DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and Fzd9

DIOPT Version :10

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_034376.1 Gene:Fzd9 / 14371 MGIID:1313278 Length:592 Species:Mus musculus


Alignment Length:540 Identity:159/540 - (29%)
Similarity:239/540 - (44%) Gaps:114/540 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL--- 199
            |:|:..||::.||....||.|||...|:||..|..|:.||:.:||..|..|   ||  :||.   
Mouse    73 QLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRC---AP--IMEQFNF 132

  Fly   200 -WPSFLNCDGLP-QPEKHELCMQIPQEVAV---------------------PGGSPSGPPTTGSP 241
             ||..|:|..|| :.:.|.|||:.|:....                     ||.|..||   ||.
Mouse   133 GWPDSLDCARLPTRNDPHALCMEAPENATAGPTEPHKGLGMLPVAPRPARPPGDSAPGP---GSG 194

  Fly   242 GVEDHPQTYRFWKSGASPTSDLAGVLCPQNFSGSPFNPEECVPQCQR--DAFHTSSQKKTSETLI 304
            |..|:|:.:::.:...|                       |.|:|..  :.|.:...|..:...:
Mouse   195 GTCDNPEKFQYVEKSRS-----------------------CAPRCGPGVEVFWSRRDKDFALVWM 236

  Fly   305 LGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE--- 366
            ...||:||..|.|.:.||..||.||.|||||::||.:|||::|:.:|.|.|...|:...|.|   
Mouse   237 AVWSALCFFSTAFTVFTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGA 301

  Fly   367 ---LQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFH 428
               :|..|...||.|.      ::...|..:.::.||::..|.::|::.|||..||:|.....||
Mouse   302 LYVIQEGLENTGCTLV------FLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFH 360

  Fly   429 VLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSL 485
            :.||..|....|..|.|.||...||||:||.        .|||.:|....|:||..|.|....:|
Mouse   361 MAAWGLPALKTIVVLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLTGFVAL 425

  Fly   486 LSLQQQLQPTLAH-HRFGQIRKRFVLFSLLYFAPTTAGVVAALCERY---------------ADS 534
            ..:::.::....: .:..::..:..:||:||..|.|..:|..:.||.               |.:
Mouse   426 FHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAAT 490

  Fly   535 VP----SCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGASGTPTSS 595
            ||    .||.|...:....:    .:::||..||.|..:|:||||.||.::::           |
Mouse   491 VPGGRRDCSLPGGSVPTVAV----FMLKIFMSLVVGITSGVWVWSSKTFQTWQ-----------S 540

  Fly   596 LMNQSKAAGALPKKHLYTSG 615
            |..:..|||....|...|.|
Mouse   541 LCYRKMAAGRARAKACRTPG 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM_1 22..83 CDD:425453
CRD_FZ <138..224 CDD:470581 37/90 (41%)
7tmF_FZD3_insect 290..587 CDD:320159 100/330 (30%)
TM helix 1 299..324 CDD:320159 8/24 (33%)
TM helix 2 333..354 CDD:320159 10/20 (50%)
TM helix 3 383..409 CDD:320159 4/25 (16%)
TM helix 4 426..442 CDD:320159 6/15 (40%)
TM helix 5 469..493 CDD:320159 6/23 (26%)
TM helix 6 513..540 CDD:320159 11/45 (24%)
TM helix 7 548..573 CDD:320159 6/24 (25%)
Fzd9NP_034376.1 CRD_FZ9 36..162 CDD:143572 37/93 (40%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 59..173 37/104 (36%)
7tmF_FZD9 222..543 CDD:320164 102/341 (30%)
TM helix 1 231..256 CDD:320164 8/24 (33%)
TM helix 2 265..286 CDD:320164 10/20 (50%)
TM helix 3 315..341 CDD:320164 5/31 (16%)
TM helix 4 358..374 CDD:320164 6/15 (40%)
TM helix 5 396..426 CDD:320164 9/29 (31%)
TM helix 6 445..472 CDD:320164 8/26 (31%)
TM helix 7 504..529 CDD:320164 6/28 (21%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 533..538 2/4 (50%)
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 555..592 2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

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