DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz3 and Fzd3

DIOPT Version :10

Sequence 1:NP_001096859.1 Gene:fz3 / 31023 FlyBaseID:FBgn0027343 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_067433.1 Gene:Fzd3 / 14365 MGIID:108476 Length:666 Species:Mus musculus


Alignment Length:522 Identity:124/522 - (23%)
Similarity:205/522 - (39%) Gaps:128/522 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 PLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL----WPSFL 204
            |::...|||..|..||:...|:|. :..|....|:.||:....||     .:|||:    ||..:
Mouse    67 PMVNLDCSRDFRPFLCALYAPICM-EYGRVTLPCRRLCQRAYSEC-----SKLMEMFGVPWPEDM 125

  Fly   205 NCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSP-GVEDHPQTYRFWKSGASPTSDLAGVLC 268
            .|...|..::     ..|:.|.:   :..|.||.|:| .|:   :.|.||              |
Mouse   126 ECSRFPDCDE-----PYPRLVDL---NLVGDPTEGAPVAVQ---RDYGFW--------------C 165

  Fly   269 PQNFSGSP------FNPEECVPQCQRDAFHTSSQKKTSETLILGL-SAVCFVLTLFALVTFWAEP 326
            |:.....|      .:..:|.|.|....|.  .::.:.....:|| |.:|...|||..:||..:.
Mouse   166 PRELKIDPDLGYSFLHVRDCSPPCPNMYFR--REELSFARYFIGLISIICLSATLFTFLTFLIDV 228

  Fly   327 TRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCLLTPP---------- 381
            |||.|||||::|..:||.:.|:.:....:..:              |..|..:.|          
Mouse   229 TRFRYPERPIIFYAVCYMMVSLIFFIGFLLED--------------RVACNASSPAQYKASTVTQ 279

  Fly   382 ------CLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPI 440
                  |...::...:.::..:.||:|..:.::|::..||.|||:||::.|||..||..|....|
Mouse   280 GSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTI 344

  Fly   441 AALLLEKVRPSELTGMCYAPGFVELPAL---------------VLLLLGLYFTLRASRSLLSLQQ 490
            ..|.:.|:....::|:|:. |..::.||               |.|||....:|...|..:.|::
Mouse   345 ILLAMNKIEGDNISGVCFV-GLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEK 408

  Fly   491 QLQPTLAHHRFGQIRKRFVLFSLLYFAPTTAGV-----------------VAALCERYADSVP-- 536
            :.|..|.     :...|..:||:||..|....:                 :...|..|....|  
Mouse   409 ENQDKLV-----KFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQ 468

  Fly   537 --SCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGASGTPTSSLMNQ 599
              ..|.||..|         .|::....|:.|..:..||.|:|||..:.:..  .|.....::|:
Mouse   469 VTQMSRPDLIL---------FLMKYLMALIVGIPSIFWVGSKKTCFEWASFF--HGRRKKEIVNE 522

  Fly   600 SK 601
            |:
Mouse   523 SR 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz3NP_001096859.1 RRM_1 22..83 CDD:425453
CRD_FZ <138..224 CDD:470581 23/83 (28%)
7tmF_FZD3_insect 290..587 CDD:320159 82/349 (23%)
TM helix 1 299..324 CDD:320159 9/25 (36%)
TM helix 2 333..354 CDD:320159 7/20 (35%)
TM helix 3 383..409 CDD:320159 3/25 (12%)
TM helix 4 426..442 CDD:320159 7/15 (47%)
TM helix 5 469..493 CDD:320159 7/23 (30%)
TM helix 6 513..540 CDD:320159 6/47 (13%)
TM helix 7 548..573 CDD:320159 3/24 (13%)
Fzd3NP_067433.1 CRD_FZ3 24..150 CDD:143558 25/96 (26%)
7tmF_FZD3 192..512 CDD:320161 82/352 (23%)
TM helix 1 201..226 CDD:320161 9/24 (38%)
TM helix 2 235..256 CDD:320161 7/20 (35%)
TM helix 3 287..313 CDD:320161 3/25 (12%)
TM helix 4 330..352 CDD:320161 8/21 (38%)
TM helix 5 366..391 CDD:320161 4/24 (17%)
TM helix 6 419..444 CDD:320161 6/24 (25%)
TM helix 7 473..498 CDD:320161 7/33 (21%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 502..507 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..666
Blue background indicates that the domain is not in the aligned region.

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