DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and SMO

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_005622.1	Gene:	SMO / 6608	HGNCID:	11119	Length:	787	Species:	Homo sapiens

Alignment Length:	562	Identity:	131/562 - (23%)
Similarity:	206/562 - (36%)	Gaps:	112/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SDDEKGQIAKLVPLIESGCSRRARF------LLCSSLFPLCTPDVPRPVAACKLLCETVRGECME 190
            ||.::....|||  :.||.....|.      |||:...|.|..|  |.....:.||:..||.|
Human    96 SDSQEEAHGKLV--LWSGLRNAPRCWAVIQPLLCAVYMPKCEND--RVELPSRTLCQATRGPC-- 154

  Fly   191 NAPPELMELWPSFLNC--DGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFW 253
             |..|....||.||.|  |..|     |.|....|.:..........|...:    |:|:::
Human   155 -AIVERERGWPDFLRCTPDRFP-----EGCTNEVQNIKFNSSGQCEVPLVRT----DNPKSW--- 206

  Fly   254 KSGASPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFA 318
                  ..|:.|                |..|||...| |.::.:...:.|....||..:.|||.
Human   207 ------YEDVEG----------------CGIQCQNPLF-TEAEHQDMHSYIAAFGAVTGLCTLFT 248

  Fly   319 LVTF---WAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDV---ELQWRLMRPGCL 377
            |.||   |....|  ||...:.::..|:.:.|:.:|.:  |.:.||...|   :...||..|...
Human   249 LATFVADWRNSNR--YPAVILFYVNACFFVGSIGWLAQ--FMDGARREIVCRADGTMRLGEPTSN 309

  Fly   378 LTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSS-EALEKRSGLFHVLAWVPPLAPPIA 441
            .|..|:..::...|..:....|:::....::.|.....:: :.|..::..||:|.|..|....:|
Human   310 ETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVA 374

  Fly   442 ALLLEKVRPSELTGMC--------YAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAH 498
            .|.:.:|....::|:|        |..|||..|..::|::|.||.:|...:|.|::......|:.
Human   375 ILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSE 439

  Fly   499 HRFGQIRK---RFVLFSLLYFAPTTAGVVA-----------------------ALCE-RYADSVP 536
            ....:|.:   |..:|..|.|     |.|.                       .||: .....:|
Human   440 KAASKINETMLRLGIFGFLAF-----GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLP 499

  Fly   537 SCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRN---RL-GASGTPTSSLM 597
            :.....||......|.....:.:|.....|.....|||::.|...:|.   || |.|......:.
Human   500 TKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIK 564

  Fly   598 NQSKAAGALPKKH--LYTSGK----SMLPTGGITPLYAGISF 633
            .....|.|..|:|  |...|:    ||.......|: ||::|
Human   565 KSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV-AGLAF 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	29/93 (31%)
		Frizzled	291..584	CDD:279827	73/334 (22%)
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	32/111 (29%)
SMO	NP_005622.1	Frizzled	221..550	CDD:279827	74/338 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820