| Sequence 1: | NP_001096859.1 | Gene: | fz3 / 31023 | FlyBaseID: | FBgn0027343 | Length: | 646 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001457.1 | Gene: | FZD2 / 2535 | HGNCID: | 4040 | Length: | 565 | Species: | Homo sapiens |
| Alignment Length: | 531 | Identity: | 133/531 - (25%) |
|---|---|---|---|
| Similarity: | 218/531 - (41%) | Gaps: | 128/531 - (24%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
Fly 198 E----LWPSFLNCDGLPQPEKHELCM-QIPQEVAVP---------------GGSPSGPPTTGSP- 241
Fly 242 --GVEDHPQTYRFWKSGASPTSDLAGVLCPQ----------NFSGSPFNPEECVPQCQ-----RD 289
Fly 290 AFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYL--- 351
Fly 352 ---ERIVFHNQARMHDVELQWRLM-----RPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFY 408
Fly 409 LSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVEL 465
Fly 466 PALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGV- 523
Fly 524 ----------------VAALCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLW 572
Fly 573 VWSRKTCESYR 583 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| fz3 | NP_001096859.1 | RRM | <19..>122 | CDD:223796 | |
| RRM_1 | 22..83 | CDD:278504 | |||
| CRD_FZ | <138..224 | CDD:295308 | 26/90 (29%) | ||
| Frizzled | 291..584 | CDD:279827 | 89/335 (27%) | ||
| FZD2 | NP_001457.1 | CRD_FZ2 | 35..161 | CDD:143573 | 28/99 (28%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 160..189 | 7/28 (25%) | |||
| 7tmF_FZD2 | 234..563 | CDD:320373 | 89/336 (26%) | ||
| TM helix 1 | 244..268 | CDD:320373 | 7/23 (30%) | ||
| TM helix 2 | 277..298 | CDD:320373 | 10/20 (50%) | ||
| TM helix 3 | 328..350 | CDD:320373 | 4/27 (15%) | ||
| TM helix 4 | 371..387 | CDD:320373 | 6/15 (40%) | ||
| TM helix 5 | 409..432 | CDD:320373 | 8/22 (36%) | ||
| TM helix 6 | 463..485 | CDD:320373 | 6/21 (29%) | ||
| TM helix 7 | 514..539 | CDD:320373 | 5/27 (19%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 543..548 | 2/4 (50%) | |||
| PDZ-binding | 563..565 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165141194 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D167933at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.750 | |||||