Protein Alignment fz3 and Smo

DIOPT Version :10

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_036939.2
• Gene: Smo / 25273
• RGDID: 3726
• Length: 793
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 132/565 - (23%)
• Similarity: 207/565 - (36%)
• Gaps: 109/565 - (19%)

  Fly   132 SDDEKGQIAKLVPLIESGCSRRARF------LLCSSLFPLCTPDVPRPVAACKLLCETVRGECME 190
            ||.::...:|||  :.||.....|.      |||:...|.|..|  |.....:.||:..||.|
  Rat   100 SDSQEEAHSKLV--LWSGLRNAPRCWAVIQPLLCAVYMPKCEND--RVELPSRTLCQATRGPC-- 158

  Fly   191 NAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKS 255
             |..|....||.||.|                    :|...|.|.|        :..|..:|..|
  Rat   159 -AIVERERGWPDFLRC--------------------MPDHFPEGCP--------NEVQNIKFNSS 194

  Fly   256 GASPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALV 320
            |...    |.::...|......:.|.|..|||...| |.::.:...:.|....||..:.|||.|.
  Rat   195 GQCE----APLVRTDNPKSWYEDVEGCGIQCQNPLF-TEAEHQDMHSYIAAFGAVTGLCTLFTLA 254

  Fly   321 TF---WAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDV---ELQWRLMRPGCLLT 379
            ||   |....|  ||...:.::..|:.:.|:.:|.:  |.:.||...|   :...|...|....|
  Rat   255 TFVADWRNSNR--YPAVILFYVNACFFVGSIGWLAQ--FMDGARREIVCRADGTMRFGEPTSSET 315

  Fly   380 PPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSS-EALEKRSGLFHVLAWVPPLAPPIAAL 443
            ..|:..::...|..:....|:::....::.|.....:: :.|..::..||:|.|..|....:|.|
  Rat   316 LSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAIL 380

  Fly   444 LLEKVRPSELTGMC--------YAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHR 500
            .:.:|....::|:|        |..|||..|..::|::|.||.:|...:|.|::......|:...
  Rat   381 AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKA 445

  Fly   501 FGQIRK---RFVLFSLLYFAPTTAGVVA-----------------------ALCE-RYADSVPSC 538
            ..:|.:   |..:|..|.|     |.|.                       .||: .....:|:.
  Rat   446 ASKINETMLRLGIFGFLAF-----GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTK 505

  Fly   539 STPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRN---RL-GASGTPTSSLMNQ 599
            ....||......|.....:.:|.....|.....|||::.|...:|.   || |.|......:...
  Rat   506 KPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKS 570

  Fly   600 SKAAGALPKKH--LYTSGK----SMLPTGGITPLYAGISFH-NVP 637
            ...|.|..|:.  |...|:    ||.......|: ||::|. |.|
  Rat   571 KMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPV-AGLAFELNEP 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM_1	22..83	CDD:425453
		CRD_FZ	<138..224	CDD:470581	25/91 (27%)
		7tmF_FZD3_insect	290..587	CDD:320159	75/342 (22%)
		TM helix 1	299..324	CDD:320159	9/27 (33%)
		TM helix 2	333..354	CDD:320159	3/20 (15%)
		TM helix 3	383..409	CDD:320159	2/25 (8%)
		TM helix 4	426..442	CDD:320159	5/15 (33%)
		TM helix 5	469..493	CDD:320159	7/23 (30%)
		TM helix 6	513..540	CDD:320159	7/50 (14%)
		TM helix 7	548..573	CDD:320159	3/24 (13%)
Smo	NP_036939.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..61
		CRD_SMO	70..200	CDD:143560	35/138 (25%)
		7tmF_SMO_homolog	224..554	CDD:320158	73/339 (22%)
		TM helix 1	233..258	CDD:320158	9/24 (38%)
		TM helix 2	268..289	CDD:320158	3/22 (14%)
		TM helix 3	319..345	CDD:320158	2/25 (8%)
		TM helix 4	363..379	CDD:320158	5/15 (33%)
		TM helix 5	401..430	CDD:320158	10/28 (36%)
		TM helix 6	452..479	CDD:320158	6/31 (19%)
		TM helix 7	515..540	CDD:320158	3/24 (13%)
		Interaction with BBS5 and BBS7. /evidence=ECO:0000250|UniProtKB:P56726	542..573		6/30 (20%)
		Required for interaction with PRKACA. /evidence=ECO:0000250|UniProtKB:P56726	574..657		13/42 (31%)
		Interaction with DLG5. /evidence=ECO:0000250|UniProtKB:P56726	585..597		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..702