DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and FZD4

DIOPT Version :10

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_036325.2 Gene:FZD4 / 8322 HGNCID:4042 Length:537 Species:Homo sapiens


Alignment Length:490 Identity:139/490 - (28%)
Similarity:225/490 - (45%) Gaps:81/490 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 DEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELME 198
            |.:.|:....|||:.|||.:.:|.|||...|:||..:..|:..|..:|.:|:..|    .|.|.|
Human    74 DAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRC----EPVLKE 134

  Fly   199 L---WPSFLNCDGL-PQPEKHELCMQIP--QEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGA 257
            .   ||..|||... ||.:.:.:||:.|  :||.:|..:|.      .||.|.|        |..
Human   135 FGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPI------QPGEECH--------SVG 185

  Fly   258 SPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDA-FHTSSQKKTSETLILGLSAVCFVLTLFALVT 321
            :.:.....|....|          ||.:|..|| .::.|.|:.::..:...:::||:.|.|.::|
Human   186 TNSDQYIWVKRSLN----------CVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLT 240

  Fly   322 FWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE-------LQWRLMRPGCLLT 379
            |..:.:||.|||||::||.:|||::|:.|:.|:....:....|.|       :|..|...||.:.
Human   241 FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAII 305

  Fly   380 PPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALL 444
                  ::...:..:.::.||:|..|.::|::..||..||:|..|..||:.||..|....|..|:
Human   306 ------FLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILI 364

  Fly   445 LEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPT-LAHHR 500
            :..|...||||:||.        .|||..|....|::|..|......:|..::..||.. ....:
Human   365 MRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDK 429

  Fly   501 FGQIRKRFVLFSLLYFAPTTAGVVAALCE-------RYADSVPSCSTPDDCLSPTPLSAWPALVR 558
            ..::..:..:||:||..|.|..:.....|       ||       |..|..::       ..:::
Human   430 LERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRY-------SADDSNMA-------VEMLK 480

  Fly   559 IFFQLVGGTLTGLWVWSRKTCESYR---NRLGASG 590
            ||..|:.|..:|:|:||.||..:::   |||..||
Human   481 IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSG 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM_1 22..83 CDD:425453
CRD_FZ <138..224 CDD:470581 32/91 (35%)
7tmF_FZD3_insect 290..587 CDD:320159 88/323 (27%)
TM helix 1 299..324 CDD:320159 6/24 (25%)
TM helix 2 333..354 CDD:320159 10/20 (50%)
TM helix 3 383..409 CDD:320159 4/25 (16%)
TM helix 4 426..442 CDD:320159 6/15 (40%)
TM helix 5 469..493 CDD:320159 4/23 (17%)
TM helix 6 513..540 CDD:320159 7/33 (21%)
TM helix 7 548..573 CDD:320159 5/24 (21%)
FZD4NP_036325.2 CRD_FZ4 42..167 CDD:143557 33/96 (34%)
7tmF_FZD4 209..509 CDD:320166 85/319 (27%)
TM helix 1 218..243 CDD:320166 6/24 (25%)
TM helix 2 252..273 CDD:320166 10/20 (50%)
TM helix 3 303..329 CDD:320166 4/31 (13%)
TM helix 4 346..362 CDD:320166 6/15 (40%)
TM helix 5 384..413 CDD:320166 7/28 (25%)
TM helix 6 433..460 CDD:320166 7/26 (27%)
TM helix 7 470..495 CDD:320166 6/31 (19%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 499..504 2/4 (50%)
PDZ-binding 535..537
Blue background indicates that the domain is not in the aligned region.

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