DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz3 and Fzd1

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_067089.2	Gene:	Fzd1 / 58868	RGDID:	61916	Length:	642	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	137/523 - (26%)
Similarity:	213/523 - (40%)	Gaps:	107/523 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||...:|.|||...|:||. :.:.:..|:.|||..|..|     ..||
  Rat   139 EDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTV-LEQALPPCRSLCERARQGC-----EALM 197

  Fly   198 E----LWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKS--- 255
            .    .||..|.|:..|.....|||  :.|..     |..|.||   |.:  .|:   ||.|
  Rat   198 NKFGFQWPDTLKCEKFPVHGAGELC--VGQNT-----SDKGTPT---PSL--LPE---FWTSNPQ 247

  Fly   256 ------------GASPTSDLAGVLCPQ----------NFSGSPFNPEECVPQCQRD-----AFHT 293
                        ||.|. :.....||:          :|.|.    ::|...|:..     .:..
  Rat   248 HGGGGYRGGYPGGAGPV-ERGKFSCPRALRVPSYLNYHFLGE----KDCGAPCEPTKVYGLMYFG 307

  Fly   294 SSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHN 358
            ..:.:.|.|.|...|.:|...|||.::|:..:..||.|||||::||..||...:|.|:...:..:
  Rat   308 PEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLED 372

  Fly   359 QARMHD--VELQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALE 421
            :...:|  .|...|.:..| .....|...::...:.|:.::.||:|.:|.::|::..||..||:|
  Rat   373 RVVCNDKFAEDGARTVAQG-TKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIE 436

  Fly   422 KRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFT 478
            ..|..||:.||..|....|..|.|.:|....|:|:|:.        .|||..|..|.|.:|..|.
  Rat   437 ANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFL 501

  Fly   479 LRASRSLLSLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGV-------------- 523
            |....||..::     |:..|      :..::..|..:||:||..|.|..:
  Rat   502 LAGFVSLFRIR-----TIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWE 561

  Fly   524 ---VAALCERYADSVPSCS-----TPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCE 580
               ||..|:.||...|...     .|...:||   .....:::....|:.|..:|.|:||.||..
  Rat   562 RSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSP---DFTVFMIKYLMTLIVGITSGFWIWSGKTLN 623

  Fly   581 SYR 583
            |:|
  Rat   624 SWR 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	27/89 (30%)
		Frizzled	291..584	CDD:279827	90/331 (27%)
Fzd1	NP_067089.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..99
		CRD_FZ1	107..233	CDD:143574	31/106 (29%)
		Frizzled	305..629	CDD:279827	90/331 (27%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	620..625		2/4 (50%)
		PDZ-binding	640..642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334856
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750