DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and fzd7b

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_739569.1	Gene:	fzd7b / 30412	ZFINID:	ZDB-GENE-990415-229	Length:	557	Species:	Danio rerio

Alignment Length:	522	Identity:	139/522 - (26%)
Similarity:	221/522 - (42%)	Gaps:	112/522 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||:..:|.|||...|:||. :.:.:..|:.|||..|..|     ..||
Zfish    73 EDAGLEVHQFYPLVKVQCSQDLKFFLCSMYAPVCTV-LEQAIPPCRTLCERARQGC-----EALM 131

  Fly   198 E----LWPSFLNCDGLPQPEKHELCM-QIPQEVAVPGGSPSGP--PTTGSPGVEDHPQTYRFWKS 255
            .    .||..|.|:..|.....|:|: |...:..||..:|: |  |...||.:....|...|
Zfish   132 NKFGFQWPERLRCENFPVHGAGEICVGQNKSDPDVPTTNPT-PYIPEPFSPRIHTPRQNQAF--- 192

  Fly   256 GASPTSDLAGVLCP----------QNFSGSPFNPEECVPQCQRDAFHTSSQKKTSET----LILG 306
                       .||          .:|.|:    :.|...|:....:.....|..|.    |.:|
Zfish   193 -----------TCPLQLTVPSYLNYHFLGA----KNCGAPCEHKQPYGLMYFKEEEVRFGRLWVG 242

  Fly   307 L-SAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWR 370
            : |.:|.|.|||.::|:..:..||.|||||::||..||.:.:|.|....:..::....|   ::|
Zfish   243 IWSILCCVSTLFTVLTYLVDMRRFHYPERPIIFLSGCYFMVAVAYAAGFLLEDKVVCID---KFR 304

  Fly   371 ----------LMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSG 425
                      ..:.||.:.      ::...:..:.::.||:|.:|.::||:..||..||:|..|.
Zfish   305 DDAFKTVAQGTKKEGCTIL------FMVLYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQ 363

  Fly   426 LFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRAS 482
            .||:.||..|....|..|.|.:|....|||:||.        .|||..|..|.|.:|..|.|...
Zfish   364 YFHLAAWAVPAVKTITILALGQVDGDLLTGVCYVGIYNVDALRGFVLAPLFVYLFIGTSFLLAGF 428

  Fly   483 RSLLSLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGVVAA--------------- 526
            .||..::     |:..|      :..::..|..:||:||..|.|. |:|.
Zfish   429 VSLFRIR-----TIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATI-VIACYFYEQAFREQWEKTW 487

  Fly   527 ---LCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYR---NR 585
               .|:|:|  || |  |::..:|........:::....::.|..:|.|:||.||.:|:|   .|
Zfish   488 HMQTCKRFA--VP-C--PNNNFAPMTPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKR 547

  Fly   586 LG 587
            ||
Zfish   548 LG 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	27/90 (30%)
		Frizzled	291..584	CDD:279827	93/342 (27%)
fzd7b	NP_739569.1	CRD_FZ1_like	43..161	CDD:143567	28/93 (30%)
fzd7b	NP_739569.1	Frizzled	228..545	CDD:279827	93/336 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750