DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and Robo2

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_038944599.1 Gene:Robo2 / 84409 RGDID:620167 Length:1625 Species:Rattus norvegicus


Alignment Length:1831 Identity:408/1831 - (22%)
Similarity:611/1831 - (33%) Gaps:607/1831 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDG----------------VPVGDFSSS 120
            ||...|||.  .|||:|....|.|.|.|.|.||..|.|||                :|.|   |.
  Rat    54 PRIVEHPSD--VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG---SL 113

  Fly   121 QFYRFHSTRRE--DAGSYQCIARNDAGSIFSEKSDVVVAYM--GIFENTTEGRLTVISGHPAIFD 181
            .|.|....||.  |.|:|.|:|||..|...|..:.:.||.:  ...:|.|:  :.|.:|.|||.:
  Rat   114 FFLRIVHGRRSKPDEGTYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD--VVVAAGEPAILE 176

  Fly   182 MPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAF 246
            ..|....|.|::.|:.:.                   :..||                |||    
  Rat   177 CQPPRGHPEPTIYWKKDK-------------------VRIDE----------------KEE---- 202

  Fly   247 VHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRH 311
             .:::.|...:                          |:|.|                       
  Rat   203 -RISIRGGKLM--------------------------ISNTR----------------------- 217

  Fly   312 TLNDPWNRTLALLQANSSHSGEYTC----QVRLRSGGYPAVSASARLQILEPPLFF-TPMRAETF 371
                            .|.:|.|||    .|..|.      |..|.|.:.|.|.|. .|:.....
  Rat   218 ----------------KSDAGMYTCVGTNMVGERD------SDPAELTVFERPTFLRRPINQVVL 260

  Fly   372 GEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAI 436
            .:  ...:..|.|.|:|.|.|:|.::    ||.:..|||.:..|.||.|||.|..|...:.|:|.
  Rat   261 ED--EPAEFRCQVQGDPQPTVRWKKD----DADLPRGRYDIKDDYTLRIKKAISADEGTYVCIAE 319

  Fly   437 NEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPI 501
            |..|:..||..|.|       ||:.:|.|:.: ||                              
  Rat   320 NRVGKVEASATLTV-------RVRPVAPPQFV-VR------------------------------ 346

  Fly   502 MELPPQNVTALDGKDATISCRAVGSPNPNITW---------IYNETQLVDISSRVQILESGDLLI 557
                |::.....|:..|..|...|:|.|.:.|         ..|:.|  ..:||..:..:|||.|
  Rat   347 ----PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ--QPNSRCSVSPTGDLTI 405

  Fly   558 SNIRSVDAGLYICVRANEAGSVKGEAYLSVL-VRTQ-----IIQPPVDTTVLLGLTATLQCKVSS 616
            :||:..|||.|||.....|||:..:|.|.|. |.|.     |:|.|::.|:.:..||.|:||.:.
  Rat   406 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPINQTLAVDGTALLKCKATG 470

  Fly   617 DPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLS 681
            :| :|. |.|.:||  .|.:....|..:|..|.|:|:.:|.||.|:|.||.||..|..:.:|.|.
  Rat   471 EP-LPV-ISWLKEG--FTFLGRDPRATIQDQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLD 531

  Fly   682 VIE-------------LPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQ--RREVSE 731
            |.|             ||.|||..:|   .:..:.|:.:||.||..|..|.|.:||:  .:.||.
  Rat   532 VTESGATISKNYDTNDLPGPPSKPQV---TDVTKNSVTLSWQPGTPGVLPASAYIIEAFSQSVSN 593

  Fly   732 LGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAP 796
                     :|.|..::|..  ....:..|:..|:|.|.|.|:|..|...||..|:.|.....:|
  Rat   594 ---------SWQTVANHVKT--TLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 647

  Fly   797 SGPPVGFVGSARSMSEIITQWQPPL-----------EEHRNGQ-ILGYILRYRLFGYNNVPWSYQ 849
            ....|......:.:.::..:...|:           ...|..| |.||.:.||..........:|
  Rat   648 PAQGVDHRQVQKELGDVTVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQASTVWQ 712

  Fly   850 NITNE--AQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAI-- 910
            |:..:  .:|:.::..|.....|.:::..|.|...|:.:|...|:|.|..|.|||.:|.|..:  
  Rat   713 NLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTIRTTEEAPSAPPQSVTVLTVGS 777

