DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and USH2A

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:2616 Identity:551/2616 - (21%)
Similarity:906/2616 - (34%) Gaps:736/2616 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PKTTITATLAIEMPSQPKLASLLAVLVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHP 78
            |...:|.|....:|.:.  |:|.|.::          .:...:::.....||..|.:...:|...
Human  2912 PSREVTVTTLAGLPERG--ANLTASVL----------NHTAIDVRWAKPTVQDLQGEVEYYTLFW 2964

  Fly    79 SSSGSIVSEGSTKIL---QCHALGYPQP-TYRWL--------------------KDGVPVG---- 115
            ||:   .|..|.|||   ..|.:|:.:| |..|:                    .||.|.|    
Human  2965 SSA---TSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGMLPP 3026

  Fly   116 -------------------------DFSSSQFYRFHSTRREDAGSYQCIARN-DAGSIFSEKSDV 154
                                     ::|.....:.:.|.....||:  |.|: ...:|:..:.:|
Human  3027 EVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGMNVPGSF--ILRDLSPFTIYDIQVEV 3089

  Fly   155 VVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVM--WQSEDGP----LNYDIK----YA 209
            ...|..:..|.|:  :|.:...|:....|.|..|...|:.  |.|...|    |.||:.    |.
Human  3090 CTIYACVKSNGTQ--ITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYP 3152

  Fly   210 FTHANQLIILSADE--------------------------------NDRKGYRAKAINTQLGKEE 242
            .....:|:...:||                                |.:.|:|.       .:|:
Human  3153 CAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRC-------CEEK 3210

  Fly   243 SSAFVHLNVSG----------DP--------YIEVAPEIIVRPQDVKVKVGTGVVELQC------ 283
            ...|| ||.:|          .|        |..:.|..:..|.:...:|..|:.:..|      
Human  3211 YIPFV-LNSTGVCCGGRIQEAQPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYS 3274

  Fly   284 -----IANARPLHELETLWLKDGLAVETAGVRHTLND----------PWNRTLALLQAN------ 327
                 |..|..||        ||...:..|.:...||          .:||...:....      
Human  3275 TSGNQICCAGRLH--------DGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNM 3331

  Fly   328 ------SSHSGE-------------------------------------YTCQVRLRSGGYPAVS 349
                  |:.|||                                     |.|..::.:|  ..:.
Human  3332 SDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTG--MMMK 3394

  Fly   350 ASARLQILEPPLFFTPMRAETFGEFGGQVQLT-----CDVV-GEPTPQVKWFRNAESVDAHIESG 408
            .:...:||.|    ..|.|.   |..|:....     |.|: |......|     .|::....|.
Human  3395 ETKECRILCP----ASMEAT---EHCGRCDFNFTSHICTVIRGSHNSTGK-----ASIEEMCSSA 3447

  Fly   409 RYTLNTD--NTLVIKKLILDDAAMFQ--CLAINEAGENSASTWLRVKTK---------TAKNRVK 460
            ..|::|.  ||.....:.|.....::  ..|.|..| ...|..:|.:||         ....::.
Human  3448 EETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYG-RGLSKAVRARTKEDVPQGVSPPTWTKID 3511

  Fly   461 RLAQPRILRVRAS-------------HAGLGSEKGSESGSSDRR-----KEFRFASAPIMELPPQ 507
            .|....:|..|..             ..|:...:|:....||:.     :|:.:      :|...
Human  3512 NLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSY------QLKAC 3570

  Fly   508 NVTALDGKDATISCRAVGSPN----PNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGL- 567
            .|.........::....|.|.    |:||.:  ....:.:|..|....:|.:....||.|..|| 
Human  3571 TVAGCATSSKVVAATTQGVPESILPPSITAL--SAVALHLSWSVPEKSNGVIKEYQIRQVGKGLI 3633

  Fly   568 YICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQS 632
            :.........:|.|            :||..:.:..|....:..| .||:|.:...:....||..
Human  3634 HTDTTDRRQHTVTG------------LQPYTNYSFTLTACTSAGC-TSSEPFLGQTLQAAPEGVW 3685

