DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and fzd4

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_002936589.1	Gene:	fzd4 / 100497693	XenbaseID:	XB-GENE-478210	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	140/489 - (28%)
Similarity:	222/489 - (45%)	Gaps:	79/489 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 DEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELME 198
            |.:.|:....|||:.|||.:.:|.|||...|:||..:..|:..|..:|.:|:..|    .|.|.|
Frog    60 DAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRC----EPVLKE 120

  Fly   199 L---WPSFLNCDGL-PQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASP 259
            .   ||..|||... ||.:.:.:||:.|.:..||..|    .|...|| ||        .:...|
Frog   121 FGFAWPESLNCSKFPPQNDHNHMCMEGPGDDEVPVHS----KTPVLPG-ED--------CNSFGP 172

  Fly   260 TSD-LAGVLCPQNFSGSPFNPEECVPQCQRDA-FHTSSQKKTSETLILGLSAVCFVLTLFALVTF 322
            .|| ...|....|          ||.:|..|: .::...|:.::..:...:::||:.|.|.::||
Frog   173 NSDQYTWVKRSMN----------CVLKCGYDSGLYSRLSKEFTDIWMAVWASLCFISTAFTVLTF 227

  Fly   323 WAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVE-------LQWRLMRPGCLLTP 380
            ..:.:||.|||||::||.:|||::|:.|:.|:....:....|.|       :|..|...||.:.
Frog   228 LIDSSRFCYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAII- 291

  Fly   381 PCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLL 445
                 ::...:..:.::.||:|..|.::|::..||..||:|..|..||:.||..|....|..|::
Frog   292 -----FLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIM 351

  Fly   446 EKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPT-LAHHRF 501
            ..|...||||:||.        .|||..|....|::|..|......:|..::..||.. ....:.
Frog   352 RLVDADELTGLCYVGNQNIDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKL 416

  Fly   502 GQIRKRFVLFSLLYFAPTTAGVVAALCE-------RYADSVPSCSTPDDCLSPTPLSAWPALVRI 559
            .::..:..:||:||..|.|..:.....|       ||        |.||.      :....::.|
Frog   417 ERLMVKIGVFSVLYTVPATCVIACYFYEISNWNVFRY--------TADDS------NMAVEMLNI 467

  Fly   560 FFQLVGGTLTGLWVWSRKTCESYR---NRLGASG 590
            |..|:.|..:|:|:||.||..:::   |||..||
Frog   468 FMSLLVGITSGMWIWSAKTLHTWQKCTNRLVNSG 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	32/89 (36%)
		Frizzled	291..584	CDD:279827	85/318 (27%)
fzd4	XP_002936589.1	CRD_FZ4	28..153	CDD:143557	33/96 (34%)
		7tmF_FZD4	195..495	CDD:320166	85/319 (27%)
		TM helix 1	204..229	CDD:320166	6/24 (25%)
		TM helix 2	238..259	CDD:320166	10/20 (50%)
		TM helix 3	289..315	CDD:320166	4/31 (13%)
		TM helix 4	332..348	CDD:320166	6/15 (40%)
		TM helix 5	370..399	CDD:320166	7/28 (25%)
		TM helix 6	419..446	CDD:320166	7/26 (27%)
		TM helix 7	456..481	CDD:320166	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920