DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	82/366 - (22%)
Similarity:	143/366 - (39%)	Gaps:	66/366 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 GGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEA 439
            |..|:|.|.|....:.:|.|....:|....:.:...|.|...::...|   .|......|.||..
  Fly    66 GRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDK---HDKHRTWFLHINNV 127

  Fly   440 GENSASTWL-RVKTKTAKNR---VKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAP 500
            .|.....:: ::.|.|||.:   ||.:..|.|                    .|
  Fly   128 QEEDRGRYMCQINTVTAKTQYGFVKVVVPPNI--------------------DD----------- 161

  Fly   501 IMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQI--LESGDLLISNIRSV 563
              .|...::...:|.:.|:.|:|.|||.|.|.|..::...:.|:..:::  ||:..|.:..|..:
  Fly   162 --ALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRL 224

  Fly   564 DAGLYICVRANEA-GSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDP-SVPYNIDW 626
            ..|.|:|:.:|.. .||.....:||.....:..|.....:.:|...||:|.:.::| |:.|   |
  Fly   225 HMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNY---W 286

  Fly   627 YREGQSSTPISNSQRI-------GVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIE 684
            .||.......|:..:.       ..:|..:|.|..|::||.|:|.||..:|.|:.....:|.:..
  Fly   287 TRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSS 351

  Fly   685 LPF---PPSNVKVERLPEPQQRSINVSWTPGFDG--NSPIS 720
            .|.   ||:...:       :|:...:.....||  |:|::
  Fly   352 PPTTQPPPTTTTL-------RRTTTTAAEIALDGYINTPLN 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653
		Ig	280..343	CDD:299845
		IG_like	375..450	CDD:214653	16/75 (21%)
		Ig	378..447	CDD:143165	15/68 (22%)
		Ig	506..587	CDD:299845	21/83 (25%)
		IG_like	506..587	CDD:214653	21/83 (25%)
		I-set	592..682	CDD:254352	25/97 (26%)
		Ig	595..682	CDD:299845	25/94 (27%)
		FN3	686..789	CDD:238020	8/40 (20%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/91 (24%)
		Ig	69..139	CDD:143165	15/72 (21%)
		IG_like	165..249	CDD:214653	21/83 (25%)
		IGc2	172..237	CDD:197706	19/64 (30%)
		IG_like	267..348	CDD:214653	23/83 (28%)
		Ig	270..339	CDD:299845	21/71 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810