DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz3 and lin-17

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001021813.1	Gene:	lin-17 / 171832	WormBaseID:	WBGene00003006	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	473	Identity:	130/473 - (27%)
Similarity:	202/473 - (42%)	Gaps:	67/473 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL----WPSFL 204
            ||:::.|.....|.:||...|:|...:|:.|.:||.:||.|:.:|.     .::|.    ||..|
Worm    67 PLMKTKCHPHIHFFICSVFAPMCPIGMPQAVTSCKSVCEQVKADCF-----SILEEFGIGWPEPL 126

  Fly   205 NCDGLPQPEKHELCMQIPQEVAVPGGSPSGP--PTTGSPGVEDHPQTYRFWKSGASPT---SDLA 264
            ||...|.|.  ||||: |.|..:.||. |.|  ||.||.            .|.:.||   |||.
Worm   127 NCAQFPDPP--ELCMK-PTEDEITGGF-SAPRLPTKGSS------------SSSSKPTGCPSDLV 175

  Fly   265 GVLCPQNFSGSPFNPE-ECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTR 328
            .|        .|.:|: .|...||.:...::..|:...:..:..:|....:.||:.:||..:..|
Worm   176 DV--------DPHDPKSHCAFACQSNVMFSTDNKRMVRSWSIWFAAANAGVALFSFLTFAIDRKR 232

  Fly   329 FGYPERPVLFLCLCYNLFSVCYLERIVFHNQAR-MHDVELQWRLMRPGCLLTPPCLASYITTSYL 392
            |.:|||.|.:|.||..:.|:.||..:......| .|.:......:..|......||||::...:.
Worm   233 FRFPERCVFYLSLCIFISSLPYLTPLFIDAPIRSCHALGNGRSYLSIGTFDNSYCLASFLLNYFF 297

  Fly   393 SLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMC 457
            |..||.|||:|:...|||..:||..|.:|..|...|.:||.......|..|:..||..||||.:|
Worm   298 STAAALWWLMFSFTLYLSGGRKWVPEGIEACSSYVHFVAWGLSSLATIIVLIFNKVDASELTALC 362

  Fly   458 YAPG--------FVELPALVLLLLGLYFTLRASRSL----LSLQQQLQPTLAHHRFGQIRKRFVL 510
            ....        ||.:|..:.:::|..|.:....|:    :|.:.:...|   .:..::..:...
Worm   363 SVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFASMCRERISFRTRGTDT---SKLEKLMVKMGF 424

  Fly   511 FSLLYFAPTTAGVVAALCERYADSVPS--------CSTPDD-CLSPTPLSAWPALVRIFFQLVGG 566
            |..|:..|   .|:..:|:.|...:.:        |..... |..|||..|...:..:...|..|
Worm   425 FCALFILP---NVIELVCQCYKFMILTQWTRMTIDCKQQSGACHRPTPPQAEIYMTAVISSLATG 486

  Fly   567 TLTGLWVWSRKTCESYRN 584
            ....:||.|.||..:::|
Worm   487 FSCLMWVLSAKTVHAWKN 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	29/83 (35%)
		Frizzled	291..584	CDD:279827	79/314 (25%)
lin-17	NP_001021813.1	CRD_LIN_17	25..144	CDD:143563	29/84 (35%)
lin-17	NP_001021813.1	Frizzled	195..506	CDD:279827	80/316 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020