DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and FZD1

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_003496.1	Gene:	FZD1 / 8321	HGNCID:	4038	Length:	647	Species:	Homo sapiens

Alignment Length:	521	Identity:	136/521 - (26%)
Similarity:	213/521 - (40%)	Gaps:	103/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||...:|.|||...|:||. :.:.:..|:.|||..|..|     ..||
Human   144 EDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTV-LEQALPPCRSLCERARQGC-----EALM 202

  Fly   198 E----LWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKS--- 255
            .    .||..|.|:..|.....|||  :.|..     |..|.||   |.:  .|:   ||.|
Human   203 NKFGFQWPDTLKCEKFPVHGAGELC--VGQNT-----SDKGTPT---PSL--LPE---FWTSNPQ 252

  Fly   256 -----------GASPTSDLAGVLCPQ----------NFSGSPFNPEECVPQCQRD-----AFHTS 294
                       |.:..|:.....||:          :|.|.    ::|...|:..     .:...
Human   253 HGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGE----KDCGAPCEPTKVYGLMYFGP 313

  Fly   295 SQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQ 359
            .:.:.|.|.|...|.:|...|||.::|:..:..||.|||||::||..||...:|.|:...:..::
Human   314 EELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDR 378

  Fly   360 ARMHD--VELQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEK 422
            ...:|  .|...|.:..| .....|...::...:.|:.::.||:|.:|.::|::..||..||:|.
Human   379 VVCNDKFAEDGARTVAQG-TKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEA 442

  Fly   423 RSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTL 479
            .|..||:.||..|....|..|.|.:|....|:|:|:.        .|||..|..|.|.:|..|.|
Human   443 NSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLL 507

  Fly   480 RASRSLLSLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGV--------------- 523
            ....||..::     |:..|      :..::..|..:||:||..|.|..:
Human   508 AGFVSLFRIR-----TIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWER 567

  Fly   524 --VAALCERYADSVPSCSTPDDCLSPTPLSAWP----ALVRIFFQLVGGTLTGLWVWSRKTCESY 582
              ||..|:.||...|............|:|  |    .:::....|:.|..:|.|:||.||..|:
Human   568 SWVAQSCKSYAIPCPHLQAGGGAPPHPPMS--PDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSW 630

  Fly   583 R 583
            |
Human   631 R 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	27/89 (30%)
		Frizzled	291..584	CDD:279827	90/330 (27%)
FZD1	NP_003496.1	CRD_FZ1	112..238	CDD:143574	31/106 (29%)
FZD1	NP_003496.1	Frizzled	310..634	CDD:279827	90/330 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750