  Fly   911 -NSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWR-DIERRMKTVPPSLIDPLAEQTAIL 973
             |||:....|.||.....|||.|.|||  |   .:..|.| .|.   |||..::      ::.::
  Rat   778 HNSTSISVSWDPPPADHQNGIIQEYKI--W---CLGNETRFHIN---KTVDATI------RSVVI 828

  Fly   974 GGLEKFTEYNISVLCFTDPGDGVASSQ-----------VAVMTMDDVPDEVTGLHFDDVSDR--- 1024
            |||....:|.:.|...|..|.||.|..           |.....:.:.:::|     ||..:   
  Rat   829 GGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSITEQIT-----DVVKQPAF 888

  Fly  1025 ---------------SVKVLWAPPRASNGILTGYTVRYQVKD--------RPDTLK----SFNLT 1062
                           |:.:.|.  |.....|:.|.|.:|..|        ||..|.    |:...
  Rat   889 IAGIGGACWVILMGFSIWLYWR--RKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNTGDPSYPWL 951

  Fly  1063 ADD---TELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSV 1124
            ||.   |.|.||...:..:   ||..:.|        ...:..|.            .|:....:
  Rat   952 ADSWPATSLPVNNSNSGPN---EIGNFGR--------GDFKHNVN------------KNLAEHGI 993

  Fly  1125 VLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVVG 1189
            ..:|. |.:.|.:.....|.||..:..|..:       |....:.......|.|.         .
  Rat   994 KKEFL-GMERNKNDVLPPVPGQGDKTATMLS-------DGAIYSSIDFTTKTTYN---------S 1041

  Fly  1190 SSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPR------GYNISYK 1248
            ||:.::||             |: .|.:.:.:..:....:.|...:|..:.:      |:..|..
  Rat  1042 SSQITQAT-------------PY-ATTQILHSNSIHELAVDLPDPQWKSSVQQKSDLMGFAYSLP 1092

  Fly  1249 QLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVP 1313
            ...|....:.|:|                   ::.|.|         |.|..           :|
  Rat  1093 DQNKGNNALLYIP-------------------DYRLAE---------GLSNR-----------MP 1118

  Fly  1314 SYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLT 1378
            .....|....::.:::           .|:|.:.|.|.......:......|.  |.:|:.....
  Rat  1119 HNQSQDFSTTSSHNSS-----------ERSGSLSGGKGGKKKKTKNSSKAQKN--NGSTWANVPL 1170

  Fly  1379 ELKKYVVYHVQVLAYTRLG-------NGALS---TPPIRVQTF------------ED---TPGVP 1418
            ....     ||.|..|.||       ||..|   .||:.|||:            ||   ||.|.
  Rat  1171 PPPP-----VQPLPGTELGHYPAEQENGYDSDSWCPPLPVQTYLHQGMEDELEEDEDRVPTPPVR 1230

  Fly  1419 SNVSFPDVS---------------------------LT------MARIIWDV---------PVDP 1441
            ...|.|.:|                           ||      :|:..|.:         ||.|
  Rat  1231 GVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNTPPPQPPVPP 1295

  Fly  1442 NGKILAYQVTYTLNGSAMLNYSREFPPSD-----------RTFRATELLPGK---YYSFSCTAQT 1492
                |.|     .:|:.:.:...:.|..|           |..||.:..||.   ....|.|...
  Rat  1296 ----LGY-----ASGALISDLETDVPDEDADDEEEPLEIPRPLRALDQTPGSSMDNLDSSVTGSM 1351

  Fly  1493 RLGW----------------------------GKIATALV---------------------YTTN 1508
            ..||                            |..|.|||                     :|::
  Rat  1352 VNGWGSASDEDRNFSSHRSSVGSSSDGSIFASGSFAQALVAAADKAGFRLDGTSLTRTGKAFTSS 1416

  Fly  1509 NRERPQAP----SVPQISRSQIQAHQITFSWTPGRDGFAPLRYYTVEMRENEGRWQPLPERVDPS 1569
            .|:||.:|    |....:::|.|..:.|.....||....|     |.....||....||...||.
  Rat  1417 QRQRPTSPFSTDSNTSAAQNQSQRPRPTKKHKGGRMDPQP-----VLPHRREGMPDDLPPPPDPP 1476

  Fly  1570 LSSFTAVGLRPYM---TYQFRIQATNDLGPSAFSRESVIVRTLPAAPAVGVGGLKVVPITTTSVR 1631
                ...|||..:   .:...::::.:...|:..|:.       ||...........|..||   
  Rat  1477 ----PGQGLRQQIGLSQHSGNVESSTERKGSSLERQQ-------AANLEDTKSSLDCPAKTT--- 1527

