DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz3 and fzd3

DIOPT Version :9

Sequence 1:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001123382.1	Gene:	fzd3 / 100038082	XenbaseID:	XB-GENE-484322	Length:	664	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	128/507 - (25%)
Similarity:	197/507 - (38%)	Gaps:	140/507 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMEL----WPSFL 204
            |::...|||..|..||:...|:|. :..|....|:.||:....||.     :|||:    ||..:
Frog    66 PMVNLECSRDFRPFLCALYAPVCM-EYGRVTLPCRKLCQRAYNECF-----KLMEMFGVPWPEEM 124

  Fly   205 NCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSP-GVEDHPQTYRFWKSGASPTSDLAGVLC 268
            .|...|..::     ..|:.|.:   |.||..|..:| .|:   :.|.||              |
Frog   125 ECSRFPDCDE-----PYPRMVDI---SLSGDVTEETPLAVQ---RDYGFW--------------C 164

  Fly   269 PQNFSGSP------FNPEECVPQCQRDAFHTSSQKKTSETLILG-LSAVCFVLTLFALVTFWAEP 326
            |:.....|      ....:|.|.|....|.  .::.:.....:| :|.||...|||..:||..:.
Frog   165 PRELKIDPDLGYSFLGVRDCSPPCPHMYFR--REELSFARYFIGVISIVCLSATLFTFLTFLIDV 227

  Fly   327 TRFGYPERPVLFLCLCYNLFSVCY-----LERIV------------------FHNQARMHDVELQ 368
            |||.|||||::|..:||.:.|:.:     ||..|                  .||:|
Frog   228 TRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDKVACNGANPSQYKAATVTQGSHNKA-------- 284

  Fly   369 WRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWV 433
                         |...::...:.::..:.||:|..:.::|::..||.|||:||::.|||..||.
Frog   285 -------------CTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWG 336

  Fly   434 PPLAPPIAALLLEKVRPSELTGMCYAPGFVELPAL---------------VLLLLGLYFTLRASR 483
            .|....|..|.:.|:....::|:|:. |..::.||               |.|||....:|...|
Frog   337 IPGTLTIILLAMNKIEGDNISGVCFV-GLYDVQALRYFVLAPLCLDVVVGVSLLLAGIISLNRVR 400

  Fly   484 SLLSLQQQLQPTLAHHRFGQIRKRFVLFSLLYFAPTTA------------GV-----VAALCERY 531
            ..:.|:::.|..|.     :...|..:||:||..|...            ||     |...|:.|
Frog   401 IEIPLEKENQDKLV-----KFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGVWETTWVQERCKEY 460

  Fly   532 ADSVP----SCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTC 579
            ....|    ..|.||..|         .|::....||.|..:..||.|:|||
Frog   461 HIPCPYKVTQTSRPDLIL---------FLMKYLMALVVGIPSVFWVGSKKTC 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	23/83 (28%)
		Frizzled	291..584	CDD:279827	89/349 (26%)
fzd3	NP_001123382.1	CRD_FZ3	23..149	CDD:143558	27/96 (28%)
		7tmF_FZD3	191..511	CDD:320161	89/351 (25%)
		TM helix 1	200..225	CDD:320161	9/24 (38%)
		TM helix 2	234..255	CDD:320161	7/20 (35%)
		TM helix 3	286..312	CDD:320161	3/25 (12%)
		TM helix 4	329..351	CDD:320161	8/21 (38%)
		TM helix 5	365..390	CDD:320161	4/24 (17%)
		TM helix 6	418..443	CDD:320161	6/24 (25%)
		TM helix 7	472..497	CDD:320161	8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920