DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and ROBO2

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens


Alignment Length:1792 Identity:402/1792 - (22%)
Similarity:590/1792 - (32%) Gaps:649/1792 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDG----------------VPVGDFSSS 120
            ||...|||.  .|||:|....|.|.|.|.|.||..|.|||                :|.|   |.
Human    54 PRIVEHPSD--VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG---SL 113

  Fly   121 QFYRFHSTRRE--DAGSYQCIARNDAGSIFSEKSDVVVAYM--GIFENTTEGRLTVISGHPAIFD 181
            .|.|....||.  |.|||.|:|||..|...|..:.:.||.:  ...:|.|:  :.|.:|.|||.:
Human   114 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD--VVVAAGEPAILE 176

  Fly   182 MPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAF 246
            ..|....|.|::.|:.:.                   :..|:                |||    
Human   177 CQPPRGHPEPTIYWKKDK-------------------VRIDD----------------KEE---- 202

  Fly   247 VHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRH 311
             .:::.|...:                          |:|.|                       
Human   203 -RISIRGGKLM--------------------------ISNTR----------------------- 217

  Fly   312 TLNDPWNRTLALLQANSSHSGEYTC----QVRLRSGGYPAVSASARLQILEPPLFF-TPMRAETF 371
                            .|.:|.|||    .|..|.      |..|.|.:.|.|.|. .|:.....
Human   218 ----------------KSDAGMYTCVGTNMVGERD------SDPAELTVFERPTFLRRPINQVVL 260

  Fly   372 GEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAI 436
            .|  ..|:..|.|.|:|.|.|:|.::    ||.:..|||.:..|.||.|||.:..|...:.|:|.
Human   261 EE--EAVEFRCQVQGDPQPTVRWKKD----DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAE 319

  Fly   437 NEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPI 501
            |..|:..||..|.|       |.:.:|.|:.: ||                              
Human   320 NRVGKMEASATLTV-------RARPVAPPQFV-VR------------------------------ 346

  Fly   502 MELPPQNVTALDGKDATISCRAVGSPNPNITW---------IYNETQLVDISSRVQILESGDLLI 557
                |::.....|:..|..|...|:|.|.:.|         ..|:.|  ..:||..:..:|||.|
Human   347 ----PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ--QPNSRCSVSPTGDLTI 405

  Fly   558 SNIRSVDAGLYICVRANEAGSVKGEAYLSVL-VRTQ-----IIQPPVDTTVLLGLTATLQCKVSS 616
            :||:..|||.|||.....|||:..:|.|.|. |.|.     |:|.|.:.|:.:..||.|:||.:.
Human   406 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATG 470

  Fly   617 DPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLS 681
            || :|. |.|.:||  .|......|..:|..|.|:|:.:|.||.|:|.||.||..|..:.:|.|.
Human   471 DP-LPV-ISWLKEG--FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLD 531

  Fly   682 VIE-------------LPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQ--RREVSE 731
            |.|             ||.|||..:|   .:..:.|:.:||.||..|..|.|.:||:  .:.||.
Human   532 VTESGATISKNYDLSDLPGPPSKPQV---TDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSN 593

  Fly   732 LGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAP 796
                     :|.|..::|..  ....:..|:..|:|.|.|.|:|..|...||..|:.|.....:|
Human   594 ---------SWQTVANHVKT--TLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 647

  Fly   797 SGPPVGFVGSARSMSEIITQWQPPL-----------EEHRNGQ-ILGYILRYRLFGYNNVPWSYQ 849
            ....|......:.:.:::.:...|:           ...|..| |.||.:.||.........|:|
Human   648 PAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQ 712

  Fly   850 NITNE--AQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAI-- 910
            |:..:  .:|:.::..|.....|.:::..|.|...|:.:|...::|.|..|.|||.:|.|..:  
Human   713 NLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGS 777

