Protein Alignment fz3 and Fzd2

DIOPT Version :9

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_065256.1
• Gene: Fzd2 / 57265
• MGIID: 1888513
• Length: 570
• Species: Mus musculus
• Alignment Length: 531
• Identity: 134/531 - (25%)
• Similarity: 218/531 - (41%)
• Gaps: 128/531 - (24%)

  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||...||.|||...|:||. :.:.:..|:.:||..|..|     ..||
Mouse    72 EDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQGC-----EALM 130

  Fly   198 E----LWPSFLNCDGLPQPEKHELCM-QIPQEVAVP---------------GGSPSGPPTTGSP- 241
            .    .||..|.|:..|:....::|: |...|...|               ||:|.||...|||
Mouse   131 NKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPP 195

  Fly   242 --GVEDHPQTYRFWKSGASPTSDLAGVLCPQ----------NFSGSPFNPEECVPQCQ-----RD 289
              ...:||                  ..||:          .|.|.    .:|...|:     ..
Mouse   196 RYATLEHP------------------FHCPRVLKVPSYLSYKFLGE----RDCAAPCEPARPDGS 238

  Fly   290 AFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYL--- 351
            .|.:..:.:.:...||..|.:|...|.|.:.|:..:..||.|||||::||..||.:.||.|:
Mouse   239 MFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGF 303

  Fly   352 ---ERIVFHNQARMHDVELQWRLM-----RPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFY 408
               ||:|.:.:..    |..:|.:     :.||.:.      ::...:.|:.::.||:|.:|.::
Mouse   304 VLQERVVCNERFS----EDGYRTVVQGTKKEGCTIL------FMMLYFFSMASSIWWVILSLTWF 358

  Fly   409 LSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVEL 465
            |::..||..||:|..|..||:.||..|....|..|.:.::....|:|:|:.        .|||..
Mouse   359 LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLA 423

  Fly   466 PALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGV- 523
            |..|.|.:|..|.|....||..::     |:..|      :..::..|..:||:||..|.|..:
Mouse   424 PLFVYLFIGTSFLLAGFVSLFRIR-----TIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIA 483

  Fly   524 ----------------VAALCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLW 572
                            |:..|:..|...|:..||.  :|| ..:.:  :::....|:.|..:|.|
Mouse   484 CYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPR--MSP-DFTVY--MIKYLMTLIVGITSGFW 543

  Fly   573 VWSRKTCESYR 583
            :||.||..|:|
Mouse   544 IWSGKTLHSWR 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	26/90 (29%)
		Frizzled	291..584	CDD:279827	89/335 (27%)
Fzd2	NP_065256.1	CRD_FZ2	40..166	CDD:143573	28/99 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..194		7/27 (26%)
		Frizzled	240..557	CDD:279827	89/335 (27%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	548..553		2/4 (50%)
		PDZ-binding	568..570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750