  Fly   633 STP---ISNSQRI-----------GVQADGQLEIQA-----------------VRASDVGSYACV 666
            .||   |.||..:           |:.:..||....                 :..:...:|...
Human  3686 VTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLE 3750

  Fly   667 VTSPGGNETRAARLSVIELP-------FPPSNVKVERLPEPQQRSINVSW-TPGFDGNSPISKFI 723
            |.:.||:.  |:...:::.|       :||.|:.|     ....||.|:| .||.          
Human  3751 VKTGGGSS--ASDDYIVQTPMSTPEEIYPPYNITV-----IGPYSIFVAWIPPGI---------- 3798

  Fly   724 IQRREVSELGPVPDPLLN--WITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPS 786
                .:.|:....:.|||  .:|.|:......:..|||||...|.|:.|:.|..   .||....|
Human  3799 ----LIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQ---NGSCGVSS 3856

  Fly   787 NV-VELPQEAP---SGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNN---- 843
            .: |:.|:.||   :.|.:..:|||.    |..:|.||  |..||.|:.|.:..|..|...    
Human  3857 RMFVKTPEAAPMDLNSPVLKALGSAC----IEIKWMPP--EKPNGIIINYFIYRRPAGIEEESVL 3915

  Fly   844 VPWSYQNITNEAQRNFLIQ--ELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVK 906
            ..||      |....|:.:  .|..:..|..::.|.|:.| .|.:..|..:|.    ||||.:..
Human  3916 FVWS------EGALEFMDEGDTLRPFTLYEYRVRACNSKG-SVESLWSLTQTL----EAPPQDFP 3969

  Fly   907 VEAINSTAAR---CRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAE 968
            .....:|:|.   ..||  .|:..|||...|:: .:|.|..|..:..     .||....:...:.
Human  3970 APWAQATSAHSVLLNWT--KPESPNGIISHYRV-VYQERPDDPTFNS-----PTVHAFTVKGTSH 4026

  Fly   969 QTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSD-RSVKVLWAP 1032
            | |.|.|||.||.|.|.|:.....|: :.|....:.|::..|..:.....:...: |::.:.|:.
Human  4027 Q-AHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSE 4089

  Fly  1033 PRASNGILTGYTVRYQVKDRPDTLKSFNLTAD--------DTELTVNQLQATTHYWFEIVAWTRV 1089
            |..:||:                :|::|:.:|        :.:....:|...|.|...:.|.||.
Human  4090 PMRTNGV----------------IKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRA 4138

  Fly  1090 GSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKV-----EGQTAR 1149
            |........:.:...|  |.:..|..:.::::.||.|.::...:.|..|.:::|     ||:...
Human  4139 GCAHSAPQPLWTDEAP--PDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWG 4201

  Fly  1150 NMT-------WFTICEIN-DPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQAR 1206
            |.|       .||  |.| :.:......|||.|:||...::...|..|.:  ..:....:|:||.
Human  4202 NQTIQADEKIVFT--EYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHT--CSSWNVVRTLQAP 4262

  Fly  1207 PK--HPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNISYKQLVK----TPGTIKYVPRSVV 1265
            |:  .||. ::..:|:.|:|.:.|||.:|:.  |..:.|.:...:::.    .|.|..|..    
Human  4263 PEGLSPPV-ISYVSMNPQKLLISWIPPEQSN--GIIQSYRLQRNEMLYPFSFDPVTFNYTD---- 4320

  Fly  1266 IEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVPS-YGPLDVQANATSSTT 1329
                       :.|..::.|...:.||...|||....|:: .|.||.|| ..|.|:.  |.|:|.
Human  4321 -----------EELLPFSTYSYALQACTSGGCSTSKPTSI-TTLEAAPSEVSPPDLW--AVSATQ 4371

  Fly  1330 VVVQWGEVPRQHRNGQIDGYKVFY----AAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQV 1390
            :.|.|.  |...:||:|..|.|.|    :.|.:|..:|             ::.|:.|..|:..:
Human  4372 MNVCWS--PPTVQNGKITKYLVRYDNKESLAGQGLCLL-------------VSHLQPYSQYNFSL 4421

