Protein Alignment sdk and Robo4

DIOPT Version :10

• Sequence 1: NP_001284756.1
• Gene: sdk / 31017
• FlyBaseID: FBgn0021764
• Length: 2265
• Species: Drosophila melanogaster
• Sequence 2: XP_006510707.1
• Gene: Robo4 / 74144
• MGIID: 1921394
• Length: 1074
• Species: Mus musculus
• Alignment Length: 477
• Identity: 127/477 - (26%)
• Similarity: 189/477 - (39%)
• Gaps: 106/477 - (22%)

  Fly   498 SAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQ-ILESGDLLI---- 557
            |.|.:.:.||:........|.:.||:.|.|.|.|.|:.|...|...:..:. :|..|.||:
Mouse    40 SPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPS 104

  Fly   558 --------SNIRSVDAGLYICVRANEAG-SVKGEAYLSVLVRTQIIQ-PPVDTTVLLGLTATLQC 612
                    .||.|...|:|.|..:|..| :|...|.|||.|..:..| .|.||..::|.:..|:|
Mouse   105 VQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLEC 169

  Fly   613 KVSSDPSVPY---NIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGG-N 673
                .|...|   ::.|:::|:..  :....|..|..| .|.:.....:|.|:|.|:.|:..| .
Mouse   170 ----GPPWGYPKPSVSWWKDGKPL--VLQPGRRTVSGD-SLMVSRAEKNDSGTYMCMATNNAGQR 227

  Fly   674 ETRAARLSVIE-------LPFPPSNVKVERL----PEPQQ-----RSINVSWT---PGFDGNSPI 719
            |:||||:|:.|       |......:::|.:    |||.:     .|:.:||.   |.....|..
Mouse   228 ESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYT 292

  Fly   720 SKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATV--------YQFRVSAVNR 776
            :.|..||....:..|       | ||          :||..|::|.:        |:|:|    |
Mouse   293 ALFRTQRSPRDQGSP-------W-TE----------VLLRGLQSAKLGGLHWGQDYEFKV----R 335

  Fly   777 VGEGSPSEP-SNV--VELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRL 838
            ...|....| |||  :.||::.||.||.| |........:...|.||..|..||.|.||.:
Mouse   336 PSSGRARGPDSNVLLLRLPEQVPSAPPQG-VTLRSGNGSVFVSWAPPPAESHNGVIRGYQV---- 395

  Fly   839 FGYNNVPWSYQNITNEAQRNFLIQELITWK-------DYIVQIAAYNNMGVGVYTEGSKIKTKEG 896
                   ||..|.:..|....::.|....:       .|.||:||....|.|..:....:...||
Mouse   396 -------WSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLGEG 453

  Fly   897 VPEAPPTNVKVEAINSTAARCR 918
                     |..:|:||...||
Mouse   454 ---------KALSISSTPPPCR 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig_3	72..142	CDD:464046
		Ig	280..344	CDD:409353
		Ig strand B	280..283	CDD:409353
		Ig strand C	292..298	CDD:409353
		Ig strand E	319..323	CDD:409353
		Ig strand F	333..338	CDD:409353
		Ig	360..451	CDD:472250
		Ig strand B	378..382	CDD:409353
		Ig strand C	391..395	CDD:409353
		Ig strand E	416..420	CDD:409353
		Ig strand F	430..435	CDD:409353
		Ig strand G	443..446	CDD:409353
		Ig	502..587	CDD:472250	27/98 (28%)
		Ig strand B	517..521	CDD:409353	1/3 (33%)
		Ig strand C	530..534	CDD:409353	1/3 (33%)
		Ig strand E	554..557	CDD:409353	1/2 (50%)
		Ig strand F	567..572	CDD:409353	2/4 (50%)
		Ig strand G	580..583	CDD:409353	0/2 (0%)
		Ig	592..682	CDD:472250	26/94 (28%)
		Ig strand B	608..612	CDD:409353	1/3 (33%)
		Ig strand C	623..627	CDD:409353	0/3 (0%)
		Ig strand E	648..652	CDD:409353	1/3 (33%)
		Ig strand F	662..667	CDD:409353	2/4 (50%)
		Ig strand G	675..678	CDD:409353	1/2 (50%)
		FN3	686..789	CDD:238020	29/125 (23%)
		FN3	798..893	CDD:238020	25/101 (25%)
		FN3	901..1005	CDD:238020	6/18 (33%)
		FN3	<960..>1261	CDD:442628
		fn3	1317..1402	CDD:394996
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		FN3	1583..>2011	CDD:442628
Robo4	XP_006510707.1	Ig	42..144	CDD:472250	29/101 (29%)
		Ig strand B	59..63	CDD:409353	1/3 (33%)
		Ig strand C	72..76	CDD:409353	1/3 (33%)
		Ig strand E	96..100	CDD:409353	2/3 (67%)
		Ig strand F	122..127	CDD:409353	2/4 (50%)
		Ig strand G	136..139	CDD:409353	0/2 (0%)
		Ig	151..236	CDD:472250	26/91 (29%)
		Ig strand B	165..169	CDD:409353	1/3 (33%)
		Ig strand C	179..183	CDD:409353	0/3 (0%)
		Ig strand E	201..205	CDD:409353	2/4 (50%)
		Ig strand F	215..220	CDD:409353	2/4 (50%)
		Ig strand G	229..232	CDD:409353	1/2 (50%)
		FN3	<267..>446	CDD:442628	54/212 (25%)
		fn3	361..443	CDD:394996	25/93 (27%)