DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz3 and fzd2

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001008449.1	Gene:	fzd2 / 493345	XenbaseID:	XB-GENE-487022	Length:	553	Species:	Xenopus tropicalis

Alignment Length:	511	Identity:	132/511 - (25%)
Similarity:	215/511 - (42%)	Gaps:	101/511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||...||.|||...|:||. :.:.:..|:.:||..|..|     ..||
Frog    68 EDAGLEVHQFYPLVKVQCSSELRFFLCSMYAPVCTV-LEQAIPPCRSICERARHGC-----EALM 126

  Fly   198 E----LWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGS---PSGPPTTGSPG-----VEDHPQTY 250
            .    .||..|.|:..|:....::|  :.|..:..||.   .:.||..|:||     ..|||
Frog   127 NKFGFQWPERLRCENFPRHGAEQIC--VGQNHSEDGGPTLLTTSPPHHGTPGPPIYATLDHP--- 186

  Fly   251 RFWKSGASPTSDLAGVLCPQ----------NFSGSPFNPEECVPQCQ---RDAFHTSSQK--KTS 300
                           ..||:          .|.|.    ::|...|:   .|.|...||.  :.:
Frog   187 ---------------FHCPRVLKVPSYLNYRFLGE----KDCAAPCEPSKNDGFMFFSQDEIRFA 232

  Fly   301 ETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHD- 364
            ...||..|.:|...|.|.:.|:..:..||.|||||::||..||.:.||.|:...|..|:...::
Frog   233 RVWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLGNKVVCNEN 297

  Fly   365 -VELQWRLM-----RPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKR 423
             .|..::.:     :.||.:.      ::...:.|:.::.||:|.:|.::|::..||..||:|..
Frog   298 FSEGGYKTVVQGTKKEGCTIL------FMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEAN 356

  Fly   424 SGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLR 480
            |..||:.||..|....|..|.:.::....|:|:|:.        .|||..|..|.|.:|..|.|.
Frog   357 SQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGTSFLLA 421

  Fly   481 ASRSLLSLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGVVAALCER-YADSVPSC 538
            ...||..::     |:..|      :..::..|..:||:||..|.|..:.....|: :.:.....
Frog   422 GFVSLFRIR-----TIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERS 481

  Fly   539 STPDDCLS---PTPLSAWPA--------LVRIFFQLVGGTLTGLWVWSRKTCESYR 583
            ....:|.|   |.||...|.        :::....|:.|..:|.|:||.||..|:|
Frog   482 WVSQNCKSLAIPCPLQYTPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWR 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	25/89 (28%)
		Frizzled	291..584	CDD:279827	88/328 (27%)
fzd2	NP_001008449.1	Frizzled	223..540	CDD:279827	87/326 (27%)
fzd2	NP_001008449.1	CRD_FZ2	36..162	CDD:143573	28/101 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010