  Fly   911 -NSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWR-DIERRMKTVPPSLIDPLAEQTAIL 973
             |||:....|.||.|...|||.|.|||  |   .:..|.| .|.   |||..::      ::.|:
Human   778 YNSTSISVSWDPPPPDHQNGIIQEYKI--W---CLGNETRFHIN---KTVDAAI------RSVII 828

  Fly   974 GGLEKFTEYNISVLCFTDPGDGVASSQ-----------VAVMTMDDVPDEVTGLHFDDVSDR--- 1024
            |||....:|.:.|...|..|.||.|..           |.....:.:.:::|     ||..:   
Human   829 GGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQIT-----DVVKQPAF 888

  Fly  1025 ---------------SVKVLWAPPRASNGILTGYTVRYQVKD--------RPDTLK----SFNLT 1062
                           |:.:.|.  |.....|:.|.|.:|..|        ||..|.    |:...
Human   889 IAGIGGACWVILMGFSIWLYWR--RKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWL 951

  Fly  1063 ADD---TELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAP-----TALALSNI 1119
            ||.   |.|.||...:..:         .:|:         .|...|||..|     ||..||:.
Human   952 ADSWPATSLPVNNSNSGPN---------EIGN---------FGRGDVLPPVPGQGDKTATMLSDG 998

  Fly  1120 EAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLSA 1184
            ..:|.: .||         ||                                   |.|.     
Human   999 AIYSSI-DFT---------TK-----------------------------------TSYN----- 1013

  Fly  1185 SNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPR------GY 1243
                .||:.::||             |: .|.:.:.:..:....:.|...:|..:.:      |:
Human  1014 ----SSSQITQAT-------------PY-ATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGF 1060

  Fly  1244 NISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERT 1308
            ..|.....|....:.|:|                   ::.|.|         |.|..        
Human  1061 GYSLPDQNKGNNALLYIP-------------------DYRLAE---------GLSNR-------- 1089

  Fly  1309 REAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATF 1373
               :|.....|....::.:::           .|:|.:.|.|......::......|.  |.:|:
Human  1090 ---MPHNQSQDFSTTSSHNSS-----------ERSGSLSGGKGGKKKKNKNSSKPQKN--NGSTW 1138

  Fly  1374 TTTL-----------TELKKYVVYHVQVLAYTRLGNGALS---TPPIRVQTF----------ED- 1413
            ....           |||:.|.|...:        ||..|   .||:.|||:          || 
Human  1139 ANVPLPPPPVQPLPGTELEHYAVEQQE--------NGYDSDSWCPPLPVQTYLHQGLEDELEEDD 1195

  Fly  1414 ----TPGVPSNVSFPDVS---------------------------LT------MARIIWDV---- 1437
                ||.|....|.|.:|                           ||      :|:..|.:    
Human  1196 DRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNN 1260

  Fly  1438 -----PVDPNGKILAYQVTYTLNGSAMLNYSREFPPSD-----------RTFRATELLPGK---Y 1483
                 ||.|.|.:         :|:.:.:...:....|           |..||.:..||.   .
Human  1261 QPPQPPVPPLGYV---------SGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDN 1316

  Fly  1484 YSFSCTAQTRLGW----------------------------GKIATALV---------------- 1504
            ...|.|.....||                            |..|.|||                
Human  1317 LDSSVTGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIFASGSFAQALVAAADKAGFRLDGTSLT 1381

  Fly  1505 -----YTTNNRERPQAP----SVPQISRSQIQAHQITFSWTPGRDGFAPLRYYTVEMRENEGRWQ 1560
                 :|::.|.||.:|    |....:.||.|..:.|.....||....|...:     ..||...
Human  1382 RTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPH-----RREGMTD 1441

