Protein Alignment fz3 and Fzd8

DIOPT Version :10

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001037716.1
• Gene: Fzd8 / 364754
• RGDID: 1560525
• Length: 684
• Species: Rattus norvegicus
• Alignment Length: 581
• Identity: 155/581 - (26%)
• Similarity: 227/581 - (39%)
• Gaps: 153/581 - (26%)

  Fly   129 DYKSDDEKG-QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENA 192
            ::.:.||.| ::.:..||:|..||...:|.|||...|:|..|..:|:..|:.:||..:..|   |
  Rat    58 NHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGC---A 119

  Fly   193 PPELME----LWPSFLNCDGLP-QPEKHELCMQI------------PQEVAVP------------ 228
            |  ||.    .||..:.||.|| |.....|||..            |:.:..|
  Rat   120 P--LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGSGH 182

  Fly   229 -----------GGSPSG-------PPTTGS----PGVEDHPQTYRFWKSGASPTSDLAGVLCPQN 271
                       |||..|       ||:.|.    ||            .||:|.........|..
  Rat   183 SRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPG------------GGAAPCEPGCQCRAPMV 235

  Fly   272 FSGSPFNP----------EECVPQCQRDAFHTSSQKKTSETLI-LGL-SAVCFVLTLFALVTFWA 324
            ...|..:|          ..|...|....|   ||.:.:.|:. :|| |.:|||.|...:.||..
  Rat   236 SVSSERHPLYNRVKTGQIANCALPCHNPFF---SQDERAFTVFWIGLWSVLCFVSTFATVSTFLI 297

  Fly   325 EPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQ------------------------------ 359
            :..||.|||||::||..||...||.||.|:|..::
  Rat   298 DMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGA 362

  Fly   360 ------AR-----MHDVELQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHK 413
                  ||     :..||...|....|..|   |...::...:..:.::.||:|.:|.::|::..
  Rat   363 GASSPGARGEYEELGAVEQHVRYETTGPAL---CTVVFLLVYFFGMASSIWWVILSLTWFLAAGM 424

  Fly   414 KWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVL 470
            ||.:||:...|..||:.||:.|....||.|.|..|....:.|:||.        .|||..|.::.
  Rat   425 KWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIY 489

  Fly   471 LLLGLYFTLRASRSLLS----LQQQLQPTLAHHRFGQIRKRFVLFSLLYFAPTTAGVVAALCERY 531
            |.:|..|.|....||..    ::||..||.. |:..::..|..||::||..|....|.....|::
  Rat   490 LFIGTMFLLAGFVSLFRIRSVIKQQGGPTKT-HKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQH 553

  Fly   532 A----DSVPSCS-----TPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYR 583
            .    ::..:|.     .||....|   .....:::.|..||.|..:|:||||.||.||:|
  Rat   554 NRPRWEATHNCPCLRDLQPDQARRP---DYAVFMLKYFMCLVVGITSGVWVWSGKTLESWR 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM_1	22..83	CDD:425453
		CRD_FZ	<138..224	CDD:470581	32/102 (31%)
		7tmF_FZD3_insect	290..587	CDD:320159	102/358 (28%)
		TM helix 1	299..324	CDD:320159	10/26 (38%)
		TM helix 2	333..354	CDD:320159	11/20 (55%)
		TM helix 3	383..409	CDD:320159	4/25 (16%)
		TM helix 4	426..442	CDD:320159	6/15 (40%)
		TM helix 5	469..493	CDD:320159	8/27 (30%)
		TM helix 6	513..540	CDD:320159	6/35 (17%)
		TM helix 7	548..573	CDD:320159	5/24 (21%)
Fzd8	NP_001037716.1	CRD_FZ8	31..155	CDD:143570	34/101 (34%)
		Wnt-binding. /evidence=ECO:0000250	95..100		1/4 (25%)
		Wnt-binding. /evidence=ECO:0000250	147..152		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..222		12/78 (15%)
		7tmF_FZD8	263..615	CDD:320378	102/359 (28%)
		TM helix 1	272..297	CDD:320378	10/24 (42%)
		TM helix 2	306..327	CDD:320378	11/20 (55%)
		TM helix 3	394..416	CDD:320378	3/21 (14%)
		TM helix 4	437..453	CDD:320378	6/15 (40%)
		TM helix 5	475..498	CDD:320378	7/22 (32%)
		TM helix 6	528..553	CDD:320378	8/24 (33%)
		TM helix 7	576..601	CDD:320378	6/27 (22%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	605..610		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	630..655
		PDZ-binding. /evidence=ECO:0000250	682..684