DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Igsf9

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	947	Identity:	202/947 - (21%)
Similarity:	315/947 - (33%)	Gaps:	321/947 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 PEIIVRPQDVKVKVGTGVV---ELQCIANARPLHELETLWLKDGLAVE---TAGVRHTLNDPWNR 319
            ||::    .|..:.|...|   :|...|...|||.:|  ||:.|..:.   ..|:.....||...
Mouse    24 PEVV----SVVGRAGESAVLGCDLLPPAGHPPLHVIE--WLRFGFLLPIFIQFGLYSPRIDPDYV 82

  Fly   320 TLALLQANSS---------HSGEYTCQV----------RLRSGGYPAVSASARLQILE-PPLFFT 364
            ....||..:|         ..|.|.|:|          ...:|.:..::.::..|..| |||...
Mouse    83 GRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLVLE 147

  Fly   365 PMRAETFGEFGGQVQLTCDVVGEPTPQVKW-FRNAESVDAHIESGRYTLNTDN-TLVIKKLILDD 427
            ....|.       |.|.|...|.|.|.|.| ||..:     :..|:..:...| ||.|:::....
Mouse   148 VKELEA-------VTLRCVARGSPQPYVTWKFRGQD-----LGKGQGQVQVQNGTLWIRRVERGS 200

  Fly   428 AAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRK 492
            |..:.|.|.:..|..:.:|.|.|                          ||
Mouse   201 AGDYTCQASSSEGSITHATQLLV--------------------------LG-------------- 225

  Fly   493 EFRFASAPIMELPPQNVTALDGKDATISCRAVGSP-NPNITWIYNETQLVDIS---SRVQILESG 553
                  .|::.:||.|.|....:|.:::|||...| |...:|..:...:..||   |||:||..|
Mouse   226 ------PPVIVVPPSNSTVNSSQDVSLACRAEAYPANLTYSWFQDGVNVFHISRLQSRVRILVDG 284

  Fly   554 DLLISNIRSVDAGLYICVRANEAGSV---KGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVS 615
            .|.:...:..|||.|.||.:|  |.:   ...|||:||...|:...|.:|.:..|:...::|.|.
Mouse   285 SLWLQATQPDDAGHYTCVPSN--GFLHPPSASAYLTVLYPAQVTVMPPETPLPTGMRGVIRCPVR 347

  Fly   616 SDPSVPYNIDWYREGQ-------------------------------SSTPISN----------- 638
            ::|.:.: :.|.::||                               |.||.::
Mouse   348 ANPPLLF-VTWTKDGQALQLDKFPGWSLGPEGSLIIALGNENALGEYSCTPYNSLGTAGPSPVTQ 411

  Fly   639 -----------------SQRIG-------------------------------VQADGQLEIQAV 655
                             .|.:|                               |.::..|.::.:
Mouse   412 VLLKAPPAFIDQPKEEYFQEVGRELLIPCSARGDPPPIVSWAKVGRGLQGQAQVDSNNSLVLRPL 476

  Fly   656 RASDVGSYACVVTSPGGNETRAARLSVI-ELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPI 719
            .....|.:.|..::.....|.:..:.|: ..|...:||.|..||    :..||||.|||||.
Mouse   477 TKEAQGRWECSASNAVARVTTSTNVYVLGTSPHVVTNVSVVPLP----KGANVSWEPGFDGG--- 534

  Fly   720 SKFIIQRREV--SELGPVPDPL-LNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVG--- 778
               .:||..|  :.|...||.. .:|::....:.|..  :|:..|:|...|||.|.|.|::|
Mouse   535 ---YLQRFSVWYTPLAKRPDRAHHDWVSLAVPIGATH--LLVPGLQAHAQYQFSVLAQNKLGSGP 594

  Fly   779 ---------EGSPSEPSNVVELPQEAPS--GPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGY 832
                     ||.|:.|:.....|.|.|.  .||.|.| :.|:...::..|.||  |...|::.||
Mouse   595 FSEIVLSIPEGLPTTPAAPGLPPTEIPPPLSPPRGLV-AVRTPRGVLLHWDPP--ELIPGRLDGY 656

  Fly   833 ILRYRLFGYNNVPWSY--QNITNEAQRNFLIQELITWKDYIVQ----------------IAAYNN 879
            ||..|   ..:..|..  |.:.. .:...|:..||  ||.:.:                :|..:.
Mouse   657 ILEGR---QGSQGWEILDQGVAG-TEIQLLVPGLI--KDVLYEFRLVAFADSYVSDPSNVANIST 715

  Fly   880 MGVGVYTEGSKIKTKEGVPEAPPTNV-----------KVEAINSTAARCRWTPPNPQQINGINQG 933
            .|:.||...:::      |...|..|           .|..:.|..|.|...
Mouse   716 SGLEVYPSRTQL------PGLLPQPVLAGVVGGVCFLGVAVLVSILAACLMN------------- 761

  Fly   934 YKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVAS 998
                  :||..    |...:|::..||.:..|..:..:                 .:.||.|
Mouse   762 ------RRRAA----RRHRKRLRQDPPLIFSPRGKSGS-----------------HSAPGSG--- 796

  Fly   999 SQVAVMTMDDVPDEVT--GLHFDDVSDRSVKVLWAPP 1033
                      .||.||  .|....|......:||..|
Mouse   797 ----------SPDSVTKFKLQGSPVPSLRQSLLWGEP 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	20/97 (21%)
		Ig	280..343	CDD:299845	19/84 (23%)
		IG_like	375..450	CDD:214653	21/76 (28%)
		Ig	378..447	CDD:143165	19/70 (27%)
		Ig	506..587	CDD:299845	30/87 (34%)
		IG_like	506..587	CDD:214653	30/87 (34%)
		I-set	592..682	CDD:254352	20/179 (11%)
		Ig	595..682	CDD:299845	19/176 (11%)
		FN3	686..789	CDD:238020	37/117 (32%)
		FN3	798..893	CDD:238020	26/112 (23%)
		FN3	901..1005	CDD:238020	16/114 (14%)
		fn3	1011..1094	CDD:278470	8/25 (32%)
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	21/83 (25%)
		Ig	136..223	CDD:386229	27/98 (28%)
		Ig_3	227..305	CDD:372822	27/77 (35%)
		Ig	341..404	CDD:386229	9/63 (14%)
		Ig	436..500	CDD:319273	5/63 (8%)
		FN3	508..599	CDD:238020	33/102 (32%)
		FN3	625..715	CDD:238020	23/98 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807		12/69 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000