DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5273 and ZP1

DIOPT Version :9

Sequence 1:	NP_569857.1	Gene:	CG5273 / 31021	FlyBaseID:	FBgn0040382	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_997224.2	Gene:	ZP1 / 22917	HGNCID:	13187	Length:	638	Species:	Homo sapiens

Alignment Length:	482	Identity:	97/482 - (20%)
Similarity:	144/482 - (29%)	Gaps:	182/482 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NSHADVAK---LSYPNYNSQPNR-------PMAAGSSGSPGS---APQPGWNVPQGPPPAYSASN 121
            |...|||:   |..|  ...|:|       |.|..|..:|.:   .|..| :..||...|:  .:
Human   122 NGRVDVAQDATLICP--KPDPSRTLDSQLAPPAMFSVSTPQTLSFLPTSG-HTSQGSGHAF--PS 181

  Fly   122 PAGGARPNMHEPPPAYHAPNYG-----AAPPNYGAATGSNVHQPQYSGVPAGATYYPAAGPGSGY 181
            |......::| |.||..:|..|     .|.|::|.....:|::..|.|..........|   ||:
Human   182 PLDPGHSSVH-PTPALPSPGPGPTLATLAQPHWGTLEHWDVNKRDYIGTHLSQEQCQVA---SGH 242

  Fly   182 SPNI----------PAGATYYPSAGHVPMGGGYHPAAAPPPGATYYQAGSALPPGAT-------- 228
            .|.|          .||.. |.:...||               .||        |.|
Human   243 LPCIVRRTSKEACQQAGCC-YDNTREVP---------------CYY--------GNTATVQCFRD 283

  Fly   229 -YYSAPPQQSSSGLGFGTGLLAGGLGGALLGHALTPSGGSSSSQPVAAAPAAGQDRIIIINNGVP 292
             |:.....|..:                 |.|.:|.:....:..|.:.:|....:..::..  .|
Human   284 GYFVLVVSQEMA-----------------LTHRITLANIHLAYAPTSCSPTQHTEAFVVFY--FP 329

  Fly   293 VNASDGTTVINA-----------AGVAAAPGAVPAAPVPSSNTTQDA-----------QQPAVPM 335
            :... |||:..|           :|:....|       |..:.|:|:           ....:|:
Human   330 LTHC-GTTMQVAGDQLIYENWLVSGIHIQKG-------PQGSITRDSTFQLHVRCVFNASDFLPI 386

  Fly   336 APMPFNPETSNMTAPDPAAPPPPGGIICVPTKVNETDPADST-------------------KMIE 381
            ....|.|       |.||....||     |.::......|.|                   ..:|
Human   387 QASIFPP-------PSPAPMTQPG-----PLRLELRIAKDETFSSYYGEDDYPIVRLLREPVHVE 439

  Fly   382 VEKI------------ACYPAPPPPAASAGEGPAPLAPMAAD----QPGSQQVQQVQQAQDVAAP 430
            |..:            .|:.||     ||.....|..|:.:|    :..|.:.|.|  |.|.|.|
Human   440 VRLLQRTDPNLVLLLHQCWGAP-----SANPFQQPQWPILSDGCPFKGDSYRTQMV--ALDGATP 497

  Fly   431 IQASVRSHT---------GGARALEGL 448
            .|:..:..|         |..|||.||
Human   498 FQSHYQRFTVATFALLDSGSQRALRGL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5273	NP_569857.1	DUF4813	165..385	CDD:292690	44/279 (16%)
ZP1	NP_997224.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..208		12/46 (26%)
		PD	234..275	CDD:197472	13/67 (19%)
		ZP	279..548	CDD:214579	53/292 (18%)
		Zona_pellucida	412..547	CDD:278526	27/120 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CXNA
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900