Protein Alignment sdk and Musk

DIOPT Version :10

• Sequence 1: NP_001284756.1
• Gene: sdk / 31017
• FlyBaseID: FBgn0021764
• Length: 2265
• Species: Drosophila melanogaster
• Sequence 2: NP_112323.2
• Gene: Musk / 81725
• RGDID: 3211
• Length: 868
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 128/550 - (23%)
• Similarity: 206/550 - (37%)
• Gaps: 149/550 - (27%)

  Fly   348 VSASARLQILEPPLFFTPMRAETFGEFGGQV-QLTCDVVGEPTPQVKWFRNAESVDAHIESGRYT 411
            |:.|...::.:.|:..||:  ||......:| ...|.|...|.|::.|.||  .:...:...||:
  Rat    16 VAFSGTEKLPKAPVITTPL--ETVDALVEEVATFMCAVESYPQPEISWTRN--KILIKLFDTRYS 76

  Fly   412 LNTDNTLVIKKLILD-DAAMFQCLAINEAG---ENSASTWLRVKTKTAKNRVKRLAQPRILRVRA 472
            :..:..|:....:.| |..::.|.|.|..|   |:..:  |:||.|           |:|.|
  Rat    77 IRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGA--LQVKMK-----------PKITR--- 125

  Fly   473 SHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNE 537
                                            ||.||..::|..|.:.|..:|:|.|:::||..:
  Rat   126 --------------------------------PPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGD 158

  Fly   538 TQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAY-----LSVLVRTQIIQPP 597
            :.|.: :||:.:||||.|.|.|::..|||.|.||..|..|:    ||     |.|.|..:|::.|
  Rat   159 SALRE-NSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGT----AYSKLVKLEVEVFARILRAP 218

  Fly   598 VDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQ--SSTPISNSQRIGVQADGQLEIQAVRASDV 660
            ....|..|...||:|.....| || .|.|...|.  ||..|..:.:..| .|.:|::...:.
  Rat   219 ESHNVTFGSFVTLRCTAIGMP-VP-TISWIENGNAVSSGSIQENVKDRV-IDSRLQLFITKP--- 277

  Fly   661 GSYACVVTSPGGNE----TRAARLSVIE----------------------------LPFPPSNVK 693
            |.|.|:.|:..|.:    ..||.:|:.|                            |.|  .|..
  Rat   278 GLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKESKGYCAQYRGEVCDAVLVKDSLVF--FNTS 340

  Fly   694 VERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSEL------GPVPDPL---LNWITELSNV 749
            .....|.|:..|:.:|.. ....||:.:...:....:.|      |.:|.|:   ..:...:..:
  Rat   341 YPDPEEAQELLIHTAWNE-LKAVSPLCRPAAEALLCNHLFQECSSGVLPTPMPICREYCLAVKEL 404

  Fly   750 SADQRWILLENLKAATVYQFRVSAVNRVGEGS--PS---EPS-------------NVVELPQEAP 796
            ...:.|:.:|......:|:..:..: .|.|.|  ||   :|:             |:...|....
  Rat   405 FCAKEWLAMEGKTHRGLYRSGMHFL-PVPECSKLPSMHQDPTACTRLPYLDYKKENITTFPSITS 468

  Fly   797 SGPPVGF-----------VGSARSMSEIIT 815
            |.|.|..           |..|.||:.||:
  Rat   469 SKPSVDIPNLPASTSSFAVSPAYSMTVIIS 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig_3	72..142	CDD:464046
		Ig	280..344	CDD:409353
		Ig strand B	280..283	CDD:409353
		Ig strand C	292..298	CDD:409353
		Ig strand E	319..323	CDD:409353
		Ig strand F	333..338	CDD:409353
		Ig	360..451	CDD:472250	24/95 (25%)
		Ig strand B	378..382	CDD:409353	1/4 (25%)
		Ig strand C	391..395	CDD:409353	0/3 (0%)
		Ig strand E	416..420	CDD:409353	1/3 (33%)
		Ig strand F	430..435	CDD:409353	1/4 (25%)
		Ig strand G	443..446	CDD:409353	0/2 (0%)
		Ig	502..587	CDD:472250	33/89 (37%)
		Ig strand B	517..521	CDD:409353	1/3 (33%)
		Ig strand C	530..534	CDD:409353	0/3 (0%)
		Ig strand E	554..557	CDD:409353	1/2 (50%)
		Ig strand F	567..572	CDD:409353	2/4 (50%)
		Ig strand G	580..583	CDD:409353	0/2 (0%)
		Ig	592..682	CDD:472250	26/95 (27%)
		Ig strand B	608..612	CDD:409353	2/3 (67%)
		Ig strand C	623..627	CDD:409353	1/3 (33%)
		Ig strand E	648..652	CDD:409353	1/3 (33%)
		Ig strand F	662..667	CDD:409353	2/4 (50%)
		Ig strand G	675..678	CDD:409353	0/2 (0%)
		FN3	686..789	CDD:238020	22/129 (17%)
		FN3	798..893	CDD:238020	8/28 (29%)
		FN3	901..1005	CDD:238020
		FN3	<960..>1261	CDD:442628
		fn3	1317..1402	CDD:394996
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		FN3	1583..>2011	CDD:442628
Musk	NP_112323.2	IgI_1_MuSK	28..117	CDD:409562	24/94 (26%)
		Ig strand A	28..31	CDD:409562	1/2 (50%)
		Ig strand A'	35..39	CDD:409562	2/3 (67%)
		Ig strand B	45..52	CDD:409562	1/6 (17%)
		Ig strand C	58..63	CDD:409562	1/4 (25%)
		Ig strand C'	65..67	CDD:409562	0/1 (0%)
		Ig strand D	75..78	CDD:409562	1/2 (50%)
		Ig strand E	82..88	CDD:409562	1/5 (20%)
		Ig strand F	95..102	CDD:409562	1/6 (17%)
		Ig strand G	109..117	CDD:409562	2/9 (22%)
		IgI_2_MuSK	122..209	CDD:409560	35/126 (28%)
		Ig strand A	122..125	CDD:409560	1/2 (50%)
		Ig strand A'	129..131	CDD:409560	1/1 (100%)
		Ig strand B	137..145	CDD:409560	2/7 (29%)
		Ig strand C	151..156	CDD:409560	1/4 (25%)
		Ig strand C'	158..161	CDD:409560	0/2 (0%)
		Ig strand D	166..170	CDD:409560	1/3 (33%)
		Ig strand E	173..179	CDD:409560	3/5 (60%)
		Ig strand F	186..194	CDD:409560	4/7 (57%)
		Ig strand G	197..202	CDD:409560	3/8 (38%)
		Ig strand G'	204..209	CDD:409560	1/4 (25%)
		Ig	213..296	CDD:472250	24/88 (27%)
		Ig strand B	229..233	CDD:409353	2/3 (67%)
		Ig strand C	242..246	CDD:409353	1/3 (33%)
		Ig strand E	268..272	CDD:409353	1/3 (33%)
		Ig strand F	279..284	CDD:409353	2/4 (50%)
		Ig strand G	292..295	CDD:409353	0/2 (0%)
		CRD_TK_ROR_related	313..457	CDD:143578	22/147 (15%)
		PTKc_Musk	568..857	CDD:133181