DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and Fzd2

DIOPT Version :10

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_065256.1 Gene:Fzd2 / 57265 MGIID:1888513 Length:570 Species:Mus musculus


Alignment Length:531 Identity:134/531 - (25%)
Similarity:218/531 - (41%) Gaps:128/531 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||...||.|||...|:||. :.:.:..|:.:||..|..|     ..||
Mouse    72 EDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQGC-----EALM 130

  Fly   198 E----LWPSFLNCDGLPQPEKHELCM-QIPQEVAVP---------------GGSPSGPPTTGSP- 241
            .    .||..|.|:..|:....::|: |...|...|               ||:|.||...||| 
Mouse   131 NKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPP 195

  Fly   242 --GVEDHPQTYRFWKSGASPTSDLAGVLCPQ----------NFSGSPFNPEECVPQCQ-----RD 289
              ...:||                  ..||:          .|.|.    .:|...|:     ..
Mouse   196 RYATLEHP------------------FHCPRVLKVPSYLSYKFLGE----RDCAAPCEPARPDGS 238

  Fly   290 AFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYL--- 351
            .|.:..:.:.:...||..|.:|...|.|.:.|:..:..||.|||||::||..||.:.||.|:   
Mouse   239 MFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGF 303

  Fly   352 ---ERIVFHNQARMHDVELQWRLM-----RPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFY 408
               ||:|.:.:..    |..:|.:     :.||.:.      ::...:.|:.::.||:|.:|.::
Mouse   304 VLQERVVCNERFS----EDGYRTVVQGTKKEGCTIL------FMMLYFFSMASSIWWVILSLTWF 358

  Fly   409 LSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVEL 465
            |::..||..||:|..|..||:.||..|....|..|.:.::....|:|:|:.        .|||..
Mouse   359 LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLA 423

  Fly   466 PALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGV- 523
            |..|.|.:|..|.|....||..::     |:..|      :..::..|..:||:||..|.|..: 
Mouse   424 PLFVYLFIGTSFLLAGFVSLFRIR-----TIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIA 483

  Fly   524 ----------------VAALCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLW 572
                            |:..|:..|...|:..||.  :|| ..:.:  :::....|:.|..:|.|
Mouse   484 CYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPR--MSP-DFTVY--MIKYLMTLIVGITSGFW 543

  Fly   573 VWSRKTCESYR 583
            :||.||..|:|
Mouse   544 IWSGKTLHSWR 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM_1 22..83 CDD:425453
CRD_FZ <138..224 CDD:470581 26/90 (29%)
7tmF_FZD3_insect 290..587 CDD:320159 89/336 (26%)
TM helix 1 299..324 CDD:320159 7/24 (29%)
TM helix 2 333..354 CDD:320159 11/26 (42%)
TM helix 3 383..409 CDD:320159 5/25 (20%)
TM helix 4 426..442 CDD:320159 6/15 (40%)
TM helix 5 469..493 CDD:320159 7/23 (30%)
TM helix 6 513..540 CDD:320159 8/43 (19%)
TM helix 7 548..573 CDD:320159 3/24 (13%)
Fzd2NP_065256.1 CRD_FZ2 40..166 CDD:143573 28/99 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..194 7/27 (26%)
7tmF_FZD2 239..568 CDD:320373 89/336 (26%)
TM helix 1 248..273 CDD:320373 7/24 (29%)
TM helix 2 282..303 CDD:320373 10/20 (50%)
TM helix 3 333..359 CDD:320373 5/31 (16%)
TM helix 4 376..392 CDD:320373 6/15 (40%)
TM helix 5 414..443 CDD:320373 9/28 (32%)
TM helix 6 463..490 CDD:320373 7/26 (27%)
TM helix 7 519..544 CDD:320373 5/27 (19%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 548..553 2/4 (50%)
PDZ-binding 568..570
Blue background indicates that the domain is not in the aligned region.

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