146	CDD:143559	27/113 (24%)
		Frizzled	189..507	CDD:279827	81/330 (25%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	498..503		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	588..706

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820