DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and Corin

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_058565.2	Gene:	Corin / 53419	MGIID:	1349451	Length:	1113	Species:	Mus musculus

Alignment Length:	171	Identity:	36/171 - (21%)
Similarity:	58/171 - (33%)	Gaps:	56/171 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IEALNHSTFKSKDILVSNAS-FRSLKANCCVYAP-------------PKKKRMIAWSDADDVSIV 119
            :|:...|:....|..:||.| ...:....|:..|             .:|:..|:|.
Mouse   502 VESCAGSSLCDSDSSLSNCSQCEPITLELCMNLPYNHTHYPNYLGHRTQKEASISWE-------- 558

  Fly   120 ERNEDEDDDDYKSDDEKGQIAKLVP-LIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCET 183
                                :.|.| |:::.|.:...|..|:.|.|.|..:..:.:..|:||||.
Mouse   559 --------------------SSLFPALVQTNCYKYLMFFACTILVPKCDVNTGQRIPPCRLLCEH 603

  Fly   184 VRGECMENAPPELMELWPSFLNCDGLPQPEKHELCMQIPQE 224
            .:..|            .|.|...||..||..: |.|.|:|
Mouse   604 SKERC------------ESVLGIVGLQWPEDTD-CNQFPEE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796	11/66 (17%)
		RRM_1	22..83	CDD:278504	3/13 (23%)
		CRD_FZ	<138..224	CDD:295308	24/86 (28%)
		Frizzled	291..584	CDD:279827
Corin	NP_058565.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..202
		CRD_corin_1	202..331	CDD:143554
		LDLa	337..372	CDD:238060
		LDLa	374..408	CDD:238060
		Ldl_recept_a	415..445	CDD:278486
		LDLa	455..482	CDD:238060
		CRD_corin_2	522..643	CDD:143579	30/151 (20%)
		Ldl_recept_a	648..682	CDD:278486
		LDLa	<695..720	CDD:238060
		LDLa	723..757	CDD:238060
		SR	758..853	CDD:214555
		Tryp_SPc	868..1097	CDD:214473
		Tryp_SPc	869..1100	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900