DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz3 and Fzd10

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001258121.1	Gene:	Fzd10 / 363913	RGDID:	1583825	Length:	582	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	156/541 - (28%)
Similarity:	247/541 - (45%)	Gaps:	91/541 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELME---- 198
            |:.:..||:|.||....||.|||...|:||..|..|:.||:::||..|.:|   :|  :||
  Rat    68 QLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKC---SP--IMEQFKF 127

  Fly   199 LWPSFLNCDGLP-QPEKHELCMQIPQEVAVPGGSPSGPPTTGS------------PGVEDHPQTY 250
            .||..|:|..|| :.:.:.|||:.|       .:.|..|:.||            ...::||
  Rat   128 RWPDSLDCSKLPNKNDPNYLCMEAP-------NNGSDEPSRGSGMFPPLFRPQRPHSAQEHP--- 182

  Fly   251 RFWKSGASPTSDLAGVLCPQNFSGSPFNPEECVPQCQR--DAFHTSSQKKTSETLILGLSAVCFV 313
              .|.|.   ...||...|..|.... ..|.|.|.|..  |.:.:...|:.:...:...|.:||.
  Rat   183 --LKDGG---PGRAGCDNPGKFHHVE-KSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFF 241

  Fly   314 LTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE------LQWRLM 372
            .:.|.::||..:|:||.|||||::||.:||.::||.|:.|:....::...|.:      :|..|.
  Rat   242 SSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLE 306

  Fly   373 RPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLA 437
            ..||.|.      ::...|..:.::.||::..|.::|::.:||..||:|..|..||:.||..|..
  Rat   307 STGCTLV------FLVLYYFGMASSLWWVVLTLTWFLAAGRKWGHEAIEANSSYFHLAAWAIPAV 365

  Fly   438 PPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQP 494
            ..|..|::.:|...||||:||.        .|||.:|....|::|..|.|....:|..:::.::.
  Rat   366 KTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKT 430

  Fly   495 TLAH-HRFGQIRKRFVLFSLLYFAPTTAGVVAALCER----YADSVPS---CSTPD-----DCLS 546
            ...: .:..::..|..:|||||..|.|..:.....||    |...:.:   |.|.:     |||.
  Rat   431 GGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKTNNQTKTADCLM 495

  Fly   547 PTPLSAWPA-LVRIFFQLVGGTLTGLWVWSRKTCESYR-----------NRLGASGTPTSSLMNQ 599
            .|.:.|... :|::...||.|..:|:|||:.||.:|::           .|..||...::.:.
  Rat   496 TTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQQVCSRGLKRKSRRKPASVVTSAGIY-- 558

  Fly   600 SKAAGALPKKHLYTSGKSMLP 620
             |.|....|.||   ||..||
  Rat   559 -KKAQHPQKPHL---GKYELP 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	35/90 (39%)
		Frizzled	291..584	CDD:279827	92/331 (28%)
Fzd10	NP_001258121.1	CRD_FZ	31..157	CDD:295308	35/100 (35%)
Fzd10	NP_001258121.1	Frizzled	219..536	CDD:279827	92/322 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010