DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and sfrp2

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001070852.2	Gene:	sfrp2 / 566878	ZFINID:	ZDB-GENE-061013-293	Length:	294	Species:	Danio rerio

Alignment Length:	193	Identity:	48/193 - (24%)
Similarity:	81/193 - (41%)	Gaps:	38/193 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL--- 199
            |.:...||::..|....:..|||...|:|..|:..|:..|:.|||:|:..|   ||  :|..
Zfish    73 QASSWTPLVQKQCHPDTKKFLCSLFAPVCLDDLDEPIQPCRSLCESVKSGC---AP--VMAAFGF 132

  Fly   200 -WPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPTSDL 263
             ||..|:|...|.  .::||  ||     |.|:.:..|.|     ::.|:.....|......:::
Zfish   133 PWPDMLDCRRFPL--DNDLC--IP-----PAGADALVPVT-----KEVPRVCDACKEKPENDNEI 183

  Fly   264 AGVLCPQNFS-------GSPFNPE-ECVPQCQRDAFHTSSQ-------KKTSETLILGLSAVC 311
            ...||..:|:       .|..|.: :.:|:.:....:.::.       :||...|..||..||
Zfish   184 VDSLCKNDFALKIKVKEISYMNGDTKIIPETKTKMIYKTNGGVTDHDFRKTVLWLKDGLQCVC 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	29/89 (33%)
		Frizzled	291..584	CDD:279827	7/28 (25%)
sfrp2	NP_001070852.2	CRD_SFRP2	34..161	CDD:143555	31/101 (31%)
sfrp2	NP_001070852.2	NTR_Sfrp1_like	167..294	CDD:239635	15/80 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740