  Fly  1391 LAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDVSLT---MARIIWDVPVDPNGKILAYQ--- 1449
            :|.|  ..|..::......|.|   .:|.|:..|.:.:|   ...|.|..|.:|||:|.:|:   
Human  4422 VACT--NGGCTASVSKSAWTME---ALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRR 4481

  Fly  1450 ---VTYTLNGSAMLNYSREFPPSDRTFRATELLPGKYYSFSCTAQTRLGWGKIATALVYTTNNRE 1511
               :.||              ..:..:|...|.||..||::.||..  ..|.|.:.||   .:|.
Human  4482 DGTIVYT--------------GLETRYRDFTLTPGVEYSYTVTASN--SQGGILSPLV---KDRT 4527

  Fly  1512 RPQAPSVPQISRSQIQAHQ-ITFSWTPGRDGFAPLR------YYTVEMRENEGRWQPLPERVDP- 1568
            .|.|||..:..:.|.:..| |..:|.|      |:|      .||:.:||       |.||... 
Human  4528 SPSAPSGMEPPKLQARGPQEILVNWDP------PVRTNGDIINYTLFIRE-------LFERETKI 4579

  Fly  1569 ----------SLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAP---------- 1613
                      .:.|:....|:|:..|:.||||...||  ..|.:...::|...||          
Human  4580 IHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLG--CASSDWTFIQTPEIAPLMQPPPHLEV 4642

  Fly  1614 AVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRILYQQLSDFPTALQ---STPKTDVHG 1675
            .:..||.:    .|.|:          ||.|.....| ::||.:|.....|.|   |.|....:|
Human  4643 QMAPGGFQ----PTVSL----------LWTGPLQPNG-KVLYYELYRRQIATQPRKSNPVLIYNG 4692

  Fly  1676 INENSVVLSDLQQDRNYEIVVLPFNSQGPGPA------TPPAAVYVGEAVPTGEPRAVDAAPISS 1734
             :..|.:.|:|.....||..|...||.|..|:      |.||        |....||.....|||
Human  4693 -SSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPA--------PPEGLRAPTFHVISS 4748

  Fly  1735 TEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWEEEIEVVSATATSHSLVFLDKFTE 1799
            |:..:....|  ...||.:..|:::....:..:.:           :....||..:|..|..||.
Human  4749 TQAVVNISAP--GKPNGIVSLYRLFSSSAHGAETV-----------LSEGMATQQTLHGLQAFTN 4800

  Fly  1800 YRIQLLA---FNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVTWDPPKFLNGEILGY 1861
            |.|.:.|   ||....||.:   .::|.|..||.....:...:..::....|.||.|.||.|..|
Human  4801 YSIGVEACTCFNCCSKGPTA---ELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSY 4862

  Fly  1862 LVTYE-----------TTEENEKFSKQVKQKVSNTTLRVQNLEEEVTYTFTVRAQTSVDYGPGIS 1915
            .:.:.           |..:.|.....:.||.|     :..|:...||...|.|...|  |...|
Human  4863 ELQFHVACPPDSALPCTPSQIETKYTGLGQKAS-----LGGLQPYTTYKLRVVAHNEV--GSTAS 4920

  Fly  1916 ENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSR--WTKIEQTR 1978
            |.::...|...|.......:...||.|.::|    |....:.|.|.|....|..|  ::.::.| 
Human  4921 EWISFTTQKELPQYRAPFSVDSNLSVVCVNW----SDTFLLNGQLKEYVLTDGGRRVYSGLDTT- 4980

  Fly  1979 KGMMQDFTVSYHILMPSTA---YTFRVIAYNRYG-ISFPVYSKDS-------ILTPSKLHLEYGY 2032
                        :.:|.||   :.|:||.....| :..|:...|:       :.||.|  .:...
Human  4981 ------------LYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGK--KKGSR 5031

