DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and fzd4

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001292398.1	Gene:	fzd4 / 30363	ZFINID:	ZDB-GENE-990415-217	Length:	523	Species:	Danio rerio

Alignment Length:	492	Identity:	140/492 - (28%)
Similarity:	222/492 - (45%)	Gaps:	84/492 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 DEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELME 198
            |.:.|:....|||:.|||.:.:|.|||...|:||..||.|:..|..:|.:|:.:|:    |.|.|
Zfish    58 DAELQLTTFTPLIQYGCSSQLKFFLCSVYVPMCTEKVPIPIGPCGSMCMSVKRKCL----PVLQE 118

  Fly   199 ---LWPSFLNCDGLPQP-EKHELCMQIPQEVAVP--GGSPSGPP-----TTGSPGVEDHPQTYRF 252
               :||..|||...|.. :::.:||:.|.:...|  ...|..|.     ..|: |||.:....|
Zfish   119 FGFVWPELLNCSLFPPTNDQNHMCMEGPGDEDPPFHAVRPVAPQEEECIALGA-GVEQYAWVKR- 181

  Fly   253 WKSGASPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDAFHTSSQKKTSETLILGLSAV-CFVLTL 316
                                |||      |..||..|......|.|....:.:.:.|| ||:.|.
Zfish   182 --------------------SGS------CSLQCGYDTGLYRRQAKVFTDVWMAVWAVLCFISTT 220

  Fly   317 FALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE-------LQWRLMRP 374
            |.::||..:.:||.|||||::||.:|.|::||.::.|:....:....|:|       :|..|...
Zfish   221 FTVLTFLVDSSRFSYPERPIIFLSMCCNIYSVAFIVRLTVGRERISCDLEEAAVPVLVQEGLKNT 285

  Fly   375 GCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPP 439
            ||.:.      ::.|.:..:.::.||:|..|.::|::..||..||:|..|..||:.||..|....
Zfish   286 GCAIV------FLLTYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKT 344

  Fly   440 IAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPT- 495
            |..|::..|...:|.||||.        .|||..|....|::|..|......:|..::..||..
Zfish   345 IVILIMRLVDADDLAGMCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDG 409

  Fly   496 LAHHRFGQIRKRFVLFSLLYFAPTTAGVVAALCE--RYADSVPSCSTPDDCLSPTPLSAWPA--L 556
            ....:..::..:..:||:||..|.|..:.....|  .:||           ...|...::.|  :
Zfish   410 TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWAD-----------FRQTARDSYMAAEM 463

  Fly   557 VRIFFQLVGGTLTGLWVWSRKTCESYR---NRLGASG 590
            :|||..|:.|..:|:||||.||..:::   :||..:|
Zfish   464 LRIFMSLLVGITSGMWVWSAKTLHTWQRCSHRLVHTG 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	33/89 (37%)
		Frizzled	291..584	CDD:279827	88/316 (28%)
fzd4	NP_001292398.1	CRD_FZ4	26..150	CDD:143557	34/95 (36%)
fzd4	NP_001292398.1	Frizzled	195..492	CDD:279827	88/313 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920