DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and col18a1a

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_021334395.1	Gene:	col18a1a / 564123	ZFINID:	ZDB-GENE-030516-3	Length:	1645	Species:	Danio rerio

Alignment Length:	158	Identity:	37/158 - (23%)
Similarity:	51/158 - (32%)	Gaps:	47/158 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECM----ENAPPELMELWPSFLN 205
            |:.|||.....:..|..|.|.|...  ..:..|:..||.::..|.    |...|         :.
Zfish   249 LLRSGCHHSLEWFFCLLLTPRCGHS--GSLLPCRSSCEVLQDSCWTLLDEGRLP---------VE 302

  Fly   206 CDGLPQPEKHE--LCMQIPQEVAVPGGS----PSGPPTTG---------SPGVEDHPQT------ 249
            |..||: |||:  .|:.:.......|.|    ...||..|         |||....|.:
Zfish   303 CKSLPE-EKHDGYRCLSVSNLKEESGVSLLQLIGDPPPNGVSKVFDQANSPGYVFGPSSNVGQSA 366

  Fly   250 --------YRFWK--SGASPTSDLAGVL 267
                    ||.:.  ....|||...||:
Zfish   367 AAHLPNPFYRDFSLIFNIKPTSSKPGVI 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	21/84 (25%)
		Frizzled	291..584	CDD:279827
col18a1a	XP_021334395.1	CRD_Collagen_XVIII	203..340	CDD:143564	25/102 (25%)
		LamG	327..516	CDD:328935	16/68 (24%)
		Collagen	816..860	CDD:189968
		Collagen	<937..980	CDD:189968
		Collagen	959..1055	CDD:189968
		Endostatin	1471..1639	CDD:310825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810