DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and DSCAML1

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens


Alignment Length:1926 Identity:423/1926 - (21%)
Similarity:669/1926 - (34%) Gaps:583/1926 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 GSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYR------FHSTRREDAGSYQCIARNDAGS 146
            |.|..|.|.|.|||.|..||||||.|:.  :.|::.:      ....|.||:|:|.|...|..||
Human   252 GHTVELPCTASGYPIPAIRWLKDGRPLP--ADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGS 314

  Fly   147 IFSEKSDVVVAYMGIFENTTEGRL------TVI-----SGHP----------------------- 177
              :|.:.:::....:....|..:|      |||     :|.|                       
Human   315 --AEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRG 377

  Fly   178 ------------------------------------AIFDMPP---------------------- 184
                                                |:.|..|                      
Human   378 LSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCA 442

  Fly   185 IESIPVPSVMWQSEDGPLNYDIKY-----------AFTHANQLIILSADENDRKGYRAKAINTQL 238
            .:..|.|:|.|..:|.|:..|..:           ..:|.|   :......|...||..|.|. :
Human   443 AKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN---VTGPQIRDGGVYRCTARNL-V 503

  Fly   239 GKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANAR----PLHELETLWLK 299
            |..|..|  .:||.|.|.|.....|            |.|.....:.|.|    |.:.::  |.|
Human   504 GSAEYQA--RINVRGPPSIRAMRNI------------TAVAGRDTLINCRVIGYPYYSIK--WYK 552

  Fly   300 DGLAVETAGVRHTLNDPWNRTLALLQANSS-HSGEYTCQVRLRSGGYP--AVSASARLQILEPPL 361
            |.|.:.. ..|..:.:  |.||.|...... ..|||.|.|.::    |  ::|.|..:.:..|||
Human   553 DALLLPD-NHRQVVFE--NGTLKLTDVQKGMDEGEYLCSVLIQ----PQLSISQSVHVAVKVPPL 610

  Fly   362 F----FTPMRAETFGEFGGQVQLTCDVVGEPTP-QVKWFRNAESV----DAHIESGRYTLNTDNT 417
            .    |.|      ...|..:.:.|.|.....| ::.|.::.:.:    ...|||..:.    ::
Human   611 IQPFEFPP------ASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM----SS 665

  Fly   418 LVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKG 482
            |.|..:.|.....:.|:|     .|:|:|               :::.|.|.||.          
Human   666 LQISSVSLKHNGNYTCIA-----SNAAAT---------------VSRERQLIVRV---------- 700

  Fly   483 SESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIY-----NETQL-- 540
                            .|...:.|.|...:.||...::|...|.|.|.:.|.:     |..|.  
Human   701 ----------------PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHP 749

  Fly   541 VDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGS-VKGEAYLSVLVRTQIIQPPVDTTVLL 604
            |.::.|:|||.:..|||.::...|.|.|:|..:|..|: :....:|:|.:...|...|..|..:.
Human   750 VPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 814

  Fly   605 GLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRI----------GVQADGQLEIQAVRASD 659
            |....|.|....:.  |..|.|    :....:.:..|:          |.:....|:::.....|
Human   815 GHAKELNCTARGER--PIIIRW----EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 873

  Fly   660 VGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFII 724
            ...::|...:..|.:....:|:|.|.|.||   ::| :.|.:.||:|:.||..|||||.|:.|.|
Human   874 SVFFSCHAINSYGEDRGLIQLTVQEPPDPP---ELE-IREVKARSMNLRWTQRFDGNSIITGFDI 934

  Fly   725 QRREVSELGPVPDPLLNWITELS--NVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSN 787
            :.:..|:         :|..:.|  |:|.......:.:|..|:||..|:.:.|::|.   ||||.
Human   935 EYKNKSD---------SWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR---SEPSK 987

  Fly   788 VVELPQE--APSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWS--- 847
            .:.:..|  ||.|||:.......:...|...|:.|.:|.:||.|.||.:.||    .|.|.|   
Human   988 ELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYR----ENSPGSNGQ 1048

  Fly   848 YQNITNEAQRN---FLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEA 909
            |..:..:|..:   :.:..|..:..|.|.:.|:|..|.|..:......|.|.||..||.||:..:
Human  1049 YSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALS 1113

  Fly   910 INSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILG 974
            |.|..|...|:.|....:||:.:||::..|. ..:||||.:::....|          .:...|.
Human  1114 ITSDVAVISWSEPPRSTLNGVLKGYRVIFWS-LYVDGEWGEMQNITTT----------RERVELR 1167

  Fly   975 GLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGI 1039
            |:||||.|::.||.:|..||||.||.:.:.|.:|||....|:.....|..||.|.|.||...||:
Human  1168 GMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV 1232

