DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and ROBO1

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_011532278.1 Gene:ROBO1 / 6091 HGNCID:10249 Length:1654 Species:Homo sapiens


Alignment Length:1843 Identity:372/1843 - (20%)
Similarity:602/1843 - (32%) Gaps:580/1843 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 DANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDG------- 111
            |.:|....|.::|:.. .||...|||.  .|||:|....|.|.|.|.|.||..|.|.|       
Human    51 DNSLGYTGSRLRQEDF-PPRIVEHPSD--LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDK 112

  Fly   112 ---------VPVGDFSSSQFYRF-HSTR-REDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENT 165
                     :|.|   |..|.|. |..: |.|.|.|.|:|||..|...|..:.:.||.:......
Human   113 DDPRSHRMLLPSG---SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ 174

  Fly   166 TEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADENDRKGYR 230
            ....:.|..|.||:.:..|....|.|::.|:.:..||:                  |:::|...|
Human   175 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD------------------DKDERITIR 221

  Fly   231 -AKAINTQLGKEESSAFVHL--NVSGDPYIEVAP-EIIVRPQDVKVKVGTGVVELQCIANARPLH 291
             .|.:.|...|.::..:|.:  |:.|:...|||. .::.||..||                ||  
Human   222 GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK----------------RP-- 268

  Fly   292 ELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQI 356
                    ..|||       |::|               |.|:.|:.|                 
Human   269 --------SNLAV-------TVDD---------------SAEFKCEAR----------------- 286

  Fly   357 LEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIK 421
                                         |:|.|.|:|.::    |..:...||.:..|:||.|:
Human   287 -----------------------------GDPVPTVRWRKD----DGELPKSRYEIRDDHTLKIR 318

  Fly   422 KLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESG 486
            |:...|...:.|:|.|..|:..||..|.|:                         :|||      
Human   319 KVTAGDMGSYTCVAENMVGKAEASATLTVQ-------------------------VGSE------ 352

  Fly   487 SSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLV-------DIS 544
                        .|...:.|::.....|:..|..|.|.|:|.|.|.|....:|.:       ..|
Human   353 ------------PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 405

  Fly   545 SRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQII---------QPPVDT 600
            ||..:.::|||.|:|::..|.|.|||...|.|||:..:|||.|   |.:|         |.||:.
Human   406 SRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV---TDVIADRPPPVIRQGPVNQ 467

  Fly   601 TVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYAC 665
            ||.:..|..|.|..:..| || .|.|.::|...:  :...||....:|.|:|:..:..|.|.|.|
Human   468 TVAVDGTFVLSCVATGSP-VP-TILWRKDGVLVS--TQDSRIKQLENGVLQIRYAKLGDTGRYTC 528

  Fly   666 VVTSPGGNETRAARLSVIELPFP------------PSNVKVERLPEPQQRSINVSWTPGFDGNSP 718
            :.::|.|..|.:|.:.|.|...|            ||......:.:..:.::.:||.|..:..:.
Human   529 IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGAT 593

  Fly   719 ISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPS 783
            .:.:||:....:...       :|.|...||..:..  .::.||...:|.|.|.|.|..|...||
Human   594 PTSYIIEAFSHASGS-------SWQTVAENVKTETS--AIKGLKPNAIYLFLVRAANAYGISDPS 649

  Fly   784 EPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPP-------LEEH-----RNGQILGYILRY 836
            :.|:.|:.....|:...|......|.:...:.....|       :|.|     ::..|.||.:.|
Human   650 QISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILY 714

  Fly   837 RLFGYNN--VPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPE 899
            |..|.|:  ..|....:...|:.:.:|.:|....:|.::...:.|...|..:|....||.|..|.
Human   715 RPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 779

  Fly   900 APPTNVKVEAI--NSTAARCRWTPPNPQQINGINQGYKIQAW---------QRRLIDGEWRDIER 953
            |||..|.|...  |.||....|.||.....||:.|.||:  |         ..:.:||.      
Human   780 APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYHINKTVDGS------ 836

