| Sequence 1: | NP_001096859.1 | Gene: | fz3 / 31023 | FlyBaseID: | FBgn0027343 | Length: | 646 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_032084.2 | Gene: | Fzd8 / 14370 | MGIID: | 108460 | Length: | 685 | Species: | Mus musculus |
| Alignment Length: | 582 | Identity: | 155/582 - (26%) |
|---|---|---|---|
| Similarity: | 227/582 - (39%) | Gaps: | 154/582 - (26%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 129 DYKSDDEKG-QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENA 192
Fly 193 PPELME----LWPSFLNCDGLP-QPEKHELCMQI------------PQEVAVP------------ 228
Fly 229 ------------GGSPSG-------PPTTGS----PGVEDHPQTYRFWKSGASPTSDLAGVLCPQ 270
Fly 271 NFSGSPFNP----------EECVPQCQRDAFHTSSQKKTSETLI-LGL-SAVCFVLTLFALVTFW 323
Fly 324 AEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQ----------------------------- 359
Fly 360 -------AR-----MHDVELQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSH 412
Fly 413 KKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALV 469
Fly 470 LLLLGLYFTLRASRSLLS----LQQQLQPTLAHHRFGQIRKRFVLFSLLYFAPTTAGVVAALCER 530
Fly 531 YA----DSVPSCS-----TPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYR 583 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| fz3 | NP_001096859.1 | RRM | <19..>122 | CDD:223796 | |
| RRM_1 | 22..83 | CDD:278504 | |||
| CRD_FZ | <138..224 | CDD:295308 | 32/102 (31%) | ||
| Frizzled | 291..584 | CDD:279827 | 102/357 (29%) | ||
| Fzd8 | NP_032084.2 | CRD_FZ8 | 31..155 | CDD:143570 | 34/101 (34%) |
| Palmitate-binding groove | 71..78 | 2/6 (33%) | |||
| Wnt-binding | 95..100 | 1/4 (25%) | |||
| Wnt-binding | 147..152 | 3/4 (75%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 155..223 | 12/79 (15%) | |||
| 7tmF_FZD8 | 264..616 | CDD:320378 | 102/359 (28%) | ||
| TM helix 1 | 273..298 | CDD:320378 | 10/24 (42%) | ||
| TM helix 2 | 307..328 | CDD:320378 | 11/20 (55%) | ||
| TM helix 3 | 395..417 | CDD:320378 | 3/21 (14%) | ||
| TM helix 4 | 438..454 | CDD:320378 | 6/15 (40%) | ||
| TM helix 5 | 476..499 | CDD:320378 | 7/22 (32%) | ||
| TM helix 6 | 529..554 | CDD:320378 | 8/24 (33%) | ||
| TM helix 7 | 577..602 | CDD:320378 | 6/27 (22%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 606..611 | 3/4 (75%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 631..656 | ||||
| PDZ-binding | 683..685 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C167831134 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D509772at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.750 | |||||