  Fly  1040 LTGYTV-------------RYQVKDR--------------------------------------- 1052
            :..||:             .|:....                                       
Human  1233 IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPA 1297

  Fly  1053 ---PDTLKSFNLTA-----DDTELTVNQLQATTHYWFEIVAWTR--VGSGIPK------------ 1095
               |..:.||..|.     .|..|..|.:....    ..|.||:  ..|.||.            
Human  1298 GKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPA----PAVKWTKDSEDSAIPVSMDGHRLIHTNG 1358

  Fly  1096 -----------------TATIQSGVEPVL--------PHAPTALALSNIEAFSVVLQFTPGFDGN 1135
                             |||...|.:.::        |..| .|.:|...|.|:.|.:.||.:|.
Human  1359 TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQP-RLTVSKTSASSITLTWIPGDNGG 1422

  Fly  1136 SSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDF 1200
            |||..:.::.....:..|..:  .......:..:..|...|.|:::|:|.|.|||.:.||     
Human  1423 SSIRGFVLQYSVDNSEEWKDV--FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISE----- 1480

  Fly  1201 QTIQARP--KHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRS 1263
             .|:|:.  :.|.|:      ..|.|   :..:..|....|.:|:|.....:  |...::|.|:.
Human  1481 -IIEAKTHGREPSFS------KDQHL---FTHINSTHARLNLQGWNNGGCPI--TAIVLEYRPKG 1533

  Fly  1264 V-VIEDHTANSH---VLDSLEEWTLYEVKMNACNDVGCSKES----------------------- 1301
            . ..:...|||.   .|..|.|.|.||::|.|||..||..|:                       
Human  1534 TWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEG 1598

  Fly  1302 -------------------------------DTAVERTREAVPSYGPLDVQANATSSTTVVVQWG 1335
                                           :..::|.|:| .|...:.:..|..|..|.|....
Human  1599 DDVKKLFTIGCPVILATLGVALLFIVRKKRKEKRLKRLRDA-KSLAEMLISKNNRSFDTPVKGPP 1662

  Fly  1336 EVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYV----------VYHVQV 1390
            :.||.|    ||..:|.....|:  :.:.:...:.||...|..|..:.|          ::|..:
Human  1663 QGPRLH----IDIPRVQLLIEDK--EGIKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTL 1721

  Fly  1391 LAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDV--------------------SLTMARII- 1434
            :.         ||.|: :...:..||. :.||..:|                    :.|.||.: 
Human  1722 IQ---------STGPL-IDMSDIRPGT-NPVSRKNVKSAHSTRNRYSSQWTLTKCQASTPARTLT 1775

  Fly  1435 --WDVPVDPNGKILAYQVTYTLNGSAMLNYSREFPPSDRTFRATELLPGKYYSFS-----CTAQT 1492
              |......:|      ||.|.:.|...:.|::......:..:||.....|...:     ...:.
Human  1776 SDWRTVGSQHG------VTVTESDSYSASLSQDTDKGRNSMVSTESASSTYEELARAYEHAKLEE 1834

  Fly  1493 RLGWGKIATALVY---------TTNNRERPQA------PSVPQISRSQIQAHQITFSWTP----- 1537
            :|...|......:         ||...|...:      ||.|.|.|         |:.:|     
Human  1835 QLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTPSEPGICR---------FTASPPKPQD 1890

  Fly  1538 ---GRDGFAPLRYYTVE---------------MRENEGRWQPLPERVDPSLSSFTAVGLRPYMTY 1584
               |::...|:.:...:               .|:.:|| :|.|. |.|..:|...:. |.|.|.
Human  1891 ADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGR-EPCPV-VPPREASIRNLA-RTYHTQ 1952