  Fly   954 RMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDD-----VPDEV 1013
            ....|.|.|:..:              .|::.|...|..|.|| .|:...:.:|.     .|::.
Human   837 TFSVVIPFLVPGI--------------RYSVEVAASTGAGSGV-KSEPQFIQLDAHGNPVSPEDQ 886

  Fly  1014 TGL--HFDDVSDRSVKV-----------------LWAPPRASNGILTGY-------------TVR 1046
            ..|  ...||..:...:                 |:...:..||:.:.|             ||.
Human   887 VSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVT 951

  Fly  1047 YQ---------------------------------------------------------VKDRP- 1053
            ||                                                         ...|| 
Human   952 YQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 1016

  Fly  1054 DTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSG-------VEP---VLP 1108
            |.:.::|...|:.:..:...::|.:...::      .:.|.:..|..|.       |.|   ..|
Human  1017 DCIANYNNQLDNKQTNLMLPESTVYGDVDL------SNKINEMKTFNSPNLKDGRFVNPSGQPTP 1075

  Fly  1109 HAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNM--TWFTICE---INDPDAETLT 1168
            :|.|.|..||:..     ....| .|:|....||..||..:.:  ..:.|.|   :|.......|
Human  1076 YATTQLIQSNLSN-----NMNNG-SGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDT 1134

  Fly  1169 VTGLVPFTQ---------YRLRLSASNVVGS----------SKPSEATKDF-QTIQARPKHPP-- 1211
            |...:|:.|         |......|:..||          ..|.:...:: ..:...|.|||  
Human  1135 VPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPH 1199

  Fly  1212 -----FNVTVRAMSAQQLRVRWIP----LQQTEW--YGNPRGYNISYKQLVKTPGTIKYVPRSV- 1264
                 :|::|.....|::.....|    |||.|.  ..:.||.....:....:|..:.|..:|. 
Human  1200 SNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTA 1264

  Fly  1265 ------------VIED------HTANS--------------------HVLDSLEEWTLYEVKMNA 1291
                        :::|      |..:.                    |....:....:.::..:|
Human  1265 TLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDA 1329

  Fly  1292 CNDVGCSKESDTAVERTR-------EAVPSYGPLDVQANATSSTTVVVQWGEVPRQH-----RNG 1344
            ..:.....:.:.|..:||       |..|:....|::::.|.|  ::..||....:.     |:.
Human  1330 PEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGS--MINGWGSASEEDNISSGRSS 1392

  Fly  1345 QIDGYKVFYAAADRGQQV------------------------LHKT-IPNNATFTTTLTELKKYV 1384
            .......|:..||..|.|                        .|.: .|...:..:|.:.:...|
Human  1393 VSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAV 1457

  Fly  1385 VY-------------HVQVLAYT-RLGNGALSTPPIRVQTFED----------TPGVPS------ 1419
            :.             |::...|| .|....:..|.|:..|.:.          .|.:||      
Human  1458 MQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTD 1522

  Fly  1420 ------NVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSREFPPSDRTFRATEL 1478
                  ..|:....:...|.:.|:..:|.....|.:......|.......|:.||:.......::
Human  1523 RSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDI 1587

  Fly  1479 LPGKYYSF----------SCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITF 1533
            ||....:|          |.::.:..|.|           :|:|.||    .:.|..|...|:..
Human  1588 LPYCRPTFPTSNNPRDPSSSSSMSSRGSG-----------SRQREQA----NVGRRNIAEMQVLG 1637

