DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and Fzd7

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001258114.1	Gene:	Fzd7 / 100360552	RGDID:	2321905	Length:	572	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	141/521 - (27%)
Similarity:	223/521 - (42%)	Gaps:	96/521 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 DDEKGQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELM 197
            :|...::.:..||::..||...||.|||...|:||. :.:.:..|:.|||..|..|     ..||
  Rat    77 EDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCRSLCERARQGC-----EALM 135

  Fly   198 E----LWPSFLNCDGLPQPEKHELCMQIPQEVA----VPGGSPSGPPTTGSPGVEDHPQTYRFWK 254
            .    .||..|.|:..|.....|:|  :.|..:    ..||||:..||  :|.:.|.|.|
  Rat   136 NKFGFQWPERLRCENFPVHGAGEIC--VGQNTSDGSGGAGGSPTAYPT--APYLPDPPFT----- 191

  Fly   255 SGASPTSDLAG-----VLCPQNFSGSPF------NPEECVPQCQ----RDAFHTSSQKKTSETLI 304
              |...||..|     ..||:.....|:      ...:|...|:    ....:...:::....|.
  Rat   192 --AMSPSDGRGRWSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLW 254

  Fly   305 LGL-SAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQA----RMHD 364
            :|: |.:|...|||.::|:..:..||.|||||::||..||.:.:|.::...:..::|    |..|
  Rat   255 VGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSD 319

  Fly   365 VELQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHV 429
            .  .:|.:..| .....|...::...:..:.::.||:|.:|.::|::..||..||:|..|..||:
  Rat   320 D--GYRTVAQG-TKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHL 381

  Fly   430 LAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSLL 486
            .||..|....|..|.:.:|....|:|:||.        .|||..|..|.|.:|..|.|....||.
  Rat   382 AAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLF 446

  Fly   487 SLQQQLQPTLAHH------RFGQIRKRFVLFSLLYFAPTTAGVVAA------------------- 526
            .::     |:..|      :..::..|..:||:||..|.|  :|.|
  Rat   447 RIR-----TIMKHDGTKTEKLEKLMVRIGVFSVLYTVPAT--IVLACYFYEQAFREHWERTWLLQ 504

  Fly   527 LCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYR---NRLGA 588
            .|:.||  || |  |....||........:::....::.|..||.|:||.||.:|:|   :||..
  Rat   505 TCKSYA--VP-C--PPGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSH 564

  Fly   589 S 589
            |
  Rat   565 S 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	27/89 (30%)
		Frizzled	291..584	CDD:279827	90/333 (27%)
Fzd7	NP_001258114.1	CRD_FZ7	45..169	CDD:143575	29/99 (29%)
		7tmF_FZD7	241..571	CDD:320374	93/340 (27%)
		TM helix 1	251..275	CDD:320374	8/23 (35%)
		TM helix 2	284..305	CDD:320374	8/20 (40%)
		TM helix 3	335..357	CDD:320374	3/21 (14%)
		TM helix 4	378..394	CDD:320374	6/15 (40%)
		TM helix 5	416..439	CDD:320374	8/22 (36%)
		TM helix 6	470..492	CDD:320374	8/23 (35%)
		TM helix 7	521..546	CDD:320374	3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750