Protein Alignment fz3 and Fzd6

DIOPT Version :9

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001124008.1
• Gene: Fzd6 / 282581
• RGDID: 628816
• Length: 710
• Species: Rattus norvegicus
• Alignment Length: 552
• Identity: 141/552 - (25%)
• Similarity: 222/552 - (40%)
• Gaps: 107/552 - (19%)

  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL--- 199
            ::...:||....||......||.:..|.||..:. .|:.|:.|||.:..:|.     :||:.
  Rat    57 EMEHFLPLANLECSPNIEMFLCQAFVPTCTEQID-VVSPCRKLCEKILSDCQ-----KLMDTFGI 115

  Fly   200 -WPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDH-PQTYRFWKSGASPTSD 262
             ||..|.|..||      .|     :.|||..|.......|.....|. |:...||
  Rat   116 RWPEELECHRLP------YC-----DGAVPVTSDPHTELFGPQKKTDQVPRDIGFW--------- 160

  Fly   263 LAGVLCPQNF--SGSP----FNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVT 321
                 ||::.  ||..    ...::|.|.|. :.:..|.:...:::.|..:|..|...|||..:|
  Rat   161 -----CPKHLRTSGDQGYRFLGIDQCAPPCP-NMYFKSDELDFAKSFIGIVSIFCLCATLFTFLT 219

  Fly   322 FWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCL--LTPPCLA 384
            |..:..||.|||||:::..:||::.|:.|....:..|....:..:.:..|.....|  ....|..
  Rat   220 FLIDVRRFRYPERPIIYYSVCYSIVSLMYFVGFLLGNSTACNKADEKLELGNTVVLGSKNKACSV 284

  Fly   385 SYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVR 449
            .::...:.::....||:|..:.::|::.:|||.||:|:::..||.:||..|....:..|.:.||.
  Rat   285 VFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGMPGFLTVMLLAMNKVE 349

  Fly   450 PSELTGMCY--------APGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHRFGQIR- 505
            ...::|:|:        :..||.||..:.:.:||...|....||..::|.:|    |....|.:
  Rat   350 GDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQ----HDGRNQEKL 410

  Fly   506 KRFVL----FSLLYFAP--TTAG-VVAALCERYADSVPSCSTPDDCLS---PTPLSAWPA----- 555
            |:|::    ||.||..|  |..| .|..|..|....:...|  |.|..   |.|..|.|.
  Rat   411 KKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRVTWEMTWFS--DHCHQYRIPCPYQANPKARPEL 473

  Fly   556 ---LVRIFFQLVGGTLTGLWVWSRKTCESY-----RNRLGASGTPTSS------------LMNQS 600
               :::....|:.|.....||.|:|||..:     |||   ...|.|.            |.:.|
  Rat   474 ALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFCKRNR---KRDPISESRRVLQESCEFFLKHNS 535

  Fly   601 KAAGALPKKH-------LYTSGKSMLPTGGIT 625
            |...  .|||       |....|||..:.|:|
  Rat   536 KVRH--KKKHGKPGSHKLKVISKSMGTSTGVT 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	24/89 (27%)
		Frizzled	291..584	CDD:279827	84/326 (26%)
Fzd6	NP_001124008.1	CRD_FZ6	20..146	CDD:143559	28/105 (27%)
		7tmF_FZD6	188..508	CDD:320160	84/325 (26%)
		TM helix 1	198..222	CDD:320160	8/23 (35%)
		TM helix 2	231..252	CDD:320160	7/20 (35%)
		TM helix 3	283..305	CDD:320160	3/21 (14%)
		TM helix 4	326..342	CDD:320160	5/15 (33%)
		TM helix 5	364..387	CDD:320160	6/22 (27%)
		TM helix 6	418..440	CDD:320160	8/21 (38%)
		TM helix 7	469..494	CDD:320160	2/24 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820