Protein Alignment fz3 and Smo

DIOPT Version :9

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_795970.3
• Gene: Smo / 319757
• MGIID: 108075
• Length: 793
• Species: Mus musculus
• Alignment Length: 560
• Identity: 130/560 - (23%)
• Similarity: 203/560 - (36%)
• Gaps: 108/560 - (19%)

  Fly   132 SDDEKGQIAKLVPLIESGCSRRARF------LLCSSLFPLCTPDVPRPVAACKLLCETVRGECME 190
            ||.::....|||  :.||.....|.      |||:...|.|..|  |.....:.||:..||.|
Mouse   100 SDSQEEAHGKLV--LWSGLRNAPRCWAVIQPLLCAVYMPKCEND--RVELPSRTLCQATRGPC-- 158

  Fly   191 NAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKS 255
             |..|....||.||.|                    .|...|.|.|        :..|..:|..|
Mouse   159 -AIVERERGWPDFLRC--------------------TPDHFPEGCP--------NEVQNIKFNSS 194

  Fly   256 GASPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALV 320
            |...    |.::...|......:.|.|..|||...| |.::.:...:.|....||..:.|||.|.
Mouse   195 GQCE----APLVRTDNPKSWYEDVEGCGIQCQNPLF-TEAEHQDMHSYIAAFGAVTGLCTLFTLA 254

  Fly   321 TF---WAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDV---ELQWRLMRPGCLLT 379
            ||   |....|  ||...:.::..|:.:.|:.:|.:  |.:.||...|   :...|...|....|
Mouse   255 TFVADWRNSNR--YPAVILFYVNACFFVGSIGWLAQ--FMDGARREIVCRADGTMRFGEPTSSET 315

  Fly   380 PPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSS-EALEKRSGLFHVLAWVPPLAPPIAAL 443
            ..|:..::...|..:....|:::....::.|.....:: :.|..::..||:|.|..|....:|.|
Mouse   316 LSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAIL 380

  Fly   444 LLEKVRPSELTGMC--------YAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHR 500
            .:.:|....::|:|        |..|||..|..::|::|.||.:|...:|.|::......|:...
Mouse   381 AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKA 445

  Fly   501 FGQIRK---RFVLFSLLYFAPTTAGVVA-----------------------ALCE-RYADSVPSC 538
            ..:|.:   |..:|..|.|     |.|.                       .||: .....:|:.
Mouse   446 ASKINETMLRLGIFGFLAF-----GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTK 505

  Fly   539 STPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRN---RL-GASGTPTSSLMNQ 599
            ....||......|.....:.:|.....|.....|||::.|...:|.   || |.|......:...
Mouse   506 KPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKS 570

  Fly   600 SKAAGALPKKH--LYTSGK----SMLPTGGITPLYAGISF 633
            ...|.|..|:.  |...|:    ||.......|: ||::|
Mouse   571 KMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPV-AGLAF 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	25/91 (27%)
		Frizzled	291..584	CDD:279827	72/334 (22%)
Smo	NP_795970.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..61
		CRD_SMO	70..200	CDD:143560	35/138 (25%)
		Frizzled	225..554	CDD:279827	73/338 (22%)
		Interaction with BBS5 and BBS7. /evidence=ECO:0000269|PubMed:22072986	542..573		6/30 (20%)
		Interaction with DLG5. /evidence=ECO:0000269|PubMed:25644602	585..597		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..703

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820