DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and CG1632

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster

Alignment Length:	675	Identity:	128/675 - (18%)
Similarity:	194/675 - (28%)	Gaps:	258/675 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGSDIAGIKLTSGPTSLRSRILVRNLPP--CTREELSFLCYPFGTILGSLVIDNHGFIQFATER 63
            ||.|.:.|...|:.|.     :.....||  |:..|||: |...|
  Fly   359 MSSSPLGGHDETTEPV-----VTTTPAPPRRCSPLELSY-CRQVG-------------------- 397

  Fly    64 EATRAIEALNHSTFKSKDILVSNASFRSLKANCCVYAPPKKKRMIAWSDADDVSIVERNEDEDDD 128
                    .|.:|:.:   |:.:||:..|                    |:|| ||.|.
  Fly   398 --------YNITTYPN---LLGHASYEQL--------------------AEDV-IVFRE------ 424

  Fly   129 DYKSDDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCT---PDV-PRPVAACKLLCETVRGECM 189
                            |::..|.|.|...:|..|.|.|.   .|: |.|...|:..||:....|.
  Fly   425 ----------------LVDGECHREAYDFVCRLLQPPCDTHGSDLQPTPGQICREYCESFMAGCG 473

  Fly   190 ENAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWK 254
            ...|....:    |.:|:..|:....:.|.|.|..|:....:...|..  ..|..|.|..
  Fly   474 GRLPQRFRQ----FFDCERFPESTGTQSCHQKPHCVSDMQSNVQSPRL--CDGYADCPDL----- 527

  Fly   255 SGASPTSDLAGVLCPQN--FSGSPFNPEECVPQCQR-----DAFHTSSQKKTSETLILGLSAVCF 312
                 :.:.:...|..|  :.|   ....|||:..|     |....:.:|.            |.
  Fly   528 -----SDERSCAFCSPNALYCG---RGRACVPRKARCDGKADCPDGADEKD------------CL 572

  Fly   313 VLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCL 377
            .:...|......||.                    |.||.|  ||:
  Fly   573 SIAPLAADLLQPEPL--------------------VPYLSR--FHS------------------- 596

  Fly   378 LTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAA 442
                  |.|...|...       ::..||          :|.||..:.|.
  Fly   597 ------AGYAVFSEKG-------VVGKLC----------AEGLEGDAKLV--------------- 623

  Fly   443 LLLEKVRPSELTGMCYAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHRFGQIRKR 507
                 ||.:....:|.:.|:..:.        ::.....:..|....:.|.|......|  ||..
  Fly   624 -----VRQTVSESLCKSLGYESVE--------IFDVQNDTERLNDYVRVLDPHAPEISF--IRTH 673

  Fly   508 FVLFSLLYF--APTTAGVVAALCE-RYADSVPSCSTPDDCLSPTPLSAWPALVRIF---FQLVGG 566
            .....:||.  .....||.:||.. :...|:|..|.|.|         ||.||.:|   ..:..|
  Fly   674 CPRRQVLYVGCGELRCGVQSALFNAKQHLSLPKMSAPGD---------WPWLVALFREDIHVCDG 729

  Fly   567 TL-TGLWVWSRKTCESYRNRLGASGTPTSSLMNQSKAAGA--LPKKHLYTSGKSML--------- 619
            || |..||.:.:.|        ..|.|.::.|   ...||  |..|..:|..:.::
  Fly   730 TLITQDWVLTTEGC--------FQGQPRATWM---AIVGAVRLSAKAPWTQRRRIIGMIKSPVEG 783

  Fly   620 PTGGITPLYAGISF--HNVPVYNPN 642
            .|..:..|...:|:  |..|:..|:
  Fly   784 STAALVRLETPVSYSDHVRPICLPD 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796	19/104 (18%)
		RRM_1	22..83	CDD:278504	10/62 (16%)
		CRD_FZ	<138..224	CDD:295308	22/89 (25%)
		Frizzled	291..584	CDD:279827	53/299 (18%)
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	39/196 (20%)
		PRKCSH-like	<503..>582	CDD:193472	16/105 (15%)
		LDLa	536..571	CDD:238060	9/49 (18%)
		Tryp_SPc	708..>809	CDD:304450	29/121 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900