DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and Fzd6

DIOPT Version :10

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_032082.3 Gene:Fzd6 / 14368 MGIID:108474 Length:709 Species:Mus musculus


Alignment Length:556 Identity:144/556 - (25%)
Similarity:219/556 - (39%) Gaps:112/556 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 EKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL 199
            |.|....|..|   .||......||.:..|.||..: ..|..|:.|||.:..:|     .:||:.
Mouse    57 EMGHFLHLANL---ECSPNIEMFLCQAFIPTCTEQI-HVVLPCRKLCEKIVSDC-----KKLMDT 112

  Fly   200 ----WPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPT 260
                ||..|.|:.||.      |     :..||              |..||.|.   .||....
Mouse   113 FGIRWPEELECNRLPH------C-----DDTVP--------------VTSHPHTE---LSGPQKK 149

  Fly   261 SDLA----GVLCPQNF--SGSP----FNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLT 315
            ||..    |..||::.  ||..    ...|:|.|.|. :.:..|.:...:::.|..:|..|...|
Mouse   150 SDQVPRDIGFWCPKHLRTSGDQGYRFLGIEQCAPPCP-NMYFKSDELDFAKSFIGIVSIFCLCAT 213

  Fly   316 LFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCL--L 378
            ||..:||..:..||.|||||:::..:||::.|:.|....:..|....:..:.:..|.....|  .
Mouse   214 LFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFVGFLLGNSTACNKADEKLELGDTVVLGSK 278

  Fly   379 TPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAAL 443
            ...|...::...:.::....||:|..:.::|::.:|||.||:|:::..||.:||..|....:..|
Mouse   279 NKACSVVFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGAPGFLTVMLL 343

  Fly   444 LLEKVRPSELTGMCY--------APGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHR 500
            .:.||....::|:|:        :..||.||..:.:.:||...|....||..::|.:|    |..
Mouse   344 AMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQ----HDG 404

  Fly   501 FGQIR-KRFVL----FSLLYFAP--TTAG-VVAALCERYADSVPSCSTPDDCLS---PTPLSAWP 554
            ..|.: |:|::    ||.||..|  |..| .|..|..|....:...|  |.|..   |.|..|.|
Mouse   405 RNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRITWEMTWFS--DHCHQYRIPCPYQANP 467

  Fly   555 A--------LVRIFFQLVGGTLTGLWVWSRKTCESY-----RNRLGASGTPTS------------ 594
            .        :::....|:.|.....||.|:|||..:     |||   ...|.|            
Mouse   468 KARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNR---KRDPISESRRVLQESCEF 529

  Fly   595 -----SLMNQSKAAGALPKKHLYTSGKSMLPTGGIT 625
                 |.:...|..||.....|....|||..:.|.|
Mouse   530 FLKHNSKVKHKKKHGAPGPHRLKVISKSMGTSTGAT 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM_1 22..83 CDD:425453
CRD_FZ <138..224 CDD:470581 24/89 (27%)
7tmF_FZD3_insect 290..587 CDD:320159 87/330 (26%)
TM helix 1 299..324 CDD:320159 8/24 (33%)
TM helix 2 333..354 CDD:320159 7/20 (35%)
TM helix 3 383..409 CDD:320159 3/25 (12%)
TM helix 4 426..442 CDD:320159 5/15 (33%)
TM helix 5 469..493 CDD:320159 6/23 (26%)
TM helix 6 513..540 CDD:320159 8/29 (28%)
TM helix 7 548..573 CDD:320159 5/32 (16%)
Fzd6NP_032082.3 CRD_FZ6 20..146 CDD:143559 33/125 (26%)
7tmF_FZD6 188..508 CDD:320160 84/325 (26%)
TM helix 1 197..222 CDD:320160 8/24 (33%)
TM helix 2 231..252 CDD:320160 7/20 (35%)
TM helix 3 283..309 CDD:320160 3/25 (12%)
TM helix 4 326..342 CDD:320160 5/15 (33%)
TM helix 5 364..393 CDD:320160 7/28 (25%)
TM helix 6 413..440 CDD:320160 9/26 (35%)
TM helix 7 469..494 CDD:320160 2/24 (8%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 498..503 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 583..709
Blue background indicates that the domain is not in the aligned region.

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