DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and fzd3a

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_005160805.1	Gene:	fzd3a / 565921	ZFINID:	ZDB-GENE-990415-225	Length:	686	Species:	Danio rerio

Alignment Length:	505	Identity:	129/505 - (25%)
Similarity:	195/505 - (38%)	Gaps:	136/505 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL----WPSFL 204
            |::...||...|..||:...|:|| :..|....|:.||:..:.:|.     :|||:    ||..:
Zfish    69 PMVNLECSTEIRPFLCALYAPVCT-EYGRVTLPCRRLCQRAKSDCY-----KLMEMFGVSWPDEM 127

  Fly   205 NCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPTSDLAGVLCP 269
            .|...|:.|:     ..|:.:.:   .||...|..||....  :.|.||              ||
Zfish   128 ECSRFPECEE-----SYPRAIDL---LPSSDSTEESPSAVQ--RDYGFW--------------CP 168

  Fly   270 QNFSGSP------FNPEECVPQCQRDAFHTSSQKKTSETLILG------LSAVCFVLTLFALVTF 322
            :.....|      ....:|.|.|....|.       .:.||..      :|.||...|||..:||
Zfish   169 RELKIEPDLGYSFMGVRDCSPPCPNMYFR-------KDELIFARYFIGVISIVCLSATLFTFLTF 226

  Fly   323 WAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCLLTPP------ 381
            ..:..||.|||||::|..:||.:.|      :||.....:.|        |..|....|
Zfish   227 LIDVGRFRYPERPIIFYAVCYMMVS------LVFFLGFLLED--------RVSCNTASPGRFRAS 277

  Fly   382 ----------CLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPL 436
                      |...::|..:.::..:.||:|..:.::|::..||.|||:||::.|||.:||..|.
Zfish   278 TITQGSHNKACTLLFMTLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGVPG 342

  Fly   437 APPIAALLLEKVRPSELTGMCYAPGFVELPAL----------------VLLLLGLYFTLRASRSL 485
            |..|..:.:.|:....::|:|:. |..:|.||                ||||.|: ..|...|..
Zfish   343 ALTITLMAMNKIEGDSMSGVCFV-GLYDLMALRWFLLVPLVLDVIVGVVLLLAGI-AALNRVRME 405

  Fly   486 LSLQQQLQPTLAHHRFGQIRKRFVLFSLLYFAP--TTAGV---------------VAALCERYAD 533
            :.|:::.|..|.     :...|..:||:||..|  |..|.               |...|..|..
Zfish   406 IPLEKENQDKLV-----KFMIRIGVFSVLYLVPLLTVIGCYLYEQSHRSVWETTWVQERCREYHI 465

  Fly   534 SVP----SCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTC 579
            ..|    ..|.||..|         .|::....||.|..:..||.|:|||
Zfish   466 PCPFKVEKTSRPDIAL---------FLIKYLMMLVVGIPSVFWVGSKKTC 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	23/83 (28%)
		Frizzled	291..584	CDD:279827	92/348 (26%)
fzd3a	XP_005160805.1	CRD_FZ3	26..152	CDD:143558	25/96 (26%)
fzd3a	XP_005160805.1	Frizzled	195..513	CDD:279827	92/349 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750