  Fly  1561 PLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPS 1597
            .||...||.    ...|||            ..:|||
Human  1442 DLPPPPDPP----PGQGLR------------QQIGPS 1462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 33/87 (38%)
Ig 280..344 CDD:409353 10/67 (15%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 3/8 (38%)
Ig 360..451 CDD:472250 31/91 (34%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 1/3 (33%)
Ig strand E 416..420 CDD:409353 2/3 (67%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 29/93 (31%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 1/12 (8%)
Ig strand E 554..557 CDD:409353 2/2 (100%)
Ig strand F 567..572 CDD:409353 3/4 (75%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 34/94 (36%)
Ig strand B 608..612 CDD:409353 2/3 (67%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 31/104 (30%)
FN3 798..893 CDD:238020 19/108 (18%)
FN3 901..1005 CDD:238020 37/118 (31%)
FN3 <960..>1261 CDD:442628 62/355 (17%)
fn3 1317..1402 CDD:394996 15/95 (16%)
FN3 1415..1507 CDD:238020 29/196 (15%)
FN3 1513..1608 CDD:238020 22/89 (25%)
FN3 1583..>2011 CDD:442628 3/15 (20%)
ROBO2XP_011532283.1 IgC_1_Robo 54..152 CDD:409490 37/102 (36%)
Ig strand A 54..58 CDD:409490 2/3 (67%)
Ig strand A' 61..66 CDD:409490 2/6 (33%)
Ig strand B 70..78 CDD:409490 2/7 (29%)
Ig strand C 84..89 CDD:409490 2/4 (50%)
Ig strand C' 92..94 CDD:409490 0/1 (0%)
Ig strand D 105..108 CDD:409490 0/2 (0%)
Ig strand E 111..117 CDD:409490 3/8 (38%)
Ig strand F 129..137 CDD:409490 5/7 (71%)
Ig strand G 140..152 CDD:409490 2/11 (18%)
Ig 159..244 CDD:472250 29/197 (15%)
Ig strand B 173..177 CDD:409353 2/3 (67%)
Ig strand C 187..191 CDD:409353 0/3 (0%)
Ig strand E 209..213 CDD:409353 0/29 (0%)
Ig strand F 223..228 CDD:409353 3/4 (75%)
Ig strand G 237..240 CDD:409353 1/2 (50%)
Ig 251..333 CDD:472250 29/87 (33%)
Ig strand B 265..269 CDD:409353 1/3 (33%)
Ig strand C 278..282 CDD:409353 1/3 (33%)
Ig strand E 299..303 CDD:409353 2/3 (67%)
Ig strand F 313..318 CDD:409353 1/4 (25%)
Ig strand G 326..329 CDD:409353 1/2 (50%)
IgI_4_Robo 342..439 CDD:409391 32/133 (24%)
Ig strand A 342..346 CDD:409391 0/4 (0%)
Ig strand A' 348..352 CDD:409391 0/3 (0%)
Ig strand B 358..366 CDD:409391 2/7 (29%)
Ig strand C 369..376 CDD:409391 2/6 (33%)
Ig strand C' 378..381 CDD:409391 0/2 (0%)
Ig strand D 394..399 CDD:409391 1/4 (25%)
Ig strand E 401..408 CDD:409391 4/6 (67%)
Ig strand F 414..423 CDD:409391 4/8 (50%)
Ig strand G 425..436 CDD:409391 4/10 (40%)
IgI_5_Robo 446..532 CDD:409544 34/89 (38%)
Ig strand A 446..449 CDD:409544 1/2 (50%)
Ig strand A' 453..456 CDD:409544 0/2 (0%)
Ig strand B 462..469 CDD:409544 4/6 (67%)
Ig strand C 475..480 CDD:409544 2/5 (40%)
Ig strand C' 482..484 CDD:409544 1/3 (33%)
Ig strand D 491..495 CDD:409544 1/3 (33%)
Ig strand E 498..503 CDD:409544 2/4 (50%)
FN3 <510..882 CDD:442628 106/404 (26%)
Ig strand F 511..519 CDD:409544 4/7 (57%)
Ig strand G 522..532 CDD:409544 3/9 (33%)
FN3 549..642 CDD:238020 32/106 (30%)

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