Protein Alignment fz3 and Corin

DIOPT Version :10

• Sequence 1: NP_001096859.1
• Gene: fz3 / 31023
• FlyBaseID: FBgn0027343
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_061506966.1
• Gene: Corin / 1277217
• VectorBaseID: AGAMI1_007116
• Length: 1432
• Species: Anopheles gambiae
• Alignment Length: 843
• Identity: 154/843 - (18%)
• Similarity: 237/843 - (28%)
• Gaps: 370/843 - (43%)

  Fly     3 GSDIAGIKLTSGPTSLRSRILVRNLPP--CTREELSFLCYPFGTILGSLVIDNHGFIQFATEREA 65
            |..:|||.:::|        .:|::||  ..|::.|              |.:..|.|.::....
Mosquito   613 GEGLAGIGVSTG--------TIRSVPPRVSMRQDSS--------------ISSDSFSQTSSPSYN 655

  Fly    66 TRAIEA--LNHSTFKSK------------------DILVSNASFRSLKANCCVYAPPKKKRMIAW 110
            ::.:||  |:|:....|                  |:..:.|..:|..      .|...:.::..
Mosquito   656 SKIMEAPLLSHAAKMPKVSKPIAKNLDEITKESPTDVNGTAAIIKSAS------TPASLQTIVRL 714

  Fly   111 SDADDVSIVERNEDEDDDDYKSDDEKGQIAKL----VPLIESGCSRRARFLLCSSLFPLCTPDVP 171
            |:..:||:              ..:|.||.|.    .|.:.||   |.:|.||..|
Mosquito   715 SNGSNVSL--------------QHKKFQILKARKNSNPYVTSG---RLKFRLCQIL--------- 753

  Fly   172 RPVAACKLLCETVRGECMENAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPP 236
              :.|..||..........||.|.:     .|:|              |.....|||...|....
Mosquito   754 --LNAVGLLAIAGGLAAYFNAYPTI-----KFVN--------------QTITRTAVPASQPGSSA 797

  Fly   237 TTGSPGVEDHPQTYRFWKSGASP---TSDLAGVLCPQNFSG--SPFNPEECVPQ----CQRDAFH 292
            ..||..|...|.:........||   ..|:||     .|.|  :| .|..|:|.    ||:
Mosquito   798 VGGSGAVSSVPASGSGQSVAGSPGRTALDVAG-----GFRGDRNP-APGVCLPVIVKFCQQ---- 852

  Fly   293 TSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPT---RFGYPERPV---LFLCL----CYNLFS 347
                           ..|.:..|:|        |.   .||.||..:   ||..|    ||.|..
Mosquito   853 ---------------HRVPYNYTVF--------PNYIGHFGQPEAQIEIDLFEALVDVQCYELVP 894

  Fly   348 VCYLERIVFHNQARMHDVELQWRLMRPGC----LLTPPCLASYITTSYLSLCAASWWLIFAL--- 405
            :......|                  |.|    ...|||.:  :.|..:..| :.::.:|.|
Mosquito   895 LFLCSLFV------------------PKCGNSGATVPPCKS--LCTETMRRC-SFFFDVFGLELP 938

  Fly   406 -----------------CFYLSSHKK-------------------------W------------- 415
                             |..::.:|:                         |
Mosquito   939 EYLRCSIFNDAVSDQEECVGMAEYKESIIRSRRPMACTGFLCDKRRCIPNDWKCDGHVDCQDQTD 1003

  Fly   416 -------SSEALEKRSGLF----HVLAWVPPLAPPIAALLLEKVRPSELTG-------------- 455
                   ..:|:....|..    ||....|..  |........:|.||..|
Mosquito  1004 EAHCDFCGDDAIHCGEGQCMSQKHVCDGTPNC--PYGQDERNCIRLSERNGDLGRGTLEVYKADL 1066

  Fly   456 MCYAPGFVE------LPALVLLLLGLYFTLRASRSLL--------------SLQQQLQP------ 494
            ..:||..|:      .|.::..||| |.::.:||:.:              |:.:..|.
Mosquito  1067 KQWAPACVKNWDPATSPTMICSLLG-YSSVNSSRTAMRGSNRTLVSTKDASSMWRMYQKKDVNLI 1130

  Fly   495 -----------------TLAHHRFGQIRKRFVLFSLLYFAPTTAGVVAALCERYADSVPSCSTPD 542
                             |.::...|::|.|      .|| ..|..:|..          |.|.|.
Mosquito  1131 KEFNSCDINSRYPVAELTCSNFECGKVRNR------KYF-KATKRIVGG----------STSNPG 1178

  Fly   543 DCLSPTPLSAWPALVRIF------FQLVGGTLTGLWVWSRKTCESYRNRLGASGTPTSSLMNQ-- 599
            |         ||.:..|.      |...|..:...||.:...|      :|.|  |||..|..
Mosquito  1179 D---------WPFIAAILGGPEEVFYCAGVLIADQWVLTASHC------IGNS--PTSHTMRNVN 1226

  Fly   600 --SKAAGALPKK-HLYTSGKSMLPTGGITPLY----------------AGISFHN--VPVYNP 641
              :...|...:: |.|...|..:.|....|:|                ..::||.  :||..|
Mosquito  1227 DWTIQLGITRRRSHTYYGQKVKVKTVIPHPMYNLHIPHDNDIALFQLATRVAFHEHLLPVCLP 1289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM_1	22..83	CDD:425453	14/82 (17%)
		CRD_FZ	<138..224	CDD:470581	20/89 (22%)
		7tmF_FZD3_insect	290..587	CDD:320159	69/442 (16%)
		TM helix 1	299..324	CDD:320159	3/24 (13%)
		TM helix 2	333..354	CDD:320159	7/27 (26%)
		TM helix 3	383..409	CDD:320159	5/45 (11%)
		TM helix 4	426..442	CDD:320159	4/19 (21%)
		TM helix 5	469..493	CDD:320159	7/37 (19%)
		TM helix 6	513..540	CDD:320159	5/26 (19%)
		TM helix 7	548..573	CDD:320159	5/30 (17%)
Corin	XP_061506966.1	None