DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and Fzd9

DIOPT Version :9

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_034376.1 Gene:Fzd9 / 14371 MGIID:1313278 Length:592 Species:Mus musculus


Alignment Length:540 Identity:159/540 - (29%)
Similarity:239/540 - (44%) Gaps:114/540 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL--- 199
            |:|:..||::.||....||.|||...|:||..|..|:.||:.:||..|..|   ||  :||.   
Mouse    73 QLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRC---AP--IMEQFNF 132

  Fly   200 -WPSFLNCDGLP-QPEKHELCMQIPQEVAV---------------------PGGSPSGPPTTGSP 241
             ||..|:|..|| :.:.|.|||:.|:....                     ||.|..||   ||.
Mouse   133 GWPDSLDCARLPTRNDPHALCMEAPENATAGPTEPHKGLGMLPVAPRPARPPGDSAPGP---GSG 194

  Fly   242 GVEDHPQTYRFWKSGASPTSDLAGVLCPQNFSGSPFNPEECVPQCQR--DAFHTSSQKKTSETLI 304
            |..|:|:.:::.:...|                       |.|:|..  :.|.:...|..:...:
Mouse   195 GTCDNPEKFQYVEKSRS-----------------------CAPRCGPGVEVFWSRRDKDFALVWM 236

  Fly   305 LGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE--- 366
            ...||:||..|.|.:.||..||.||.|||||::||.:|||::|:.:|.|.|...|:...|.|   
Mouse   237 AVWSALCFFSTAFTVFTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGA 301

  Fly   367 ---LQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFH 428
               :|..|...||.|.      ::...|..:.::.||::..|.::|::.|||..||:|.....||
Mouse   302 LYVIQEGLENTGCTLV------FLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFH 360

  Fly   429 VLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSL 485
            :.||..|....|..|.|.||...||||:||.        .|||.:|....|:||..|.|....:|
Mouse   361 MAAWGLPALKTIVVLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLTGFVAL 425

  Fly   486 LSLQQQLQPTLAH-HRFGQIRKRFVLFSLLYFAPTTAGVVAALCERY---------------ADS 534
            ..:::.::....: .:..::..:..:||:||..|.|..:|..:.||.               |.:
Mouse   426 FHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAAT 490

  Fly   535 VP----SCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGASGTPTSS 595
            ||    .||.|...:....:    .:::||..||.|..:|:||||.||.::::           |
Mouse   491 VPGGRRDCSLPGGSVPTVAV----FMLKIFMSLVVGITSGVWVWSSKTFQTWQ-----------S 540

  Fly   596 LMNQSKAAGALPKKHLYTSG 615
            |..:..|||....|...|.|
Mouse   541 LCYRKMAAGRARAKACRTPG 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM <19..>122 CDD:223796
RRM_1 22..83 CDD:278504
CRD_FZ <138..224 CDD:295308 37/90 (41%)
Frizzled 291..584 CDD:279827 100/326 (31%)
Fzd9NP_034376.1 CRD_FZ9 36..162 CDD:143572 37/93 (40%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 59..173 37/104 (36%)
7tmF_FZD9 222..543 CDD:320164 102/341 (30%)
TM helix 1 231..256 CDD:320164 8/24 (33%)
TM helix 2 265..286 CDD:320164 10/20 (50%)
TM helix 3 315..341 CDD:320164 5/31 (16%)
TM helix 4 358..374 CDD:320164 6/15 (40%)
TM helix 5 396..426 CDD:320164 9/29 (31%)
TM helix 6 445..472 CDD:320164 8/26 (31%)
TM helix 7 504..529 CDD:320164 6/28 (21%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 533..538 2/4 (50%)
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 555..592 2/6 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831129
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D509772at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR11309
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.850

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