DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	669	Identity:	162/669 - (24%)
Similarity:	245/669 - (36%)	Gaps:	185/669 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 APEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNR-TLAL 323
            :|..:.:|:|:.|.:|. ...|.|...|   :.....|.|.|||:   |.:..| ..|:| .::.
Human    23 SPHFLQQPEDLVVLLGE-EARLPCALGA---YWGLVQWTKSGLAL---GGQRDL-PGWSRYWISG 79

  Fly   324 LQANSSH-----------SGEYTCQVR---LRSGGYPAVSASARLQILEPPLFFTPMRAETFGEF 374
            ..||..|           ...|.||..   ||       |..|:|.:|.||        |.....
Human    80 NAANGQHDLHIRPVELEDEASYECQATQAGLR-------SRPAQLHVLVPP--------EAPQVL 129

  Fly   375 GG---------QVQLTCDVVGE--PTPQVKWFRNAESVDAHIESGRYTL-------NTDNTLVIK 421
            ||         ...|||...|:  |||::.|||:...:|.  .:...||       :.::||.:.
Human   130 GGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDG--ATFHQTLLKEGTPGSVESTLTLT 192

  Fly   422 KLILDDAAMFQCLAINEA---GENSAST---------WLRVKTKTAKNRVKRL------AQPRIL 468
            ....||.|.|.|.|.::|   |.::|.|         .|.....|.:...|.:      |||.:.
Human   193 PFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 257

  Fly   469 RVRASHAG---LGS--------------------EKGSESGSSDRRKEFRFASAPIMELPPQNVT 510
            ..|.:..|   ||:                    |..:..||::|.........||::..|:.|:
Human   258 GYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVS 322

  Fly   511 ALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESG-DLLISNIRSVDAGLYICVRAN 574
            ...|:||:.||...|:|.|.:||...        ...|:|.|| .|.:.::...|||.|:| ||
Human   323 VDVGEDASFSCAWRGNPLPRVTWTRR--------GGAQVLGSGATLRLPSVGPEDAGDYVC-RA- 377

  Fly   575 EAG--SVKGEAYLSVLVRTQIIQPPVDTTV-----LLGLTATLQCKVSSDPSVPYNIDW-YREG- 630
            |||  .::|.|   ...|..:..|||.|.:     .|...|.|||.|.:.|: |..:.| :.||
Human   378 EAGLSGLRGGA---AEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPA-PDAVVWSWDEGF 438

  Fly   631 ----------QSSTPISNSQ-RIGVQADGQLEIQAVRASDVG-SYACVVTS---PGGNETRAARL 680
                      ..:.|...|: .:|......|.|...:.||.. |:.|...:   .||.:....|.
Human   439 LEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRR 503

  Fly   681 SVIELPFPPSNVKV-------------------------ERLPEPQQRSINVSWTPG-FDGNSPI 719
            .:  ||    .|::                         .:.........|:...|| .||:|.
Human   504 DL--LP----TVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRIPGSSDGSSS- 561

  Fly   720 SKFIIQRREVSELGPVPD--PLLNWITELSNVSADQRWILLENLKAATVYQFR-VSAVNRVGEGS 781
                 :..|..|.|...|  |:::  |:.|::..::...|.........|:.| ||....:||.
Human   562 -----RGPEEEETGSREDRGPIVH--TDHSDLVLEEEGTLETKDPTNGYYKVRGVSVSLSLGEA- 618

  Fly   782 PSEPSNVVELPQEAPSGPP 800
               |...:.||..:|.|||
Human   619 ---PGGGLFLPPPSPLGPP 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	23/90 (26%)
		Ig	280..343	CDD:299845	20/77 (26%)
		IG_like	375..450	CDD:214653	28/104 (27%)
		Ig	378..447	CDD:143165	25/89 (28%)
		Ig	506..587	CDD:299845	29/83 (35%)
		IG_like	506..587	CDD:214653	29/83 (35%)
		I-set	592..682	CDD:254352	27/111 (24%)
		Ig	595..682	CDD:299845	27/108 (25%)
		FN3	686..789	CDD:238020	23/131 (18%)
		FN3	798..893	CDD:238020	3/3 (100%)
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	27/103 (26%)
		IGc2	38..106	CDD:197706	19/75 (25%)
		I-set	126..224	CDD:254352	27/99 (27%)
		Ig2_KIRREL3-like	141..223	CDD:143236	25/83 (30%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	14/74 (19%)
		IG_like	234..308	CDD:214653	13/73 (18%)
		Ig	312..395	CDD:299845	32/95 (34%)
		I-set	317..395	CDD:254352	30/90 (33%)
		Ig	397..501	CDD:299845	26/104 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601		14/63 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810