  Fly  1534 SWTPGRDGFAPLRYYTVEMRENE 1556
            .:..|.|.       ..|:.|.|
Human  1638 GYERGEDN-------NEELEETE 1653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 31/87 (36%)
Ig 280..344 CDD:409353 11/63 (17%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 21/90 (23%)
Ig strand B 378..382 CDD:409353 0/3 (0%)
Ig strand C 391..395 CDD:409353 1/3 (33%)
Ig strand E 416..420 CDD:409353 2/3 (67%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 31/91 (34%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 1/3 (33%)
Ig strand E 554..557 CDD:409353 2/2 (100%)
Ig strand F 567..572 CDD:409353 3/4 (75%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 28/98 (29%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 23/114 (20%)
FN3 798..893 CDD:238020 20/108 (19%)
FN3 901..1005 CDD:238020 28/114 (25%)
FN3 <960..>1261 CDD:442628 74/443 (17%)
fn3 1317..1402 CDD:394996 19/128 (15%)
FN3 1415..1507 CDD:238020 18/113 (16%)
FN3 1513..1608 CDD:238020 10/44 (23%)
FN3 1583..>2011 CDD:442628
ROBO1XP_011532278.1 IgC_1_Robo 68..166 CDD:409490 35/102 (34%)
Ig strand A 68..72 CDD:409490 2/3 (67%)
Ig strand A' 75..80 CDD:409490 2/6 (33%)
Ig strand B 84..92 CDD:409490 2/7 (29%)
Ig strand C 98..103 CDD:409490 2/4 (50%)
Ig strand C' 106..108 CDD:409490 0/1 (0%)
Ig strand D 119..122 CDD:409490 0/2 (0%)
Ig strand E 125..131 CDD:409490 3/8 (38%)
Ig strand F 143..151 CDD:409490 4/7 (57%)
Ig strand G 154..166 CDD:409490 2/11 (18%)
IgI_2_Robo 173..258 CDD:409389 22/102 (22%)
Ig strand A 173..176 CDD:409389 0/2 (0%)
Ig strand A' 178..182 CDD:409389 0/3 (0%)
Ig strand B 186..193 CDD:409389 2/6 (33%)
Ig strand C 201..206 CDD:409389 1/4 (25%)
Ig strand C' 208..211 CDD:409389 0/2 (0%)
Ig strand D 217..221 CDD:409389 1/3 (33%)
Ig strand E 223..229 CDD:409389 1/5 (20%)
Ig strand F 236..244 CDD:409389 1/7 (14%)
Ig strand G 247..258 CDD:409389 4/10 (40%)
IgI_3_Robo 265..347 CDD:409390 34/179 (19%)
Ig strand A 265..268 CDD:409390 2/18 (11%)
Ig strand A' 270..274 CDD:409390 3/10 (30%)
Ig strand B 277..286 CDD:409390 4/23 (17%)
Ig strand C 292..297 CDD:409390 2/4 (50%)
Ig strand C' 300..303 CDD:409390 0/2 (0%)
Ig strand D 306..311 CDD:409390 2/4 (50%)
Ig strand E 312..319 CDD:409390 4/6 (67%)
Ig strand F 326..334 CDD:409390 2/7 (29%)
Ig strand G 337..347 CDD:409390 4/9 (44%)
IgI_4_Robo 355..452 CDD:409391 33/99 (33%)
Ig strand A 355..359 CDD:409391 0/3 (0%)
Ig strand A' 361..365 CDD:409391 0/3 (0%)
Ig strand B 371..379 CDD:409391 3/7 (43%)
Ig strand C 382..389 CDD:409391 3/6 (50%)
Ig strand C' 391..394 CDD:409391 0/2 (0%)
Ig strand D 407..412 CDD:409391 1/4 (25%)
Ig strand E 414..421 CDD:409391 4/6 (67%)
Ig strand F 427..436 CDD:409391 4/8 (50%)
FN3 428..882 CDD:442628 121/492 (25%)
Ig strand G 438..449 CDD:409391 6/13 (46%)
IgI_5_Robo 459..545 CDD:409544 27/89 (30%)
Ig strand A 459..462 CDD:409544 0/2 (0%)
Ig strand A' 466..469 CDD:409544 0/2 (0%)
Ig strand B 475..482 CDD:409544 2/6 (33%)
Ig strand C 488..493 CDD:409544 2/4 (50%)
Ig strand C' 495..497 CDD:409544 1/1 (100%)
Ig strand D 504..508 CDD:409544 2/3 (67%)
Ig strand E 511..516 CDD:409544 2/4 (50%)
Ig strand F 524..532 CDD:409544 3/7 (43%)
Ig strand G 535..545 CDD:409544 3/9 (33%)
FN3 564..650 CDD:238020 20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

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