DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz3 and fzd5

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_004917802.1	Gene:	fzd5 / 100488110	XenbaseID:	XB-GENE-479707	Length:	559	Species:	Xenopus tropicalis

Alignment Length:	493	Identity:	143/493 - (29%)
Similarity:	223/493 - (45%)	Gaps:	65/493 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 DYKSDDEKG-QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENA 192
            ::.:.||.| ::.:..||:...||...:|.|||...|:|.||..:|:..|:.:||..:..|   :
Frog    56 NHDTQDEAGMEVHQFWPLVVIQCSLDLKFFLCSMYTPICLPDYRKPLPPCRSVCERAKAGC---S 117

  Fly   193 PPELME----LWPSFLNCDGLPQ-PEKHELCMQI--PQEVAVPGGSPSGPPTTGSPGVEDHPQTY 250
            |  ||.    .||..:|||.||: .:...|||..  .:....|      |||        ||...
Frog   118 P--LMRKYGFAWPERMNCDRLPEHGDPDTLCMDYNWTETTTTP------PPT--------HPPKV 166

  Fly   251 RFWKSGASPTSDLAGVL-CPQNF------SGSPFNPEEC--VPQCQRDAF--HTSSQKKTSETLI 304
            :      :|:||..||. |.:.|      |...:|..:.  ||.|....|  :.:..:||..|..
Frog   167 K------TPSSDCDGVCKCREPFLSITRESHPLYNRIKTGQVPNCAMPCFQPYFTQDEKTFATFW 225

  Fly   305 LGL-SAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLER-IVFHNQARMHDVEL 367
            :|| |.:||:.|...:.||..:..||.|||||::||..||...|:.|:.| ||.|.....:...:
Frog   226 IGLWSILCFISTFTTVATFLIDMERFRYPERPIIFLSACYLFVSIGYIVRLIVGHENVACNKDHI 290

  Fly   368 QWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAW 432
            .:....|..     |...::...:..:.::.||:|....::|::..||.:||:...|..||:.||
Frog   291 HYETTGPAL-----CTVVFLLIYFFGMASSIWWVILTFTWFLAAGMKWGNEAIASYSQYFHMAAW 350

  Fly   433 VPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQ 489
            :.|....||.|.|..|....:.|:|:.        .|||..|.:|.|..|..|.|....||..::
Frog   351 LIPSVKSIAVLALSSVDGDPVAGICFVGNQNLDNLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIR 415

  Fly   490 QQL-QPTLAHHRFGQIRKRFVLFSLLYFAPTTAGVVAALCERYA----DSVPSCSTPDDCLSPTP 549
            ..: |......:..::..|..:||:||..|.|..|...:.|::.    :...:||.|.|.....|
Frog   416 SVIKQGGTKTDKLEKLMIRIGIFSVLYTVPATIVVACYIYEQHYREHWEKAHNCSCPGDKKRYRP 480

  Fly   550 LSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLG 587
            ..| ..:::.|..||.|..:|:|:||.||.||::...|
Frog   481 DYA-VFMLKYFMCLVVGITSGVWIWSGKTLESWKRFTG 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	30/92 (33%)
		Frizzled	291..584	CDD:279827	91/309 (29%)
fzd5	XP_004917802.1	CRD_FZ5	29..153	CDD:143569	33/101 (33%)
		7tmF_FZD5	212..517	CDD:320377	90/310 (29%)
		TM helix 1	221..246	CDD:320377	9/24 (38%)
		TM helix 2	255..276	CDD:320377	9/20 (45%)
		TM helix 3	301..327	CDD:320377	3/25 (12%)
		TM helix 4	344..360	CDD:320377	6/15 (40%)
		TM helix 5	382..411	CDD:320377	9/28 (32%)
		TM helix 6	431..458	CDD:320377	9/26 (35%)
		TM helix 7	478..503	CDD:320377	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920