DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and ROBO3

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_071765.2 Gene:ROBO3 / 64221 HGNCID:13433 Length:1386 Species:Homo sapiens


Alignment Length:1086 Identity:235/1086 - (21%)
Similarity:371/1086 - (34%) Gaps:312/1086 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDF------------SSSQFYR 124
            ||....|..  .:||.|....|.|.|.|.|:|...|.|:|..|...            |.:.|:.
Human    64 PRIVEQPPD--LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP 126

  Fly   125 --FHSTR-REDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIE 186
              .|..| |.|.|.|.|:|||..|:..|..:.:.||.:......:.|.:.|..|.||:.:..|..
Human   127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPR 191

  Fly   187 SIPVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNV 251
            ..|.|||.|:.:...|                                     |||..   .:.:
Human   192 GHPEPSVSWRKDGARL-------------------------------------KEEEG---RITI 216

  Fly   252 SGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDP 316
            .|...:                                                   :.|||   
Human   217 RGGKLM---------------------------------------------------MSHTL--- 227

  Fly   317 WNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFF-TPMRAETFGEFGGQVQL 380
                       .|.:|.|.|.....:|  ...||:|.:.:||.|.|. .|:......:  ..|..
Human   228 -----------KSDAGMYVCVASNMAG--ERESAAAEVMVLERPSFLRRPVNQVVLAD--APVTF 277

  Fly   381 TCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSAS 445
            .|:|.|:|.|:::|.:.    |..:.:|||.:.:|::|.|..:..:|...:.|:|.|..|...||
Human   278 LCEVKGDPPPRLRWRKE----DGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS 338

  Fly   446 TWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVT 510
                                                ||.|                :.:|||.||
Human   339 ------------------------------------GSLS----------------VHVPPQLVT 351

  Fly   511 ------ALDGKDATISCRAVGSPNPNITW-------IYNETQLVDISSRVQILESGDLLISNIRS 562
                  |..|:.....|...|:|.|.|.|       :...:|.:..:.|..:...|.|.|:.::.
Human   352 QPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQR 416

  Fly   563 VDAGLYICVRANEAGSVKGEAYLSVL------VRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVP 621
            .|||.|:|...:.|||:..:|.|.:.      :...|:|.|.:.|::||.:..|.|:|:.:|.. 
Human   417 GDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP- 480

  Fly   622 YNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIE-- 684
             ::.|.::||...  .:..:....|:|.|.|..|:..|:|.|:||..|..|..|.:..|.:.|  
Human   481 -SVRWKKDGQWLQ--GDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDW 542

  Fly   685 --LPFPPSNVKVERLPEPQ---------------QRSINVSWTPGFDGNSPISKFIIQRREVSEL 732
              .|.||:        ||.               :.||.::|.|.....:.::.::|:...    
Human   543 GVSPDPPT--------EPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFS---- 595

  Fly   733 GPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPS 797
               |.....|.|....|..:...:  ..|:..|:|.|.|.||...|...||..|..|.....:||
Human   596 ---PAAGNTWRTVADGVQLETHTV--SGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPS 655

  Fly   798 GPPVGFVGSARSMSEIITQWQPPLE-EHRNGQ-----------ILGYILRYRLFGYNNVPWSYQN 850
            .|........:.::|:..:.|.|:. ..|..|           :.|:.:.:|:.|.....|:..:
Human   656 RPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLD 720

  Fly   851 ITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVE--AINST 913
            :.:.:|::.:::.|.......:::.|....|:|..:........|..|..||..|.|.  ...::
Human   721 LQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNS 785

  Fly   914 AARCRWTPPNPQQINGINQGYKI---------------QAWQRRLIDGEWRDIERRMKTVPPSLI 963
            :....|.||.|.|.||:...|:|               ..|.|                      
Human   786 SITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWAR---------------------- 828

  Fly   964 DPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFD-DVSDRSVK 1027
                  :|:|.||.....|...|...|..|.||.|:.|.|. :...||...||... .::.|..:
Human   829 ------SAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQ-LPSPPDLEPGLEVGAGLAVRLAR 886

  Fly  1028 VLWAPP------RASNGILTG-----YTVRYQVKDRPDTLKSFNLT 1062
            ||..|.      .|...:|.|     |..|.|.|:......||..|
Human   887 VLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYT 932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 26/84 (31%)
Ig 280..344 CDD:409353 7/63 (11%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 24/91 (26%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 28/97 (29%)
Ig strand B 517..521 CDD:409353 0/3 (0%)
Ig strand C 530..534 CDD:409353 2/10 (20%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 27/89 (30%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 0/3 (0%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 25/117 (21%)
FN3 798..893 CDD:238020 15/106 (14%)
FN3 901..1005 CDD:238020 28/120 (23%)
FN3 <960..>1261 CDD:442628 31/115 (27%)
fn3 1317..1402 CDD:394996
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
FN3 1583..>2011 CDD:442628
ROBO3NP_071765.2 Ig 64..162 CDD:472250 30/99 (30%)
Ig strand B 81..85 CDD:409353 1/3 (33%)
Ig strand C 94..98 CDD:409353 0/3 (0%)
Ig strand E 121..125 CDD:409353 0/3 (0%)
Ig strand F 140..145 CDD:409353 2/4 (50%)
Ig strand G 154..157 CDD:409353 1/2 (50%)
Ig 169..254 CDD:472250 27/191 (14%)
Ig strand B 183..187 CDD:409353 1/3 (33%)
Ig strand C 197..201 CDD:409353 2/3 (67%)
Ig strand E 219..223 CDD:409353 0/54 (0%)
Ig strand F 233..238 CDD:409353 2/4 (50%)
Ig strand G 247..250 CDD:409353 2/2 (100%)
Ig 261..343 CDD:472250 25/139 (18%)
Ig strand B 275..279 CDD:409353 1/3 (33%)
Ig strand C 288..292 CDD:409353 0/3 (0%)
Ig strand E 309..313 CDD:409353 1/3 (33%)
Ig strand F 323..328 CDD:409353 1/4 (25%)
Ig strand G 336..339 CDD:409353 2/38 (5%)
Ig 348..445 CDD:472250 26/96 (27%)
Ig strand B 364..368 CDD:409353 0/3 (0%)
Ig strand C 377..381 CDD:409353 1/3 (33%)
Ig strand E 407..411 CDD:409353 2/3 (67%)
Ig strand F 421..426 CDD:409353 2/4 (50%)
Ig strand G 434..437 CDD:409353 0/2 (0%)
Ig 452..536 CDD:472250 26/87 (30%)
Ig strand B 468..472 CDD:409353 1/3 (33%)
Ig strand C 481..485 CDD:409353 0/3 (0%)
Ig strand E 504..508 CDD:409353 2/3 (67%)
FN3 <518..>809 CDD:442628 65/307 (21%)
Ig strand F 518..523 CDD:409353 2/4 (50%)
Ig strand G 531..534 CDD:409353 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..563 5/29 (17%)
FN3 556..649 CDD:238020 21/101 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..662 7/22 (32%)
FN3 770..863 CDD:238020 27/120 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 965..989
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1310
PRK12323 <1126..1325 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1386
Blue background indicates that the domain is not in the aligned region.

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