  Fly  1632 VQWSALETALW 1642
            |:|.. :|..|
  Rat  1528 VEWQH-QTQDW 1537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 32/87 (37%)
Ig 280..344 CDD:409353 10/67 (15%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 3/8 (38%)
Ig 360..451 CDD:472250 30/91 (33%)
Ig strand B 378..382 CDD:409353 0/3 (0%)
Ig strand C 391..395 CDD:409353 1/3 (33%)
Ig strand E 416..420 CDD:409353 2/3 (67%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 29/93 (31%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 1/12 (8%)
Ig strand E 554..557 CDD:409353 2/2 (100%)
Ig strand F 567..572 CDD:409353 3/4 (75%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 33/94 (35%)
Ig strand B 608..612 CDD:409353 2/3 (67%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 31/104 (30%)
FN3 798..893 CDD:238020 19/108 (18%)
FN3 901..1005 CDD:238020 35/118 (30%)
FN3 <960..>1261 CDD:442628 59/350 (17%)
fn3 1317..1402 CDD:394996 16/91 (18%)
FN3 1415..1507 CDD:238020 31/196 (16%)
FN3 1513..1608 CDD:238020 21/101 (21%)
FN3 1583..>2011 CDD:442628 11/60 (18%)
Robo2XP_038944599.1 IgC_1_Robo 54..152 CDD:409490 36/102 (35%)
Ig strand A 54..58 CDD:409490 2/3 (67%)
Ig strand A' 61..66 CDD:409490 2/6 (33%)
Ig strand B 70..78 CDD:409490 2/7 (29%)
Ig strand C 84..89 CDD:409490 2/4 (50%)
Ig strand C' 92..94 CDD:409490 0/1 (0%)
Ig strand D 105..108 CDD:409490 0/2 (0%)
Ig strand E 111..117 CDD:409490 3/8 (38%)
Ig strand F 129..137 CDD:409490 4/7 (57%)
Ig strand G 140..152 CDD:409490 2/11 (18%)
Ig 159..244 CDD:472250 30/197 (15%)
Ig strand B 173..177 CDD:409353 2/3 (67%)
Ig strand C 187..191 CDD:409353 0/3 (0%)
Ig strand E 209..213 CDD:409353 0/29 (0%)
Ig strand F 223..228 CDD:409353 3/4 (75%)
Ig strand G 237..240 CDD:409353 1/2 (50%)
Ig 251..333 CDD:472250 28/87 (32%)
Ig strand B 265..269 CDD:409353 0/3 (0%)
Ig strand C 278..282 CDD:409353 1/3 (33%)
Ig strand E 299..303 CDD:409353 2/3 (67%)
Ig strand F 313..318 CDD:409353 1/4 (25%)
Ig strand G 326..329 CDD:409353 1/2 (50%)
IgI_4_Robo 342..439 CDD:409391 32/133 (24%)
Ig strand A 342..346 CDD:409391 0/4 (0%)
Ig strand A' 348..352 CDD:409391 0/3 (0%)
Ig strand B 358..366 CDD:409391 2/7 (29%)
Ig strand C 369..376 CDD:409391 2/6 (33%)
Ig strand C' 378..381 CDD:409391 0/2 (0%)
Ig strand D 394..399 CDD:409391 1/4 (25%)
Ig strand E 401..408 CDD:409391 4/6 (67%)
Ig strand F 414..423 CDD:409391 4/8 (50%)
Ig strand G 425..436 CDD:409391 4/10 (40%)
IgI_5_Robo 446..532 CDD:409544 33/89 (37%)
Ig strand A 446..449 CDD:409544 1/2 (50%)
Ig strand A' 453..456 CDD:409544 0/2 (0%)
Ig strand B 462..469 CDD:409544 4/6 (67%)
Ig strand C 475..480 CDD:409544 2/5 (40%)
Ig strand C' 482..484 CDD:409544 1/3 (33%)
Ig strand D 491..495 CDD:409544 1/3 (33%)
Ig strand E 498..503 CDD:409544 2/4 (50%)
FN3 <510..882 CDD:442628 104/404 (26%)
Ig strand F 511..519 CDD:409544 4/7 (57%)
Ig strand G 522..532 CDD:409544 3/9 (33%)
FN3 549..642 CDD:238020 32/106 (30%)

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