  Fly  1585 QFRI---QATNDLG------PSAFSRESVIVRTL--PAAPA 1614
            ...:   .|:..||      |:|.|..::..|||  ||.||
Human  1953 ARHLTLDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPPA 1993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 23/59 (39%)
Ig 280..344 CDD:409353 17/68 (25%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 2/3 (67%)
Ig strand F 333..338 CDD:409353 3/4 (75%)
Ig 360..451 CDD:472250 20/99 (20%)
Ig strand B 378..382 CDD:409353 0/3 (0%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 26/92 (28%)
Ig strand B 517..521 CDD:409353 0/3 (0%)
Ig strand C 530..534 CDD:409353 0/3 (0%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 16/99 (16%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 1/3 (33%)
Ig strand F 662..667 CDD:409353 1/4 (25%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 34/104 (33%)
FN3 798..893 CDD:238020 26/100 (26%)
FN3 901..1005 CDD:238020 35/103 (34%)
FN3 <960..>1261 CDD:442628 87/401 (22%)
fn3 1317..1402 CDD:394996 17/94 (18%)
FN3 1415..1507 CDD:238020 20/128 (16%)
FN3 1513..1608 CDD:238020 26/132 (20%)
FN3 1583..>2011 CDD:442628 14/43 (33%)
DSCAML1XP_011541219.1 Ig 27..122 CDD:472250
Ig strand B 43..47 CDD:409353
Ig strand C 56..60 CDD:409353
Ig strand E 80..84 CDD:409353
Ig strand F 100..105 CDD:409353
Ig strand G 113..117 CDD:409353
Ig 130..218 CDD:472250
Ig strand B 142..146 CDD:409353
Ig strand C 158..162 CDD:409353
Ig strand E 180..184 CDD:409353
Ig strand F 195..200 CDD:409353
Ig strand G 211..214 CDD:409353
I-set 245..323 CDD:400151 27/74 (36%)
Ig strand B 255..259 CDD:409353 1/3 (33%)
Ig strand C 268..272 CDD:409353 1/3 (33%)
Ig strand F 303..308 CDD:409353 2/4 (50%)
Ig strand G 317..320 CDD:409353 0/2 (0%)
Ig 326..415 CDD:472250 7/88 (8%)
Ig strand B 344..348 CDD:409353 2/3 (67%)
Ig strand C 357..361 CDD:409353 0/3 (0%)
Ig strand E 381..385 CDD:409353 0/3 (0%)
Ig strand F 395..400 CDD:409353 0/4 (0%)
Ig strand G 408..411 CDD:409353 0/2 (0%)
Ig 419..514 CDD:472250 18/100 (18%)
Ig strand B 437..441 CDD:409353 0/3 (0%)
Ig strand C 450..454 CDD:409353 1/3 (33%)
Ig strand E 480..484 CDD:409353 2/6 (33%)
Ig strand F 494..499 CDD:409353 2/4 (50%)
Ig strand G 507..510 CDD:409353 1/2 (50%)
Ig 517..605 CDD:472250 25/108 (23%)
Ig strand B 534..538 CDD:409353 0/3 (0%)
Ig strand C 547..551 CDD:409353 0/5 (0%)
Ig strand E 569..573 CDD:409353 2/3 (67%)
Ig strand F 584..589 CDD:409353 3/4 (75%)
Ig strand G 598..601 CDD:409353 1/2 (50%)
Ig 608..698 CDD:472250 23/119 (19%)
Ig strand B 625..629 CDD:409353 0/3 (0%)
Ig strand C 639..643 CDD:409353 0/3 (0%)
Ig strand E 664..668 CDD:409353 1/3 (33%)
Ig strand F 678..683 CDD:409353 1/4 (25%)
Ig strand G 691..694 CDD:409353 0/2 (0%)
Ig_DSCAM 701..797 CDD:409397 27/95 (28%)
putative Ig strand A 701..705 CDD:409397 1/3 (33%)
putative Ig strand A' 710..714 CDD:409397 1/3 (33%)
putative Ig strand B 716..726 CDD:409397 3/9 (33%)
putative Ig strand C 732..738 CDD:409397 1/5 (20%)
putative Ig strand C' 745..748 CDD:409397 1/2 (50%)
putative Ig strand D 757..760 CDD:409397 2/2 (100%)
putative Ig strand E 762..768 CDD:409397 3/5 (60%)
putative Ig strand F 775..783 CDD:409397 3/7 (43%)
putative Ig strand G 788..797 CDD:409397 1/8 (13%)
Ig_DSCAM 798..898 CDD:409398 17/105 (16%)
putative Ig strand A 798..801 CDD:409398 0/2 (0%)
putative Ig strand A' 809..813 CDD:409398 1/3 (33%)
putative Ig strand B 816..823 CDD:409398 1/6 (17%)
putative Ig strand C 831..837 CDD:409398 2/9 (22%)
putative Ig strand C' 847..850 CDD:409398 0/2 (0%)
putative Ig strand D 856..860 CDD:409398 1/3 (33%)
putative Ig strand E 862..868 CDD:409398 1/5 (20%)
putative Ig strand F 875..883 CDD:409398 1/7 (14%)
putative Ig strand G 886..896 CDD:409398 2/9 (22%)
FN3 <895..1208 CDD:442628 108/343 (31%)
fn3 <1223..1289 CDD:394996 8/65 (12%)
Ig_3 1303..1379 CDD:464046 14/79 (18%)
FN3 1396..1486 CDD:238020 27/98 (28%)
FN3 1500..1572 CDD:238020 21/73 (29%)
Blue background indicates that the domain is not in the aligned region.

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