DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz3 and fzd6

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001238809.2	Gene:	fzd6 / 100490861	XenbaseID:	XB-GENE-478813	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	513	Identity:	132/513 - (25%)
Similarity:	211/513 - (41%)	Gaps:	110/513 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 DDYKSDDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVA-ACKLLCETVRGECMEN 191
            :.|..|....::...:||:...||......||.:..|.||.  |:.:. .|:.|||.|..:|
Frog    66 EHYDQDIAALRMEPFLPLLNLHCSPEVHTFLCRAFVPECTE--PKHITMPCRSLCERVYSDC--- 125

  Fly   192 APPELME----LWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVED---HPQ- 248
              ..|:|    .||:.|.||.:......:         :..||.|..|        .|   ||:
Frog   126 --KNLIETFGITWPAELECDRMRDCNNSQ---------SKGGGGPDDP--------HDALRHPEQ 171

  Fly   249 ---TYRFWKSGASPTSDLAGVLCPQNF---SGSPF---NPEECVPQCQRDAFHTSSQKKT----S 300
               .::||              |||:.   .||.|   ..:.|.|.|....|     ||.    :
Frog   172 VHRDFKFW--------------CPQHLKTSQGSGFKFLGVDRCAPPCPNMYF-----KKVDMDFA 217

  Fly   301 ETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDV 365
            :..|..:|.:|..:|||.::||..:..||.|||||::|..:||::.|:.|:...:..|....::.
Frog   218 KYFIGVISIICLCVTLFTVLTFLIDVQRFRYPERPIIFYSVCYSMVSLMYVIGFLMGNSIVCNER 282

  Fly   366 ELQWRLMRPGCLLT-----PPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSG 425
            |..:   ..|..:.     ..|...::...:.::....||::..:.::|::.:|||.||:|::|.
Frog   283 EENF---ASGDTVVLGSQHKACTIIFMLLYFCTMAGTIWWVMLTITWFLAAGRKWSCEAIEQKSL 344

  Fly   426 LFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYAPG---------FVELPALVLLLLGLYFTLRA 481
            .||.:||..|....|..|.:.||....::|:|:. |         ||.||..:.:.:||...|..
Frog   345 WFHGVAWGIPGILTIILLAMNKVEGDNISGVCFV-GLYDQEVSIYFVLLPLCLCVFIGLSLLLAG 408

  Fly   482 SRSLLSLQQQLQPTLAH-HRFGQIRKRFVL----FSLLYFAPTTAGVVAALC----ERYADSVPS 537
            ..||.:::|.:|    | .|..|..|:|::    ||..|..|.   |:...|    :.|..|...
Frog   409 IISLNNVRQVIQ----HDERNQQKLKKFMIRIGVFSGTYLVPL---VILLGCYVYEQVYRSSWEM 466

  Fly   538 CSTPDDCLS---PTPLS----AWPAL----VRIFFQLVGGTLTGLWVWSRKTCESYRN 584
            ....|:|..   |.|..    |.|.|    .:....|:.|.....||.|:|||..:.|
Frog   467 TWVSDNCQDYHIPCPFQLKNPARPDLGLFITKYIMTLIVGISAIFWVGSKKTCSEWVN 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	23/90 (26%)
		Frizzled	291..584	CDD:279827	88/330 (27%)
fzd6	NP_001238809.2	CRD_FZ6	39..172	CDD:143559	32/129 (25%)
		7tmF_FZD6	207..527	CDD:320160	89/334 (27%)
		TM helix 1	217..241	CDD:320160	8/23 (35%)
		TM helix 2	250..271	CDD:320160	8/20 (40%)
		TM helix 3	302..324	CDD:320160	2/21 (10%)
		TM helix 4	345..361	CDD:320160	6/15 (40%)
		TM helix 5	383..406	CDD:320160	6/22 (27%)
		TM helix 6	437..459	CDD:320160	6/24 (25%)
		TM helix 7	488..513	CDD:320160	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920