DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and fzd7

DIOPT Version :10

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_001016741.1 Gene:fzd7 / 549495 XenbaseID:XB-GENE-483731 Length:548 Species:Xenopus tropicalis


Alignment Length:511 Identity:130/511 - (25%)
Similarity:213/511 - (41%) Gaps:85/511 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||...||.|||...|:||. :.:.:..|:.|||..|..|     ..||
 Frog    64 EDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSLCERARQGC-----EALM 122

  Fly   198 E----LWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVED----HPQTYRFWK 254
            .    .||..|.|:..|.....|:|  :.|..:  ..|||||....:|.:.|    ||...|   
 Frog   123 NKFGFQWPERLRCENFPIHGAGEIC--VGQNTS--DNSPSGPTARPTPYLPDSITFHPHLNR--- 180

  Fly   255 SGASPTSDLAGVLCPQNFSGSPF------NPEECVPQCQRDAFHTSSQKKTSET----LILGLSA 309
                      ...||:.....|:      ..::|...|:....:.....|..|.    |.:|:.|
 Frog   181 ----------DFTCPRQLKVPPYLGYRFLGEKDCGAPCEPGKANGLMYFKEEEVRFARLWVGIWA 235

  Fly   310 V-CFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHD--VELQWRL 371
            : |.:.|||.::|:..:..||.|||||::||..||.:.:|.|....:...:....:  .|..:|.
 Frog   236 ILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYTAGFLLEERGVCVERFSEDSYRT 300

  Fly   372 MRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPL 436
            :..| .....|...::...:..:.::.||:|.:|.::|::..||..||:|..|..||:.||..|.
 Frog   301 VAQG-TKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPA 364

  Fly   437 APPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQ 493
            ...|..|.:.:|....|:|:||.        .|||..|..|.|.:|..|.|....||..::    
 Frog   365 VKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIR---- 425

  Fly   494 PTLAHH------RFGQIRKRFVLFSLLYFAPTTAGVVAALCERYADS----------VPSCS--- 539
             |:..|      :..::..|..:||::|..|.|   :...|..|..:          |.:|.   
 Frog   426 -TIMKHDGTKTEKLEKLMVRIGVFSVMYTVPAT---IVLACYFYEQAFRDTWEKTWLVQTCKGFA 486

  Fly   540 --TPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYR---NRLGASG 590
              .|:...:|........:::....::.|..:..|:||.||.:|:|   :||...|
 Frog   487 VPCPNYNFAPMSPDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRLSNGG 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM_1 22..83 CDD:425453
CRD_FZ <138..224 CDD:470581 27/89 (30%)
7tmF_FZD3_insect 290..587 CDD:320159 84/335 (25%)
TM helix 1 299..324 CDD:320159 9/29 (31%)
TM helix 2 333..354 CDD:320159 9/20 (45%)
TM helix 3 383..409 CDD:320159 4/25 (16%)
TM helix 4 426..442 CDD:320159 6/15 (40%)
TM helix 5 469..493 CDD:320159 7/23 (30%)
TM helix 6 513..540 CDD:320159 7/41 (17%)
TM helix 7 548..573 CDD:320159 1/24 (4%)
fzd7NP_001016741.1 CRD_FZ7 32..156 CDD:143575 29/101 (29%)
7tmF_FZD7 217..547 CDD:320374 86/335 (26%)
TM helix 1 226..251 CDD:320374 8/24 (33%)
TM helix 2 260..281 CDD:320374 9/20 (45%)
TM helix 3 311..337 CDD:320374 4/25 (16%)
TM helix 4 354..370 CDD:320374 6/15 (40%)
TM helix 5 392..421 CDD:320374 9/28 (32%)
TM helix 6 441..468 CDD:320374 8/29 (28%)
TM helix 7 497..522 CDD:320374 1/24 (4%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 526..531 2/4 (50%)
PDZ-binding. /evidence=ECO:0000255 546..548
Blue background indicates that the domain is not in the aligned region.

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