DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and Fzd4

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_072145.1	Gene:	Fzd4 / 64558	RGDID:	71017	Length:	538	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	139/490 - (28%)
Similarity:	225/490 - (45%)	Gaps:	81/490 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 DEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELME 198
            |.:.|:....|||:.|||.:.:|.|||...|:||..:..|:..|..:|.:|:..|    .|.|.|
  Rat    75 DAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRC----EPVLKE 135

  Fly   199 L---WPSFLNCDGL-PQPEKHELCMQIP--QEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGA 257
            .   ||..|||... ||.:.:.:||:.|  :||.:|..:|.      .||.|.|        |..
  Rat   136 FGFAWPDSLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPI------QPGEECH--------SVG 186

  Fly   258 SPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDA-FHTSSQKKTSETLILGLSAVCFVLTLFALVT 321
            :.:.....|....|          ||.:|..|| .::.|.|:.::..:...:::||:.|.|.::|
  Rat   187 TNSDQYIWVKRSLN----------CVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLT 241

  Fly   322 FWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE-------LQWRLMRPGCLLT 379
            |..:.:||.|||||::||.:|||::|:.|:.|:....:....|.|       :|..|...||.:.
  Rat   242 FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAII 306

  Fly   380 PPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALL 444
                  ::...:..:.::.||:|..|.::|::..||..||:|..|..||:.||..|....|..|:
  Rat   307 ------FLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILI 365

  Fly   445 LEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPT-LAHHR 500
            :..|...||||:||.        .|||..|....|::|..|......:|..::..||.. ....:
  Rat   366 MRLVDADELTGLCYVGNQSLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDK 430

  Fly   501 FGQIRKRFVLFSLLYFAPTTAGVVAALCE-------RYADSVPSCSTPDDCLSPTPLSAWPALVR 558
            ..::..:..:||:||..|.|..:.....|       ||       |..|..::       ..:::
  Rat   431 LERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRY-------SADDSNMA-------VEMLK 481

  Fly   559 IFFQLVGGTLTGLWVWSRKTCESYR---NRLGASG 590
            ||..|:.|..:|:|:||.||..:::   |||..||
  Rat   482 IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSG 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	32/91 (35%)
		Frizzled	291..584	CDD:279827	85/318 (27%)
Fzd4	NP_072145.1	CRD_FZ4	43..168	CDD:143557	33/96 (34%)
		Frizzled	211..510	CDD:279827	85/318 (27%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	500..505		2/4 (50%)
		PDZ-binding	536..538
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820