DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fz3 and Smo

DIOPT Version :9

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_036939.1 Gene:Smo / 25273 RGDID:3726 Length:793 Species:Rattus norvegicus


Alignment Length:565 Identity:132/565 - (23%)
Similarity:206/565 - (36%) Gaps:109/565 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 SDDEKGQIAKLVPLIESGCSRRARF------LLCSSLFPLCTPDVPRPVAACKLLCETVRGECME 190
            ||.::...:|||  :.||.....|.      |||:...|.|..|  |.....:.||:..||.|  
  Rat   100 SDSQEEAHSKLV--LWSGLRNAPRCWAVIQPLLCAVYMPKCEND--RVELPSRTLCQATRGPC-- 158

  Fly   191 NAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKS 255
             |..|....||.||.|                    .|...|.|.|        :..|..:|..|
  Rat   159 -AIVERERGWPDFLRC--------------------TPDHFPEGCP--------NEVQNIKFNSS 194

  Fly   256 GASPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALV 320
            |...    |.::...|......:.|.|..|||...| |.::.:...:.|....||..:.|||.|.
  Rat   195 GQCE----APLVRTDNPKSWYEDVEGCGIQCQNPLF-TEAEHQDMHSYIAAFGAVTGLCTLFTLA 254

  Fly   321 TF---WAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDV---ELQWRLMRPGCLLT 379
            ||   |....|  ||...:.::..|:.:.|:.:|.:  |.:.||...|   :...|...|....|
  Rat   255 TFVADWRNSNR--YPAVILFYVNACFFVGSIGWLAQ--FMDGARREIVCRADGTMRFGEPTSSET 315

  Fly   380 PPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSS-EALEKRSGLFHVLAWVPPLAPPIAAL 443
            ..|:..::...|..:....|:::....::.|.....:: :.|..::..||:|.|..|....:|.|
  Rat   316 LSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAIL 380

  Fly   444 LLEKVRPSELTGMC--------YAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHR 500
            .:.:|....::|:|        |..|||..|..::|::|.||.:|...:|.|::......|:...
  Rat   381 AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKA 445

  Fly   501 FGQIRK---RFVLFSLLYFAPTTAGVVA-----------------------ALCE-RYADSVPSC 538
            ..:|.:   |..:|..|.|     |.|.                       .||: .....:|:.
  Rat   446 ASKINETMLRLGIFGFLAF-----GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTK 505

  Fly   539 STPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRN---RL-GASGTPTSSLMNQ 599
            ....||......|.....:.:|.....|.....|||::.|...:|.   || |.|......:...
  Rat   506 KPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKS 570

  Fly   600 SKAAGALPKKH--LYTSGK----SMLPTGGITPLYAGISFH-NVP 637
            ...|.|..|:.  |...|:    ||.......|: ||::|. |.|
  Rat   571 KMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPV-AGLAFELNEP 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM <19..>122 CDD:223796
RRM_1 22..83 CDD:278504
CRD_FZ <138..224 CDD:295308 25/91 (27%)
Frizzled 291..584 CDD:279827 72/334 (22%)
SmoNP_036939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..61
CRD_SMO 70..200 CDD:143560 35/138 (25%)
Frizzled 225..554 CDD:279827 73/338 (22%)
Interaction with BBS5 and BBS7. /evidence=ECO:0000250|UniProtKB:P56726 542..573 6/30 (20%)
Interaction with DLG5. /evidence=ECO:0000250|UniProtKB:P56726 585..597 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..702
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D509772at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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