  Fly  2033 LQHKPFYRQTWFMVSLAATSIVIIVMVIAVLCVKSKSYK--YKQEAQKTLEESMAMSIDERQELA 2095
            .:...||.:.||:|.:|...::::.:.:: |.::.|.:|  |.:|....:.....||       .
Human  5032 SKSTEFYSELWFIVLMAMLGLILLAIFLS-LILQRKIHKEPYIRERPPLVPLQKRMS-------P 5088

  Fly  2096 LELYRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGV-HLG----KSPPRPSPASVAYHSD 2155
            |.:|                                 |||. |:|    |.|...:|.|:..:..
Human  5089 LNVY---------------------------------PPGENHMGLADTKIPRSGTPVSIRSNRS 5120

  Fly  2156 EESLKCYDENPDDSSVTEKPSEVSSSEASQHSESENESVRSDP---HSFVNH----YANVNDSLR 2213
            ...|:...:|  .:|:|.....:..| .||..:.:::.|..|.   .:.:.|    |.:..|.: 
Human  5121 ACVLRIPSQN--QTSLTYSQGSLHRS-VSQLMDIQDKKVLMDNSLWEAIMGHNSGLYVDEEDLM- 5181

  Fly  2214 QSWKKTKPVRNYSSYT 2229
                  ..::::||.|
Human  5182 ------NAIKDFSSVT 5191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845 25/139 (18%)
I-set 72..150 CDD:254352 24/131 (18%)
Ig 172..245 CDD:299845 19/114 (17%)
IG_like 280..356 CDD:214653 19/145 (13%)
Ig 280..343 CDD:299845 18/132 (14%)
IG_like 375..450 CDD:214653 16/84 (19%)
Ig 378..447 CDD:143165 15/78 (19%)
Ig 506..587 CDD:299845 16/85 (19%)
IG_like 506..587 CDD:214653 16/85 (19%)
I-set 592..682 CDD:254352 22/120 (18%)
Ig 595..682 CDD:299845 22/117 (19%)
FN3 686..789 CDD:238020 29/113 (26%)
FN3 798..893 CDD:238020 26/100 (26%)
FN3 901..1005 CDD:238020 29/106 (27%)
fn3 1011..1094 CDD:278470 15/91 (16%)
FN3 1108..1202 CDD:238020 24/106 (23%)
FN3 1210..1308 CDD:238020 22/101 (22%)
fn3 1317..1402 CDD:278470 23/88 (26%)
FN3 1415..1507 CDD:238020 26/100 (26%)
FN3 1513..1608 CDD:238020 29/112 (26%)
fn3 1617..1708 CDD:278470 26/99 (26%)
FN3 1722..1823 CDD:238020 23/103 (22%)
FN3 1828..1920 CDD:238020 24/102 (24%)
FN3 1927..2016 CDD:238020 20/94 (21%)
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
fn3 1150..1227 CDD:394996
FN3 1242..1357 CDD:238020
FN3 1368..1451 CDD:214495
LamG 1519..1678 CDD:238058
LamG 1716..1868 CDD:238058
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020 2/7 (29%)
FN3 2925..3015 CDD:238020 20/104 (19%)
FN3 3026..>3087 CDD:238020 7/62 (11%)
FN3 <3449..3494 CDD:238020 10/45 (22%)
FN3 3503..3586 CDD:238020 10/88 (11%)
FN3 3590..3676 CDD:238020 21/100 (21%)
FN3 3680..3767 CDD:238020 15/88 (17%)
fn3 3777..3856 CDD:394996 27/100 (27%)
FN3 3866..3960 CDD:238020 28/106 (26%)
FN3 3964..4057 CDD:238020 29/102 (28%)
fn3 4161..4247 CDD:394996 21/87 (24%)
FN3 4268..4351 CDD:238020 22/101 (22%)
fn3 4357..4428 CDD:394996 23/89 (26%)
FN3 4444..4516 CDD:238020 22/87 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541 8/25 (32%)
FN3 4529..4627 CDD:238020 29/112 (26%)
FN3 4636..4730 CDD:238020 26/109 (24%)
FN3 4826..4927 CDD:238020 25/107 (23%)
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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